IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease

Coeliac disease is a complex, polygenic inflammatory enteropathy caused by exposure to dietary gluten that occurs in a subset of genetically susceptible individuals who express either the HLA-DQ8 or HLA-DQ2 haplotypes 1 , 2 . The need to develop non-dietary treatments is now widely recognized 3 , bu...

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Veröffentlicht in:	Nature (London) 2020-02, Vol.578 (7796), p.600-604
Hauptverfasser:	Abadie, Valérie, Kim, Sangman M., Lejeune, Thomas, Palanski, Brad A., Ernest, Jordan D., Tastet, Olivier, Voisine, Jordan, Discepolo, Valentina, Marietta, Eric V., Hawash, Mohamed B. F., Ciszewski, Cezary, Bouziat, Romain, Panigrahi, Kaushik, Horwath, Irina, Zurenski, Matthew A., Lawrence, Ian, Dumaine, Anne, Yotova, Vania, Grenier, Jean-Christophe, Murray, Joseph A., Khosla, Chaitan, Barreiro, Luis B., Jabri, Bana
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 38/61 38/91 631/250/249/1313/1357 631/250/347 Animals Antigens Atrophy Autoimmune diseases CD4 antigen CD4-Positive T-Lymphocytes - immunology Celiac disease Celiac Disease - immunology Celiac Disease - pathology Cytokines Cytotoxicity Destruction Epithelial cells Epithelium Female Genetics Genotype & phenotype Gluten Glutens - immunology Health aspects Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology Humanities and Social Sciences Humans Hypotheses Immunoglobulins Inflammation Ingestion Innate immunity Interferon Interferon-gamma - immunology Interleukin 15 Interleukin-15 - genetics Interleukin-15 - immunology Interleukins Intestine Lamina propria Ligands Lymphocytes Lymphocytes T Lysis Male Mice Mice, Transgenic Microfilament Proteins - genetics Microfilament Proteins - metabolism Morphology multidisciplinary Pathogenesis Physiological aspects Rodents Science Science (multidisciplinary) Transgenic animals Transglutaminase 2
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