Radiation-Induced Xerostomia: Objective Evaluation of Salivary Gland Injury Using MR Sialography
Xerostomia (dry mouth) is one of the serious complications of head and neck irradiation and has a strong influence on a patient's activities of daily living. MR sialography with salivary secretion stimulation provides additional functional information (salivary secretion reserve) and may contri...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2009-01, Vol.30 (1), p.53-58 |
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| creator | Wada, A Uchida, N Yokokawa, M Yoshizako, T Kitagaki, H |
| description | Xerostomia (dry mouth) is one of the serious complications of head and neck irradiation and has a strong influence on a patient's activities of daily living. MR sialography with salivary secretion stimulation provides additional functional information (salivary secretion reserve) and may contribute to the evaluation of the severity of xerostomia and predict the risk of developing a radiation-induced xerostomia. This aim of the study was to analyze MR sialography as an objective tool to evaluate radiation-induced salivary injury.
MR sialography with salivary secretion stimulation was performed in 16 patients with head and neck malignancy before and after irradiation therapy. Multivariate (stepwise multiple regression) analysis was performed to analyze the nonstimulated and stimulated MR sialography findings and the clinical severity of xerostomia.
Multivariate analysis of the preirradiation study revealed no significant independent variables that could predict the clinical severity of xerostomia. In the postirradiation study, following regression with 2 independent variables (secretion response of the submandibular gland [rSG] and parotid gland visualization on stimulated MR sialography [sPG]) could explain 70% of the cases: xerostomia severity grade = 0.681 + 0.871 x rSG - 0.471 x sPG.
MR sialography is a useful method for visualization of salivary gland radiation injury and estimation of the severity of radiation-induced xerostomia. Insufficiency of secretion reserve at the irradiated submandibular gland has the strongest influence on xerostomia severity. Our investigation suggests that careful submandibular gland protection may lead to prevention and avoidance of radiation-induced xerostomia. |
| doi_str_mv | 10.3174/ajnr.A1322 |
| format | Article |
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MR sialography with salivary secretion stimulation was performed in 16 patients with head and neck malignancy before and after irradiation therapy. Multivariate (stepwise multiple regression) analysis was performed to analyze the nonstimulated and stimulated MR sialography findings and the clinical severity of xerostomia.
Multivariate analysis of the preirradiation study revealed no significant independent variables that could predict the clinical severity of xerostomia. In the postirradiation study, following regression with 2 independent variables (secretion response of the submandibular gland [rSG] and parotid gland visualization on stimulated MR sialography [sPG]) could explain 70% of the cases: xerostomia severity grade = 0.681 + 0.871 x rSG - 0.471 x sPG.
MR sialography is a useful method for visualization of salivary gland radiation injury and estimation of the severity of radiation-induced xerostomia. Insufficiency of secretion reserve at the irradiated submandibular gland has the strongest influence on xerostomia severity. Our investigation suggests that careful submandibular gland protection may lead to prevention and avoidance of radiation-induced xerostomia.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A1322</identifier><identifier>PMID: 18842755</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Biological and medical sciences ; Electrodiagnosis. Electric activity recording ; Female ; Head & Neck ; Head and Neck Neoplasms - complications ; Head and Neck Neoplasms - radiotherapy ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Radiation Injuries - etiology ; Radiation Injuries - pathology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiotherapy, Conformal - adverse effects ; Salivary Glands - injuries ; Salivary Glands - pathology ; Xerostomia - etiology ; Xerostomia - pathology</subject><ispartof>American journal of neuroradiology : AJNR, 2009-01, Vol.30 (1), p.53-58</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © American Society of Neuroradiology 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-ef91b3687c165eca39a14d4d929c72e07df8c949e127143e238010f4fa88204b3</citedby><cites>FETCH-LOGICAL-c501t-ef91b3687c165eca39a14d4d929c72e07df8c949e127143e238010f4fa88204b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051706/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051706/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21046530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18842755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wada, A</creatorcontrib><creatorcontrib>Uchida, N</creatorcontrib><creatorcontrib>Yokokawa, M</creatorcontrib><creatorcontrib>Yoshizako, T</creatorcontrib><creatorcontrib>Kitagaki, H</creatorcontrib><title>Radiation-Induced Xerostomia: Objective Evaluation of Salivary Gland Injury Using MR Sialography</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Xerostomia (dry mouth) is one of the serious complications of head and neck irradiation and has a strong influence on a patient's activities of daily living. MR sialography with salivary secretion stimulation provides additional functional information (salivary secretion reserve) and may contribute to the evaluation of the severity of xerostomia and predict the risk of developing a radiation-induced xerostomia. This aim of the study was to analyze MR sialography as an objective tool to evaluate radiation-induced salivary injury.
MR sialography with salivary secretion stimulation was performed in 16 patients with head and neck malignancy before and after irradiation therapy. Multivariate (stepwise multiple regression) analysis was performed to analyze the nonstimulated and stimulated MR sialography findings and the clinical severity of xerostomia.
Multivariate analysis of the preirradiation study revealed no significant independent variables that could predict the clinical severity of xerostomia. In the postirradiation study, following regression with 2 independent variables (secretion response of the submandibular gland [rSG] and parotid gland visualization on stimulated MR sialography [sPG]) could explain 70% of the cases: xerostomia severity grade = 0.681 + 0.871 x rSG - 0.471 x sPG.
MR sialography is a useful method for visualization of salivary gland radiation injury and estimation of the severity of radiation-induced xerostomia. Insufficiency of secretion reserve at the irradiated submandibular gland has the strongest influence on xerostomia severity. Our investigation suggests that careful submandibular gland protection may lead to prevention and avoidance of radiation-induced xerostomia.</description><subject>Biological and medical sciences</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Female</subject><subject>Head & Neck</subject><subject>Head and Neck Neoplasms - complications</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Radiation Injuries - etiology</subject><subject>Radiation Injuries - pathology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiotherapy, Conformal - adverse effects</subject><subject>Salivary Glands - injuries</subject><subject>Salivary Glands - pathology</subject><subject>Xerostomia - etiology</subject><subject>Xerostomia - pathology</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1rGzEQhkVpady0l_6AokN7KWyq0cdq1UMhhCQ1pASSBnJTx1qtLSNrjbS2yb_PJjZpexKDnnlm5iXkI7ATAVp-w2XKJ6cgOH9FJmBEXRll7l-TCQOjqhpYc0TelbJkjCmj-VtyBE0juVZqQv7cYBtwCH2qpqndON_Se5_7MvSrgN_p9Wzp3RC2np5vMW6eQdp39BZj2GJ-oJcRU0unabkZi7sS0pz-uqG3AWM_z7hePLwnbzqMxX84vMfk7uL899nP6ur6cnp2elU5xWCofGdgJupGO6iVdygMgmxla7hxmnum265xRhoPXIMUnouGAetkh03DmZyJY_Jj711vZivfOp-GjNGuc1iNe9oeg_3_J4WFnfdbq5kCzepR8HUvcOP5JfvupReYfcrZPuVsn3Me4U__TvuLHoIdgS8HAIvD2GVMLpQXjgOTtRJs5D7vuUWYL3Yhe1tWGOOoBbvb7QSzYJUQj0_qlLM</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Wada, A</creator><creator>Uchida, N</creator><creator>Yokokawa, M</creator><creator>Yoshizako, T</creator><creator>Kitagaki, H</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20090101</creationdate><title>Radiation-Induced Xerostomia: Objective Evaluation of Salivary Gland Injury Using MR Sialography</title><author>Wada, A ; Uchida, N ; Yokokawa, M ; Yoshizako, T ; Kitagaki, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-ef91b3687c165eca39a14d4d929c72e07df8c949e127143e238010f4fa88204b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Female</topic><topic>Head & Neck</topic><topic>Head and Neck Neoplasms - complications</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Radiation Injuries - etiology</topic><topic>Radiation Injuries - pathology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiotherapy, Conformal - adverse effects</topic><topic>Salivary Glands - injuries</topic><topic>Salivary Glands - pathology</topic><topic>Xerostomia - etiology</topic><topic>Xerostomia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wada, A</creatorcontrib><creatorcontrib>Uchida, N</creatorcontrib><creatorcontrib>Yokokawa, M</creatorcontrib><creatorcontrib>Yoshizako, T</creatorcontrib><creatorcontrib>Kitagaki, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wada, A</au><au>Uchida, N</au><au>Yokokawa, M</au><au>Yoshizako, T</au><au>Kitagaki, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation-Induced Xerostomia: Objective Evaluation of Salivary Gland Injury Using MR Sialography</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>30</volume><issue>1</issue><spage>53</spage><epage>58</epage><pages>53-58</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>Xerostomia (dry mouth) is one of the serious complications of head and neck irradiation and has a strong influence on a patient's activities of daily living. MR sialography with salivary secretion stimulation provides additional functional information (salivary secretion reserve) and may contribute to the evaluation of the severity of xerostomia and predict the risk of developing a radiation-induced xerostomia. This aim of the study was to analyze MR sialography as an objective tool to evaluate radiation-induced salivary injury.
MR sialography with salivary secretion stimulation was performed in 16 patients with head and neck malignancy before and after irradiation therapy. Multivariate (stepwise multiple regression) analysis was performed to analyze the nonstimulated and stimulated MR sialography findings and the clinical severity of xerostomia.
Multivariate analysis of the preirradiation study revealed no significant independent variables that could predict the clinical severity of xerostomia. In the postirradiation study, following regression with 2 independent variables (secretion response of the submandibular gland [rSG] and parotid gland visualization on stimulated MR sialography [sPG]) could explain 70% of the cases: xerostomia severity grade = 0.681 + 0.871 x rSG - 0.471 x sPG.
MR sialography is a useful method for visualization of salivary gland radiation injury and estimation of the severity of radiation-induced xerostomia. Insufficiency of secretion reserve at the irradiated submandibular gland has the strongest influence on xerostomia severity. Our investigation suggests that careful submandibular gland protection may lead to prevention and avoidance of radiation-induced xerostomia.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>18842755</pmid><doi>10.3174/ajnr.A1322</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Electrodiagnosis. Electric activity recording Female Head & Neck Head and Neck Neoplasms - complications Head and Neck Neoplasms - radiotherapy Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Nervous system Radiation Injuries - etiology Radiation Injuries - pathology Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiotherapy, Conformal - adverse effects Salivary Glands - injuries Salivary Glands - pathology Xerostomia - etiology Xerostomia - pathology |
| title | Radiation-Induced Xerostomia: Objective Evaluation of Salivary Gland Injury Using MR Sialography |
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