In situ genetic engineering of tumors for long-lasting and systemic immunotherapy

Cancer immunotherapy has been the subject of extensive research, but highly effective and broadly applicable methods remain elusive. Moreover, a general approach to engender endogenous patientspecific cellular therapy, without the need for a priori knowledge of tumor antigen, ex vivo cellular manipu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-02, Vol.117 (8), p.4043-4052
Hauptverfasser:	Tzeng, Stephany Y., Patel, Kisha K., Wilson, David R., Meyer, Randall A., Rhodes, Kelly R., Green, Jordan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antigen (tumor-associated) Antigen-presenting cells Antigens Biodegradability Biodegradation Biological Sciences Biotechnology Cancer Cancer immunotherapy Cellular manufacture Colorectal carcinoma Cytokines Cytotoxicity Genetic engineering Immune checkpoint Immune response Immune response (cell-mediated) Immune system Immunostimulation Immunotherapy Interleukin 12 Melanoma Nanoparticles Nanotechnology Physical Sciences Tumors
Online-Zugang:	Volltext
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