The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection

Epigenetic modifications to histones dictate the differentiation of naïve CD4 + T cells into different subsets of effector T helper (T H ) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of T H 1, T H 2 and r...

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Veröffentlicht in:	Cellular & molecular immunology 2020-03, Vol.17 (3), p.247-260
Hauptverfasser:	Chen, Xiangyu, Cao, Guoshuai, Wu, Jialin, Wang, Xinxin, Pan, Zhiwei, Gao, Jianbao, Tian, Qin, Xu, Lifan, Li, Zhirong, Hao, Yaxing, Huang, Qizhao, Wang, Pengcheng, Xiao, Minglu, Xie, Luoyingzi, Tang, Shupei, Liu, Zhenyu, Hu, Li, Tang, Jianfang, He, Ran, Wang, Li, Zhou, Xinyuan, Wu, Yuzhang, Chen, Mengjie, Sun, Beicheng, Zhu, Bo, Huang, Jun, Ye, Lilin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/1566/2493 631/250/2499 631/250/254 Antibodies Bcl-6 protein Biomedical and Life Sciences Biomedicine CD4 antigen Cell differentiation Cell fate Chromatin Effector cells Histone methyltransferase Histones Immunology Infections Lymphocytes Lymphocytes T Medical Microbiology Microbiology Vaccine Viral infections
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