Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics

Hyperprogressive disease (HPD), an unexpected acceleration of tumor growth kinetics, is described in cancer patients treated with anti-PD-1/anti-PD-L1 agents. Here, our aim was to take into consideration the host and explore whether single nucleotide polymorphisms (SNPs) in key genes involved in imm...

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Veröffentlicht in:	Scientific reports 2020-02, Vol.10 (1), p.3565-3565, Article 3565
Hauptverfasser:	Refae, Sadal, Gal, Jocelyn, Brest, Patrick, Giacchero, Damien, Borchiellini, Delphine, Ebran, Nathalie, Peyrade, Frederic, Guigay, Joël, Milano, Gérard, Saada-Bouzid, Esma
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 692/4028/67/68/2486 692/53/2423 Adult Age Aged Aged, 80 and over Antineoplastic Agents - administration & dosage B7-H1 Antigen - genetics B7-H1 Antigen - immunology Cancer Cell Proliferation Confidence intervals Disease Progression Female Genes Genomics Genotype & phenotype Growth kinetics Humanities and Social Sciences Humans Immune checkpoint Immune Checkpoint Inhibitors - administration & dosage Immune response Immunogenetics Immunology Immunotherapy Life Sciences Male Middle Aged multidisciplinary Multivariate analysis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - immunology Neoplasms - mortality Patients PD-1 protein PD-L1 protein Polymorphism, Single Nucleotide Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - immunology Science Science (multidisciplinary) Single-nucleotide polymorphism Toxicity Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - immunology
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