Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations

Abstract Context Aldosterone-producing adrenocortical adenomas (APAs) are mainly composed of clear (lipid rich) and compact (eosinophilic) tumor cells. The detailed association between these histological features and somatic mutations (KCNJ5, ATP1A1, ATP2B3, and CACNA1D) in APAs is unknown. Objectiv...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-03, Vol.105 (3), p.e282-e289
Hauptverfasser:	Ono, Yoshikiyo, Yamazaki, Yuto, Omata, Kei, Else, Tobias, Tomlins, Scott A, Rhayem, Yara, Williams, Tracy Ann, Reincke, Martin, Carling, Tobias, Monticone, Silvia, Mulatero, Paolo, Beuschlein, Felix, Ito, Sadayoshi, Satoh, Fumitoshi, Rainey, William E, Sasano, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone Aldosterone synthase Cell differentiation Endocrine disorders Genotypes Immunoreactivity Leukocytes (eosinophilic) Mutation Neuroendocrine tumors Next-generation sequencing Online Only Tumor cells Tumors Zonation
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