The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis

Abstract Transposable elements (TEs) comprise a large proportion of long non-coding RNAs (lncRNAs). Here, we employed CRISPR to delete a short interspersed nuclear element (SINE) in Malat1, a cancer-associated lncRNA, to investigate its significance in cellular physiology. We show that Malat1 with a...

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Veröffentlicht in:	Nucleic acids research 2020-03, Vol.48 (5), p.2621-2642
Hauptverfasser:	Nguyen, Tuan M, Kabotyanski, Elena B, Reineke, Lucas C, Shao, Jiaofang, Xiong, Feng, Lee, Joo-Hyung, Dubrulle, Julien, Johnson, Hannah, Stossi, Fabio, Tsoi, Phoebe S, Choi, Kyoung-Jae, Ellis, Alexander G, Zhao, Na, Cao, Jin, Adewunmi, Oluwatoyosi, Ferreon, Josephine C, Ferreon, Allan Chris M, Neilson, Joel R, Mancini, Michael A, Chen, Xi, Kim, Jongchan, Ma, Li, Li, Wenbo, Rosen, Jeffrey M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry & Molecular Biology Cell Line Cytoplasm - metabolism DNA Damage DNA-Binding Proteins - metabolism eIF-2 Kinase Endoplasmic Reticulum Stress Enzyme Activation Gene Dosage Heterogeneous-Nuclear Ribonucleoprotein K - metabolism Humans Life Sciences & Biomedicine Mitosis Models, Biological Protein Transport Proteostasis - genetics RNA and RNA-protein complexes RNA, Long Noncoding - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Science & Technology Sequence Deletion - genetics Short Interspersed Nucleotide Elements - genetics
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