Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women
Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population. Methods: We conducted a...
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| Veröffentlicht in: | Diabetes & metabolism journal 2020, 44(1), 177, pp.134-142 |
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| creator | Wang, Yeli Zhu, Jingwen Aroner, Sarah Overvad, Kim Cai, Tianxi Yang, Ming Tjonneland, Anne Handberg, Aase Jensen, Majken K. |
| description | Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.
Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).
Results: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.
Conclusion: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity. |
| doi_str_mv | 10.4093/dmj.2018.0273 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7043971</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_3730e007e8aa4975a4d3bbda0c138548</doaj_id><sourcerecordid>2313376133</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-c0a5de458bcd2243eac8e14fde639b832f17640e2aa035924be1dd85b25e656f3</originalsourceid><addsrcrecordid>eNqNkktv1DAUhSMEolXpki3KEoQy-JXYYYE0yvAYqTwERSytG_um42lilzgB9d_jmSkjusML-8r-zvGVj7PsKSULQWr-yg7bBSNULQiT_EF2yhjnRUWUfHisZX2Snce4JWkIRaSsH2cnnEpCK1WeZp--9BAHyJsVr3LwNl974yz6KV85aHHC-Dpf5g1ELJqwCeOUf5tme5s7n6_Au7jJP6LfC3-EAf2T7FEHfcTzu_Us-_7u7WXzobj4_H7dLC8KI5ScCkOgtChK1RrLmOAIRiEVncWK163irKOyEgQZAOFlzUSL1FpVtqzEqqw6fpa9OPj6sdPXxukAbr9eBX096uXXy7WuakKpUIldH1gbYKtvRjfAeLsX7DfCeKVhnJzpUXPJCRIiUQGIWpYgLG9bC8RQrsq915uD183cDmhNeqgR-num90-826SefmlJBK8lTQbP7wzG8HPGOOnBRYN9Dx7DHDXjlHNZpSmhxQE1Y4hxxO54DSV6F79O8etd_HoXf-Kf_dvbkf4bdgLUAfiNbeiicegNHrH0P0oqpapoqihr3ASTC74Js5-S9OX_S_kfdl_I8A</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2313376133</pqid></control><display><type>article</type><title>Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women</title><source>KoreaMed Synapse</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>KoreaMed Open Access</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>PubMed Central</source><creator>Wang, Yeli ; Zhu, Jingwen ; Aroner, Sarah ; Overvad, Kim ; Cai, Tianxi ; Yang, Ming ; Tjonneland, Anne ; Handberg, Aase ; Jensen, Majken K.</creator><creatorcontrib>Wang, Yeli ; Zhu, Jingwen ; Aroner, Sarah ; Overvad, Kim ; Cai, Tianxi ; Yang, Ming ; Tjonneland, Anne ; Handberg, Aase ; Jensen, Majken K.</creatorcontrib><description>Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.
Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).
Results: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.
Conclusion: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.</description><identifier>ISSN: 2233-6079</identifier><identifier>EISSN: 2233-6087</identifier><identifier>DOI: 10.4093/dmj.2018.0273</identifier><identifier>PMID: 31701685</identifier><language>eng</language><publisher>SEOUL: Korean Diabetes Assoc</publisher><subject>adiposity ; biomarkers ; cd36 antigens ; diabetes mellitus, type 2 ; Endocrinology & Metabolism ; epidemiology ; Life Sciences & Biomedicine ; Original ; prospective studies ; Science & Technology ; 내과학</subject><ispartof>Diabetes and Metabolism Journal, 2020, 44(1), 177, pp.134-142</ispartof><rights>Copyright © 2020 Korean Diabetes Association.</rights><rights>Copyright © 2020 Korean Diabetes Association 2020 Korean Diabetes Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000517786100012</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c487t-c0a5de458bcd2243eac8e14fde639b832f17640e2aa035924be1dd85b25e656f3</citedby><cites>FETCH-LOGICAL-c487t-c0a5de458bcd2243eac8e14fde639b832f17640e2aa035924be1dd85b25e656f3</cites><orcidid>0000-0003-1367-9537 ; 0000-0003-3031-6199 ; 0000-0001-6429-7921 ; 0000-0003-4385-2097 ; 0000-0001-5719-203X ; 0000-0003-4729-7545</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043971/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043971/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31701685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002563130$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yeli</creatorcontrib><creatorcontrib>Zhu, Jingwen</creatorcontrib><creatorcontrib>Aroner, Sarah</creatorcontrib><creatorcontrib>Overvad, Kim</creatorcontrib><creatorcontrib>Cai, Tianxi</creatorcontrib><creatorcontrib>Yang, Ming</creatorcontrib><creatorcontrib>Tjonneland, Anne</creatorcontrib><creatorcontrib>Handberg, Aase</creatorcontrib><creatorcontrib>Jensen, Majken K.</creatorcontrib><title>Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women</title><title>Diabetes & metabolism journal</title><addtitle>DIABETES METAB J</addtitle><addtitle>Diabetes Metab J</addtitle><description>Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.
Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).
Results: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.
Conclusion: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.</description><subject>adiposity</subject><subject>biomarkers</subject><subject>cd36 antigens</subject><subject>diabetes mellitus, type 2</subject><subject>Endocrinology & Metabolism</subject><subject>epidemiology</subject><subject>Life Sciences & Biomedicine</subject><subject>Original</subject><subject>prospective studies</subject><subject>Science & Technology</subject><subject>내과학</subject><issn>2233-6079</issn><issn>2233-6087</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktv1DAUhSMEolXpki3KEoQy-JXYYYE0yvAYqTwERSytG_um42lilzgB9d_jmSkjusML-8r-zvGVj7PsKSULQWr-yg7bBSNULQiT_EF2yhjnRUWUfHisZX2Snce4JWkIRaSsH2cnnEpCK1WeZp--9BAHyJsVr3LwNl974yz6KV85aHHC-Dpf5g1ELJqwCeOUf5tme5s7n6_Au7jJP6LfC3-EAf2T7FEHfcTzu_Us-_7u7WXzobj4_H7dLC8KI5ScCkOgtChK1RrLmOAIRiEVncWK163irKOyEgQZAOFlzUSL1FpVtqzEqqw6fpa9OPj6sdPXxukAbr9eBX096uXXy7WuakKpUIldH1gbYKtvRjfAeLsX7DfCeKVhnJzpUXPJCRIiUQGIWpYgLG9bC8RQrsq915uD183cDmhNeqgR-num90-826SefmlJBK8lTQbP7wzG8HPGOOnBRYN9Dx7DHDXjlHNZpSmhxQE1Y4hxxO54DSV6F79O8etd_HoXf-Kf_dvbkf4bdgLUAfiNbeiicegNHrH0P0oqpapoqihr3ASTC74Js5-S9OX_S_kfdl_I8A</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Wang, Yeli</creator><creator>Zhu, Jingwen</creator><creator>Aroner, Sarah</creator><creator>Overvad, Kim</creator><creator>Cai, Tianxi</creator><creator>Yang, Ming</creator><creator>Tjonneland, Anne</creator><creator>Handberg, Aase</creator><creator>Jensen, Majken K.</creator><general>Korean Diabetes Assoc</general><general>Korean Diabetes Association</general><general>대한당뇨병학회</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0003-1367-9537</orcidid><orcidid>https://orcid.org/0000-0003-3031-6199</orcidid><orcidid>https://orcid.org/0000-0001-6429-7921</orcidid><orcidid>https://orcid.org/0000-0003-4385-2097</orcidid><orcidid>https://orcid.org/0000-0001-5719-203X</orcidid><orcidid>https://orcid.org/0000-0003-4729-7545</orcidid></search><sort><creationdate>20200201</creationdate><title>Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women</title><author>Wang, Yeli ; Zhu, Jingwen ; Aroner, Sarah ; Overvad, Kim ; Cai, Tianxi ; Yang, Ming ; Tjonneland, Anne ; Handberg, Aase ; Jensen, Majken K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-c0a5de458bcd2243eac8e14fde639b832f17640e2aa035924be1dd85b25e656f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>adiposity</topic><topic>biomarkers</topic><topic>cd36 antigens</topic><topic>diabetes mellitus, type 2</topic><topic>Endocrinology & Metabolism</topic><topic>epidemiology</topic><topic>Life Sciences & Biomedicine</topic><topic>Original</topic><topic>prospective studies</topic><topic>Science & Technology</topic><topic>내과학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yeli</creatorcontrib><creatorcontrib>Zhu, Jingwen</creatorcontrib><creatorcontrib>Aroner, Sarah</creatorcontrib><creatorcontrib>Overvad, Kim</creatorcontrib><creatorcontrib>Cai, Tianxi</creatorcontrib><creatorcontrib>Yang, Ming</creatorcontrib><creatorcontrib>Tjonneland, Anne</creatorcontrib><creatorcontrib>Handberg, Aase</creatorcontrib><creatorcontrib>Jensen, Majken K.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Diabetes & metabolism journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yeli</au><au>Zhu, Jingwen</au><au>Aroner, Sarah</au><au>Overvad, Kim</au><au>Cai, Tianxi</au><au>Yang, Ming</au><au>Tjonneland, Anne</au><au>Handberg, Aase</au><au>Jensen, Majken K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women</atitle><jtitle>Diabetes & metabolism journal</jtitle><stitle>DIABETES METAB J</stitle><addtitle>Diabetes Metab J</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>44</volume><issue>1</issue><spage>134</spage><epage>142</epage><pages>134-142</pages><issn>2233-6079</issn><eissn>2233-6087</eissn><abstract>Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.
Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).
Results: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.
Conclusion: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.</abstract><cop>SEOUL</cop><pub>Korean Diabetes Assoc</pub><pmid>31701685</pmid><doi>10.4093/dmj.2018.0273</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1367-9537</orcidid><orcidid>https://orcid.org/0000-0003-3031-6199</orcidid><orcidid>https://orcid.org/0000-0001-6429-7921</orcidid><orcidid>https://orcid.org/0000-0003-4385-2097</orcidid><orcidid>https://orcid.org/0000-0001-5719-203X</orcidid><orcidid>https://orcid.org/0000-0003-4729-7545</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | adiposity biomarkers cd36 antigens diabetes mellitus, type 2 Endocrinology & Metabolism epidemiology Life Sciences & Biomedicine Original prospective studies Science & Technology 내과학 |
| title | Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women |
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