Intestinal ex vivo organoid culture reveals altered programmed crypt stem cells in patients with celiac disease

The ex vivo generation of gastrointestinal organoids from crypt stem cells opens up the possibility of new research approaches investigating gastrointestinal diseases. We used this technology to study differences between healthy controls and patients with celiac disease (CD). We noticed distinct dis...

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Veröffentlicht in:	Scientific reports 2020-02, Vol.10 (1), p.3535-3535, Article 3535
Hauptverfasser:	Dieterich, Walburga, Neurath, Markus F., Zopf, Yurdagül
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/105 13/106 38 38/39 38/90 692/4020/1503 692/4020/2199 Adolescent Adult Aged Autoimmune diseases Celiac disease Celiac Disease - metabolism Celiac Disease - pathology Cell culture Duodenum - metabolism Duodenum - pathology Epigenesis, Genetic Epigenetics Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Gastrointestinal diseases Gene expression Humanities and Social Sciences Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Male Mesenchyme Middle Aged multidisciplinary Organ Culture Techniques Organoids Organoids - metabolism Organoids - pathology Phenotypes Science Science (multidisciplinary) Stem cells Stem Cells - metabolism Stem Cells - pathology Villus
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