Mediterranean Journal of Rheumatology June 2018 Issue Highlights

Panagopoulos et al.1 reviewed the role of microRNAs (miRNAs) in the pathogenesis of osteoarthritis (OA) and their potential role as therapeutic targets in this disease. miRNAs are small, single-stranded non-coding RNAs that regulate gene expression at the post-transcriptional level. ABD shares features of autoimmune disease and autoinflammatory disease and the authors elaborate that an early event in B cells, such as IgH translocation, may make them sensitive to growth factors, such as interleukin(IL)-6 which is raised in ABD. O’Brien et al.9 in a research protocol will examine longitudinal relationships between sedentary behavior (defined as waking behavior characterized by ≤ 1.5 metabolic equivalents, METS) while in a sitting, reclining or lying position, or light intensity physical activity (1.6- Calcified chest lymph nodes in a patient with systemic sclerosis (SSc) is a rare finding in SSc.