Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements
Differentiating tumor growth from posttreatment radiation effect (PTRE) remains a common problem in neuro-oncology practice. To our knowledge, useful threshold relative cerebral blood volume (rCBV) values that accurately distinguish the 2 entities do not exist. Our prospective study uses image-guide...
Gespeichert in:
| Veröffentlicht in: | American journal of neuroradiology 2009-03, Vol.30 (3), p.552-558 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 558 |
|---|---|
| container_issue | 3 |
| container_start_page | 552 |
| container_title | American journal of neuroradiology |
| container_volume | 30 |
| creator | Hu, L.S Baxter, L.C Smith, K.A Feuerstein, B.G Karis, J.P Eschbacher, J.M Coons, S.W Nakaji, P Yeh, R.F Debbins, J Heiserman, J.E |
| description | Differentiating tumor growth from posttreatment radiation effect (PTRE) remains a common problem in neuro-oncology practice. To our knowledge, useful threshold relative cerebral blood volume (rCBV) values that accurately distinguish the 2 entities do not exist. Our prospective study uses image-guided neuronavigation during surgical resection of MR imaging lesions to correlate directly specimen histopathology with localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging (DSC) measurements and to establish accurate rCBV threshold values, which differentiate PTRE from tumor recurrence.
Preoperative 3T gradient-echo DSC and contrast-enhanced stereotactic T1-weighted images were obtained in patients with high-grade glioma (HGG) previously treated with multimodality therapy. Intraoperative neuronavigation documented the stereotactic location of multiple tissue specimens taken randomly from the periphery of enhancing MR imaging lesions. Coregistration of DSC and stereotactic images enabled calculation of localized rCBV within the previously recorded specimen locations. All tissue specimens were histopathologically categorized as tumor or PTRE and were correlated with corresponding rCBV values. All rCBV values were T1-weighted leakage-corrected with preload contrast-bolus administration and T2/T2*-weighted leakage-corrected with baseline subtraction integration.
Forty tissue specimens were collected from 13 subjects. The PTRE group (n = 16) rCBV values ranged from 0.21 to 0.71, tumor (n = 24) values ranged from 0.55 to 4.64, and 8.3% of tumor rCBV values fell within the PTRE group range. A threshold value of 0.71 optimized differentiation of the histopathologic groups with a sensitivity of 91.7% and a specificity of 100%.
rCBV measurements obtained by using DSC and the protocol we have described can differentiate HGG recurrence from PTRE with a high degree of accuracy. |
| doi_str_mv | 10.3174/ajnr.A1377 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7051449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19056837</sourcerecordid><originalsourceid>FETCH-LOGICAL-c543t-f9e8cdf02bad64b83433532a1cda80d408b526457bf2eb3f6178f36663f028753</originalsourceid><addsrcrecordid>eNpVUk1v0zAYDgjEyuDCiRPyhQtShh3ncwek0ZVuUiemMga36E38uvXkxJXtrCq_HmetNjj58Hzq9RNF7xg94axIP8Ndb0_OGC-K59GEVTyPq6z6_SKaUFZlcc5oeRS9du6OUppVRfIqOmIVzfKSF5Nn75eowat7JFO02FjQ5Ks2RpBbo4cOyS3oAR3xhpwrKQOl9wo8kgu1WsdzCwLJXCvTAVliO9iAt0ikNR25Ns57i-C7oCFLEEGnTE9mwab1p8HPhpdMTRDpPdSg3yL25LKDFcbzQQkU5EY5N4yBzpsN-LXRZrUj0AuyMC1o9Sdwznc9dKolPwbX4sarRmnld_EvDC19wKem9xacj2f9GkJDQa7RysGNoVfLhzzVr8gVghssjoXdm-ilBO3w7eE9jn5-m91ML-LF9_nl9GwRt1nKfSwrLFshadKAyNOm5CnnGU-AtQJKKlJaNlmSp1nRyAQbLnNWlJLnec6Dpiwyfhx92ftuhqZD0eLYVNcbqzqwu9qAqv9HerWuV-a-LmjG0rQKBp_2Bq01zlmUj1pG63Ef9biP-mEfgfzh37Qn6mEQgfDxQAAXrittOJdyj7yEJXme0vSJtw4n3oavrF0HWgdbVm-3Wx6i6yxL-F-budln</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Hu, L.S ; Baxter, L.C ; Smith, K.A ; Feuerstein, B.G ; Karis, J.P ; Eschbacher, J.M ; Coons, S.W ; Nakaji, P ; Yeh, R.F ; Debbins, J ; Heiserman, J.E</creator><creatorcontrib>Hu, L.S ; Baxter, L.C ; Smith, K.A ; Feuerstein, B.G ; Karis, J.P ; Eschbacher, J.M ; Coons, S.W ; Nakaji, P ; Yeh, R.F ; Debbins, J ; Heiserman, J.E</creatorcontrib><description>Differentiating tumor growth from posttreatment radiation effect (PTRE) remains a common problem in neuro-oncology practice. To our knowledge, useful threshold relative cerebral blood volume (rCBV) values that accurately distinguish the 2 entities do not exist. Our prospective study uses image-guided neuronavigation during surgical resection of MR imaging lesions to correlate directly specimen histopathology with localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging (DSC) measurements and to establish accurate rCBV threshold values, which differentiate PTRE from tumor recurrence.
Preoperative 3T gradient-echo DSC and contrast-enhanced stereotactic T1-weighted images were obtained in patients with high-grade glioma (HGG) previously treated with multimodality therapy. Intraoperative neuronavigation documented the stereotactic location of multiple tissue specimens taken randomly from the periphery of enhancing MR imaging lesions. Coregistration of DSC and stereotactic images enabled calculation of localized rCBV within the previously recorded specimen locations. All tissue specimens were histopathologically categorized as tumor or PTRE and were correlated with corresponding rCBV values. All rCBV values were T1-weighted leakage-corrected with preload contrast-bolus administration and T2/T2*-weighted leakage-corrected with baseline subtraction integration.
Forty tissue specimens were collected from 13 subjects. The PTRE group (n = 16) rCBV values ranged from 0.21 to 0.71, tumor (n = 24) values ranged from 0.55 to 4.64, and 8.3% of tumor rCBV values fell within the PTRE group range. A threshold value of 0.71 optimized differentiation of the histopathologic groups with a sensitivity of 91.7% and a specificity of 100%.
rCBV measurements obtained by using DSC and the protocol we have described can differentiate HGG recurrence from PTRE with a high degree of accuracy.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A1377</identifier><identifier>PMID: 19056837</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Biological and medical sciences ; Biopsy ; Blood Volume ; Brain ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - surgery ; Cardiovascular system ; Cerebrovascular Circulation ; Combined Modality Therapy ; Craniotomy ; Diagnosis, Differential ; Glioma - pathology ; Glioma - radiotherapy ; Glioma - surgery ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - standards ; Medical sciences ; Neoplasm Recurrence, Local - pathology ; Nervous system ; Neuronavigation ; Prospective Studies ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiotherapy - adverse effects ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>American journal of neuroradiology, 2009-03, Vol.30 (3), p.552-558</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © American Society of Neuroradiology 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-f9e8cdf02bad64b83433532a1cda80d408b526457bf2eb3f6178f36663f028753</citedby><cites>FETCH-LOGICAL-c543t-f9e8cdf02bad64b83433532a1cda80d408b526457bf2eb3f6178f36663f028753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051449/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051449/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,309,310,314,723,776,780,785,786,881,23909,23910,25118,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21266404$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19056837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, L.S</creatorcontrib><creatorcontrib>Baxter, L.C</creatorcontrib><creatorcontrib>Smith, K.A</creatorcontrib><creatorcontrib>Feuerstein, B.G</creatorcontrib><creatorcontrib>Karis, J.P</creatorcontrib><creatorcontrib>Eschbacher, J.M</creatorcontrib><creatorcontrib>Coons, S.W</creatorcontrib><creatorcontrib>Nakaji, P</creatorcontrib><creatorcontrib>Yeh, R.F</creatorcontrib><creatorcontrib>Debbins, J</creatorcontrib><creatorcontrib>Heiserman, J.E</creatorcontrib><title>Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements</title><title>American journal of neuroradiology</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Differentiating tumor growth from posttreatment radiation effect (PTRE) remains a common problem in neuro-oncology practice. To our knowledge, useful threshold relative cerebral blood volume (rCBV) values that accurately distinguish the 2 entities do not exist. Our prospective study uses image-guided neuronavigation during surgical resection of MR imaging lesions to correlate directly specimen histopathology with localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging (DSC) measurements and to establish accurate rCBV threshold values, which differentiate PTRE from tumor recurrence.
Preoperative 3T gradient-echo DSC and contrast-enhanced stereotactic T1-weighted images were obtained in patients with high-grade glioma (HGG) previously treated with multimodality therapy. Intraoperative neuronavigation documented the stereotactic location of multiple tissue specimens taken randomly from the periphery of enhancing MR imaging lesions. Coregistration of DSC and stereotactic images enabled calculation of localized rCBV within the previously recorded specimen locations. All tissue specimens were histopathologically categorized as tumor or PTRE and were correlated with corresponding rCBV values. All rCBV values were T1-weighted leakage-corrected with preload contrast-bolus administration and T2/T2*-weighted leakage-corrected with baseline subtraction integration.
Forty tissue specimens were collected from 13 subjects. The PTRE group (n = 16) rCBV values ranged from 0.21 to 0.71, tumor (n = 24) values ranged from 0.55 to 4.64, and 8.3% of tumor rCBV values fell within the PTRE group range. A threshold value of 0.71 optimized differentiation of the histopathologic groups with a sensitivity of 91.7% and a specificity of 100%.
rCBV measurements obtained by using DSC and the protocol we have described can differentiate HGG recurrence from PTRE with a high degree of accuracy.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood Volume</subject><subject>Brain</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain Neoplasms - surgery</subject><subject>Cardiovascular system</subject><subject>Cerebrovascular Circulation</subject><subject>Combined Modality Therapy</subject><subject>Craniotomy</subject><subject>Diagnosis, Differential</subject><subject>Glioma - pathology</subject><subject>Glioma - radiotherapy</subject><subject>Glioma - surgery</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Nervous system</subject><subject>Neuronavigation</subject><subject>Prospective Studies</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiotherapy - adverse effects</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUk1v0zAYDgjEyuDCiRPyhQtShh3ncwek0ZVuUiemMga36E38uvXkxJXtrCq_HmetNjj58Hzq9RNF7xg94axIP8Ndb0_OGC-K59GEVTyPq6z6_SKaUFZlcc5oeRS9du6OUppVRfIqOmIVzfKSF5Nn75eowat7JFO02FjQ5Ks2RpBbo4cOyS3oAR3xhpwrKQOl9wo8kgu1WsdzCwLJXCvTAVliO9iAt0ikNR25Ns57i-C7oCFLEEGnTE9mwab1p8HPhpdMTRDpPdSg3yL25LKDFcbzQQkU5EY5N4yBzpsN-LXRZrUj0AuyMC1o9Sdwznc9dKolPwbX4sarRmnld_EvDC19wKem9xacj2f9GkJDQa7RysGNoVfLhzzVr8gVghssjoXdm-ilBO3w7eE9jn5-m91ML-LF9_nl9GwRt1nKfSwrLFshadKAyNOm5CnnGU-AtQJKKlJaNlmSp1nRyAQbLnNWlJLnec6Dpiwyfhx92ftuhqZD0eLYVNcbqzqwu9qAqv9HerWuV-a-LmjG0rQKBp_2Bq01zlmUj1pG63Ef9biP-mEfgfzh37Qn6mEQgfDxQAAXrittOJdyj7yEJXme0vSJtw4n3oavrF0HWgdbVm-3Wx6i6yxL-F-budln</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Hu, L.S</creator><creator>Baxter, L.C</creator><creator>Smith, K.A</creator><creator>Feuerstein, B.G</creator><creator>Karis, J.P</creator><creator>Eschbacher, J.M</creator><creator>Coons, S.W</creator><creator>Nakaji, P</creator><creator>Yeh, R.F</creator><creator>Debbins, J</creator><creator>Heiserman, J.E</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements</title><author>Hu, L.S ; Baxter, L.C ; Smith, K.A ; Feuerstein, B.G ; Karis, J.P ; Eschbacher, J.M ; Coons, S.W ; Nakaji, P ; Yeh, R.F ; Debbins, J ; Heiserman, J.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-f9e8cdf02bad64b83433532a1cda80d408b526457bf2eb3f6178f36663f028753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blood Volume</topic><topic>Brain</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain Neoplasms - surgery</topic><topic>Cardiovascular system</topic><topic>Cerebrovascular Circulation</topic><topic>Combined Modality Therapy</topic><topic>Craniotomy</topic><topic>Diagnosis, Differential</topic><topic>Glioma - pathology</topic><topic>Glioma - radiotherapy</topic><topic>Glioma - surgery</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - standards</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Nervous system</topic><topic>Neuronavigation</topic><topic>Prospective Studies</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiotherapy - adverse effects</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, L.S</creatorcontrib><creatorcontrib>Baxter, L.C</creatorcontrib><creatorcontrib>Smith, K.A</creatorcontrib><creatorcontrib>Feuerstein, B.G</creatorcontrib><creatorcontrib>Karis, J.P</creatorcontrib><creatorcontrib>Eschbacher, J.M</creatorcontrib><creatorcontrib>Coons, S.W</creatorcontrib><creatorcontrib>Nakaji, P</creatorcontrib><creatorcontrib>Yeh, R.F</creatorcontrib><creatorcontrib>Debbins, J</creatorcontrib><creatorcontrib>Heiserman, J.E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, L.S</au><au>Baxter, L.C</au><au>Smith, K.A</au><au>Feuerstein, B.G</au><au>Karis, J.P</au><au>Eschbacher, J.M</au><au>Coons, S.W</au><au>Nakaji, P</au><au>Yeh, R.F</au><au>Debbins, J</au><au>Heiserman, J.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements</atitle><jtitle>American journal of neuroradiology</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>30</volume><issue>3</issue><spage>552</spage><epage>558</epage><pages>552-558</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>Differentiating tumor growth from posttreatment radiation effect (PTRE) remains a common problem in neuro-oncology practice. To our knowledge, useful threshold relative cerebral blood volume (rCBV) values that accurately distinguish the 2 entities do not exist. Our prospective study uses image-guided neuronavigation during surgical resection of MR imaging lesions to correlate directly specimen histopathology with localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging (DSC) measurements and to establish accurate rCBV threshold values, which differentiate PTRE from tumor recurrence.
Preoperative 3T gradient-echo DSC and contrast-enhanced stereotactic T1-weighted images were obtained in patients with high-grade glioma (HGG) previously treated with multimodality therapy. Intraoperative neuronavigation documented the stereotactic location of multiple tissue specimens taken randomly from the periphery of enhancing MR imaging lesions. Coregistration of DSC and stereotactic images enabled calculation of localized rCBV within the previously recorded specimen locations. All tissue specimens were histopathologically categorized as tumor or PTRE and were correlated with corresponding rCBV values. All rCBV values were T1-weighted leakage-corrected with preload contrast-bolus administration and T2/T2*-weighted leakage-corrected with baseline subtraction integration.
Forty tissue specimens were collected from 13 subjects. The PTRE group (n = 16) rCBV values ranged from 0.21 to 0.71, tumor (n = 24) values ranged from 0.55 to 4.64, and 8.3% of tumor rCBV values fell within the PTRE group range. A threshold value of 0.71 optimized differentiation of the histopathologic groups with a sensitivity of 91.7% and a specificity of 100%.
rCBV measurements obtained by using DSC and the protocol we have described can differentiate HGG recurrence from PTRE with a high degree of accuracy.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>19056837</pmid><doi>10.3174/ajnr.A1377</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-6108 |
| ispartof | American journal of neuroradiology, 2009-03, Vol.30 (3), p.552-558 |
| issn | 0195-6108 1936-959X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7051449 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Biological and medical sciences Biopsy Blood Volume Brain Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Cardiovascular system Cerebrovascular Circulation Combined Modality Therapy Craniotomy Diagnosis, Differential Glioma - pathology Glioma - radiotherapy Glioma - surgery Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - standards Medical sciences Neoplasm Recurrence, Local - pathology Nervous system Neuronavigation Prospective Studies Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiotherapy - adverse effects Reproducibility of Results Sensitivity and Specificity |
| title | Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T23%3A24%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relative%20Cerebral%20Blood%20Volume%20Values%20to%20Differentiate%20High-Grade%20Glioma%20Recurrence%20from%20Posttreatment%20Radiation%20Effect:%20Direct%20Correlation%20between%20Image-Guided%20Tissue%20Histopathology%20and%20Localized%20Dynamic%20Susceptibility-Weighted%20Contrast-Enhanced%20Perfusion%20MR%20Imaging%20Measurements&rft.jtitle=American%20journal%20of%20neuroradiology&rft.au=Hu,%20L.S&rft.date=2009-03-01&rft.volume=30&rft.issue=3&rft.spage=552&rft.epage=558&rft.pages=552-558&rft.issn=0195-6108&rft.eissn=1936-959X&rft.coden=AAJNDL&rft_id=info:doi/10.3174/ajnr.A1377&rft_dat=%3Cpubmed_cross%3E19056837%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19056837&rfr_iscdi=true |