Duration of treatment for asymptomatic bacteriuria during pregnancy
Background A previous Cochrane systematic review has shown that antibiotic drug treatment of asymptomatic bacteriuria in pregnant women substantially decreases the risk of pyelonephritis and reduces the risk of preterm delivery. However, it is not clear whether single‐dose therapy is as effective as...
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| Veröffentlicht in: | Cochrane database of systematic reviews 2015-11, Vol.2015 (11), p.CD000491-CD000491 |
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| creator | Widmer, Mariana Lopez, Ivana Gülmezoglu, A Metin Mignini, Luciano Roganti, Ariel Widmer, Mariana |
| description | Background
A previous Cochrane systematic review has shown that antibiotic drug treatment of asymptomatic bacteriuria in pregnant women substantially decreases the risk of pyelonephritis and reduces the risk of preterm delivery. However, it is not clear whether single‐dose therapy is as effective as longer conventional antibiotic treatment.
Objectives
To assess the effects of different durations of treatment for asymptomatic bacteriuria in pregnancy.
Search methods
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2015) and reference lists of identified articles.
Selection criteria
Randomized and quasi‐randomized trials comparing antimicrobial therapeutic regimens that differed in duration (particularly comparing single dose with longer duration regimens) in pregnant women diagnosed with asymptomatic bacteriuria.
Data collection and analysis
Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We assessed the quality of the evidence using the GRADE approach.
Main results
We included 13 studies, involving 1622 women. All were comparisons of single‐dose treatment with short‐course (four‐ to seven‐day) treatments. The risk of bias of trials included in this review was largely unclear, and most trials were at high risk of performance bias. The quality of the evidence was assessed using the GRADE approach. When the any antibiotic agent was used, the 'no cure' rate for asymptomatic bacteriuria in pregnant women was slightly lower for the short‐course treatment over the single‐dose treatment, although there was evidence of statistical heterogeneity (average risk ratio (RR) 1.28, 95% confidence interval (CI) 0.87 to 1.88; women = 1502, studies = 13; I² = 56%; very low quality evidence). Data from only good quality trials also showed better cure rates with short (four‐ to seven‐day) regimens of the same microbial agent (average RR 1.72, 95% CI 1.27 to 2.33; women = 803, studies = two; I² = 0%; high quality evidence). There was no clear difference in the recurrence of asymptomatic bacteriuria rate between treatment and control groups, whether the same or different microbial agents were used (RR 1.13, 95% CI 0.77 to 1.66; 445 women studies = eight; I² = 0%; very low quality evidence). Differences were detected for low birthweight babies, favoring a short course (four‐ to seven‐day treatment) of the same microbial agent, although the data come from a single tri |
| doi_str_mv | 10.1002/14651858.CD000491.pub3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7043273</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1749996877</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4733-c8552051faabe7c9938e84086f64c7758e7f74f555c199c6a0de037265cd0a9b3</originalsourceid><addsrcrecordid>eNqFUUtPxCAYJEbjrqt_YdOjl65QCpSLiXZ9JZt40TOhlO7WtKVCq-m_l2YfWb144SOZ-WYGBoA5ggsEYXSDYkpQQpJFuoQQxhwt2j7DJ2A6AuGInB7dJ-DCuQ8IMeUROweTiBIKMWZTkC57K7vSNIEpgs5q2dW66YLC2EC6oW47U3tYBZlUnbZlb0sZ5P5s1kFr9bqRjRouwVkhK6evdnMG3h8f3tLncPX69JLerUIVM4xDlRASQYIKKTPNFOc40UkME1rQWDFGEs0KFheEEIU4V1TCXEPMfFaVQ8kzPAO3W13_1Frnyge1shKtLWtpB2FkKX4jTbkRa_MlGIxx5CPMwPVOwJrPXrtO1KVTuqpko03vBGIx55wmjHkq3VKVNc5ZXRxsEBRjA2LfgNg3MJqPHvPjkIe1_Zd7wv2W8F1WehDKqI31_v_o_nH5AZ6Jl9M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1749996877</pqid></control><display><type>article</type><title>Duration of treatment for asymptomatic bacteriuria during pregnancy</title><source>MEDLINE</source><source>Cochrane Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Widmer, Mariana ; Lopez, Ivana ; Gülmezoglu, A Metin ; Mignini, Luciano ; Roganti, Ariel ; Widmer, Mariana</creator><creatorcontrib>Widmer, Mariana ; Lopez, Ivana ; Gülmezoglu, A Metin ; Mignini, Luciano ; Roganti, Ariel ; Widmer, Mariana</creatorcontrib><description>Background
A previous Cochrane systematic review has shown that antibiotic drug treatment of asymptomatic bacteriuria in pregnant women substantially decreases the risk of pyelonephritis and reduces the risk of preterm delivery. However, it is not clear whether single‐dose therapy is as effective as longer conventional antibiotic treatment.
Objectives
To assess the effects of different durations of treatment for asymptomatic bacteriuria in pregnancy.
Search methods
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2015) and reference lists of identified articles.
Selection criteria
Randomized and quasi‐randomized trials comparing antimicrobial therapeutic regimens that differed in duration (particularly comparing single dose with longer duration regimens) in pregnant women diagnosed with asymptomatic bacteriuria.
Data collection and analysis
Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We assessed the quality of the evidence using the GRADE approach.
Main results
We included 13 studies, involving 1622 women. All were comparisons of single‐dose treatment with short‐course (four‐ to seven‐day) treatments. The risk of bias of trials included in this review was largely unclear, and most trials were at high risk of performance bias. The quality of the evidence was assessed using the GRADE approach. When the any antibiotic agent was used, the 'no cure' rate for asymptomatic bacteriuria in pregnant women was slightly lower for the short‐course treatment over the single‐dose treatment, although there was evidence of statistical heterogeneity (average risk ratio (RR) 1.28, 95% confidence interval (CI) 0.87 to 1.88; women = 1502, studies = 13; I² = 56%; very low quality evidence). Data from only good quality trials also showed better cure rates with short (four‐ to seven‐day) regimens of the same microbial agent (average RR 1.72, 95% CI 1.27 to 2.33; women = 803, studies = two; I² = 0%; high quality evidence). There was no clear difference in the recurrence of asymptomatic bacteriuria rate between treatment and control groups, whether the same or different microbial agents were used (RR 1.13, 95% CI 0.77 to 1.66; 445 women studies = eight; I² = 0%; very low quality evidence). Differences were detected for low birthweight babies, favoring a short course (four‐ to seven‐day treatment) of the same microbial agent, although the data come from a single trial (RR 1.65, 95% CI 1.06 to 2.57; 714 women; high quality evidence), but no differences were observed for preterm delivery (RR 1.17, 95% CI 0.77 to 1.78; women = 804; studies = three; I² = 23%; moderate quality) or pyelonephritis (RR 3.09, 95% CI 0.54 to 17.55; women = 102; studies = two; I² = 0%; very low quality evidence). Finally, single‐dose treatment of any microbial agent was associated with a decrease in reports of 'any side effects' (RR 0.70, 95% CI 0.56 to 0.88; 1460 women, studies = 12; I² = 9%; low quality evidence). Evidence was downgraded for risk of bias concerns in trials contributing data and for imprecise effect estimates (wide confidence intervals crossing the line of no effect, and in some cases, small studies with few events).
Authors' conclusions
A single‐dose regimen of antibiotics may be less effective than a short‐course (four‐ to seven‐day) regimen, but more evidence is needed from large trials measuring important outcomes, such as cure rate. Women with asymptomatic bacteriuria in pregnancy should be treated by the standard regimen of antibiotics until more data become available testing seven‐day treatment compared with shorter courses of three‐ or five‐day regimens.</description><identifier>ISSN: 1465-1858</identifier><identifier>EISSN: 1465-1858</identifier><identifier>EISSN: 1469-493X</identifier><identifier>DOI: 10.1002/14651858.CD000491.pub3</identifier><identifier>PMID: 26560337</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Anti‐Bacterial Agents ; Asymptomatic Infections ; Bacteriuria ; Bacteriuria - drug therapy ; Drug Administration Schedule ; Female ; Humans ; Infection during pregnancy ; Infectious disease ; Kidney disease ; Medicine General & Introductory Medical Sciences ; Pregnancy ; Pregnancy & childbirth ; Pregnancy Complications, Infectious ; Pregnancy Complications, Infectious - drug therapy ; Randomized Controlled Trials as Topic ; Treatment: asymptomatic infection ; Urinary tract infection ; Urinary tract infections</subject><ispartof>Cochrane database of systematic reviews, 2015-11, Vol.2015 (11), p.CD000491-CD000491</ispartof><rights>Copyright © 2015 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4733-c8552051faabe7c9938e84086f64c7758e7f74f555c199c6a0de037265cd0a9b3</citedby><cites>FETCH-LOGICAL-c4733-c8552051faabe7c9938e84086f64c7758e7f74f555c199c6a0de037265cd0a9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26560337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Widmer, Mariana</creatorcontrib><creatorcontrib>Lopez, Ivana</creatorcontrib><creatorcontrib>Gülmezoglu, A Metin</creatorcontrib><creatorcontrib>Mignini, Luciano</creatorcontrib><creatorcontrib>Roganti, Ariel</creatorcontrib><creatorcontrib>Widmer, Mariana</creatorcontrib><title>Duration of treatment for asymptomatic bacteriuria during pregnancy</title><title>Cochrane database of systematic reviews</title><addtitle>Cochrane Database Syst Rev</addtitle><description>Background
A previous Cochrane systematic review has shown that antibiotic drug treatment of asymptomatic bacteriuria in pregnant women substantially decreases the risk of pyelonephritis and reduces the risk of preterm delivery. However, it is not clear whether single‐dose therapy is as effective as longer conventional antibiotic treatment.
Objectives
To assess the effects of different durations of treatment for asymptomatic bacteriuria in pregnancy.
Search methods
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2015) and reference lists of identified articles.
Selection criteria
Randomized and quasi‐randomized trials comparing antimicrobial therapeutic regimens that differed in duration (particularly comparing single dose with longer duration regimens) in pregnant women diagnosed with asymptomatic bacteriuria.
Data collection and analysis
Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We assessed the quality of the evidence using the GRADE approach.
Main results
We included 13 studies, involving 1622 women. All were comparisons of single‐dose treatment with short‐course (four‐ to seven‐day) treatments. The risk of bias of trials included in this review was largely unclear, and most trials were at high risk of performance bias. The quality of the evidence was assessed using the GRADE approach. When the any antibiotic agent was used, the 'no cure' rate for asymptomatic bacteriuria in pregnant women was slightly lower for the short‐course treatment over the single‐dose treatment, although there was evidence of statistical heterogeneity (average risk ratio (RR) 1.28, 95% confidence interval (CI) 0.87 to 1.88; women = 1502, studies = 13; I² = 56%; very low quality evidence). Data from only good quality trials also showed better cure rates with short (four‐ to seven‐day) regimens of the same microbial agent (average RR 1.72, 95% CI 1.27 to 2.33; women = 803, studies = two; I² = 0%; high quality evidence). There was no clear difference in the recurrence of asymptomatic bacteriuria rate between treatment and control groups, whether the same or different microbial agents were used (RR 1.13, 95% CI 0.77 to 1.66; 445 women studies = eight; I² = 0%; very low quality evidence). Differences were detected for low birthweight babies, favoring a short course (four‐ to seven‐day treatment) of the same microbial agent, although the data come from a single trial (RR 1.65, 95% CI 1.06 to 2.57; 714 women; high quality evidence), but no differences were observed for preterm delivery (RR 1.17, 95% CI 0.77 to 1.78; women = 804; studies = three; I² = 23%; moderate quality) or pyelonephritis (RR 3.09, 95% CI 0.54 to 17.55; women = 102; studies = two; I² = 0%; very low quality evidence). Finally, single‐dose treatment of any microbial agent was associated with a decrease in reports of 'any side effects' (RR 0.70, 95% CI 0.56 to 0.88; 1460 women, studies = 12; I² = 9%; low quality evidence). Evidence was downgraded for risk of bias concerns in trials contributing data and for imprecise effect estimates (wide confidence intervals crossing the line of no effect, and in some cases, small studies with few events).
Authors' conclusions
A single‐dose regimen of antibiotics may be less effective than a short‐course (four‐ to seven‐day) regimen, but more evidence is needed from large trials measuring important outcomes, such as cure rate. Women with asymptomatic bacteriuria in pregnancy should be treated by the standard regimen of antibiotics until more data become available testing seven‐day treatment compared with shorter courses of three‐ or five‐day regimens.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti‐Bacterial Agents</subject><subject>Asymptomatic Infections</subject><subject>Bacteriuria</subject><subject>Bacteriuria - drug therapy</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Humans</subject><subject>Infection during pregnancy</subject><subject>Infectious disease</subject><subject>Kidney disease</subject><subject>Medicine General & Introductory Medical Sciences</subject><subject>Pregnancy</subject><subject>Pregnancy & childbirth</subject><subject>Pregnancy Complications, Infectious</subject><subject>Pregnancy Complications, Infectious - drug therapy</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Treatment: asymptomatic infection</subject><subject>Urinary tract infection</subject><subject>Urinary tract infections</subject><issn>1465-1858</issn><issn>1465-1858</issn><issn>1469-493X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RWY</sourceid><sourceid>EIF</sourceid><recordid>eNqFUUtPxCAYJEbjrqt_YdOjl65QCpSLiXZ9JZt40TOhlO7WtKVCq-m_l2YfWb144SOZ-WYGBoA5ggsEYXSDYkpQQpJFuoQQxhwt2j7DJ2A6AuGInB7dJ-DCuQ8IMeUROweTiBIKMWZTkC57K7vSNIEpgs5q2dW66YLC2EC6oW47U3tYBZlUnbZlb0sZ5P5s1kFr9bqRjRouwVkhK6evdnMG3h8f3tLncPX69JLerUIVM4xDlRASQYIKKTPNFOc40UkME1rQWDFGEs0KFheEEIU4V1TCXEPMfFaVQ8kzPAO3W13_1Frnyge1shKtLWtpB2FkKX4jTbkRa_MlGIxx5CPMwPVOwJrPXrtO1KVTuqpko03vBGIx55wmjHkq3VKVNc5ZXRxsEBRjA2LfgNg3MJqPHvPjkIe1_Zd7wv2W8F1WehDKqI31_v_o_nH5AZ6Jl9M</recordid><startdate>20151111</startdate><enddate>20151111</enddate><creator>Widmer, Mariana</creator><creator>Lopez, Ivana</creator><creator>Gülmezoglu, A Metin</creator><creator>Mignini, Luciano</creator><creator>Roganti, Ariel</creator><creator>Widmer, Mariana</creator><general>John Wiley & Sons, Ltd</general><scope>7PX</scope><scope>RWY</scope><scope>ZYTZH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151111</creationdate><title>Duration of treatment for asymptomatic bacteriuria during pregnancy</title><author>Widmer, Mariana ; Lopez, Ivana ; Gülmezoglu, A Metin ; Mignini, Luciano ; Roganti, Ariel ; Widmer, Mariana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4733-c8552051faabe7c9938e84086f64c7758e7f74f555c199c6a0de037265cd0a9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Anti‐Bacterial Agents</topic><topic>Asymptomatic Infections</topic><topic>Bacteriuria</topic><topic>Bacteriuria - drug therapy</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Humans</topic><topic>Infection during pregnancy</topic><topic>Infectious disease</topic><topic>Kidney disease</topic><topic>Medicine General & Introductory Medical Sciences</topic><topic>Pregnancy</topic><topic>Pregnancy & childbirth</topic><topic>Pregnancy Complications, Infectious</topic><topic>Pregnancy Complications, Infectious - drug therapy</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Treatment: asymptomatic infection</topic><topic>Urinary tract infection</topic><topic>Urinary tract infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Widmer, Mariana</creatorcontrib><creatorcontrib>Lopez, Ivana</creatorcontrib><creatorcontrib>Gülmezoglu, A Metin</creatorcontrib><creatorcontrib>Mignini, Luciano</creatorcontrib><creatorcontrib>Roganti, Ariel</creatorcontrib><creatorcontrib>Widmer, Mariana</creatorcontrib><collection>Wiley-Blackwell Cochrane Library</collection><collection>Cochrane Library</collection><collection>Cochrane Library (Open Aceess)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cochrane database of systematic reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Widmer, Mariana</au><au>Lopez, Ivana</au><au>Gülmezoglu, A Metin</au><au>Mignini, Luciano</au><au>Roganti, Ariel</au><au>Widmer, Mariana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duration of treatment for asymptomatic bacteriuria during pregnancy</atitle><jtitle>Cochrane database of systematic reviews</jtitle><addtitle>Cochrane Database Syst Rev</addtitle><date>2015-11-11</date><risdate>2015</risdate><volume>2015</volume><issue>11</issue><spage>CD000491</spage><epage>CD000491</epage><pages>CD000491-CD000491</pages><issn>1465-1858</issn><eissn>1465-1858</eissn><eissn>1469-493X</eissn><abstract>Background
A previous Cochrane systematic review has shown that antibiotic drug treatment of asymptomatic bacteriuria in pregnant women substantially decreases the risk of pyelonephritis and reduces the risk of preterm delivery. However, it is not clear whether single‐dose therapy is as effective as longer conventional antibiotic treatment.
Objectives
To assess the effects of different durations of treatment for asymptomatic bacteriuria in pregnancy.
Search methods
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 August 2015) and reference lists of identified articles.
Selection criteria
Randomized and quasi‐randomized trials comparing antimicrobial therapeutic regimens that differed in duration (particularly comparing single dose with longer duration regimens) in pregnant women diagnosed with asymptomatic bacteriuria.
Data collection and analysis
Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We assessed the quality of the evidence using the GRADE approach.
Main results
We included 13 studies, involving 1622 women. All were comparisons of single‐dose treatment with short‐course (four‐ to seven‐day) treatments. The risk of bias of trials included in this review was largely unclear, and most trials were at high risk of performance bias. The quality of the evidence was assessed using the GRADE approach. When the any antibiotic agent was used, the 'no cure' rate for asymptomatic bacteriuria in pregnant women was slightly lower for the short‐course treatment over the single‐dose treatment, although there was evidence of statistical heterogeneity (average risk ratio (RR) 1.28, 95% confidence interval (CI) 0.87 to 1.88; women = 1502, studies = 13; I² = 56%; very low quality evidence). Data from only good quality trials also showed better cure rates with short (four‐ to seven‐day) regimens of the same microbial agent (average RR 1.72, 95% CI 1.27 to 2.33; women = 803, studies = two; I² = 0%; high quality evidence). There was no clear difference in the recurrence of asymptomatic bacteriuria rate between treatment and control groups, whether the same or different microbial agents were used (RR 1.13, 95% CI 0.77 to 1.66; 445 women studies = eight; I² = 0%; very low quality evidence). Differences were detected for low birthweight babies, favoring a short course (four‐ to seven‐day treatment) of the same microbial agent, although the data come from a single trial (RR 1.65, 95% CI 1.06 to 2.57; 714 women; high quality evidence), but no differences were observed for preterm delivery (RR 1.17, 95% CI 0.77 to 1.78; women = 804; studies = three; I² = 23%; moderate quality) or pyelonephritis (RR 3.09, 95% CI 0.54 to 17.55; women = 102; studies = two; I² = 0%; very low quality evidence). Finally, single‐dose treatment of any microbial agent was associated with a decrease in reports of 'any side effects' (RR 0.70, 95% CI 0.56 to 0.88; 1460 women, studies = 12; I² = 9%; low quality evidence). Evidence was downgraded for risk of bias concerns in trials contributing data and for imprecise effect estimates (wide confidence intervals crossing the line of no effect, and in some cases, small studies with few events).
Authors' conclusions
A single‐dose regimen of antibiotics may be less effective than a short‐course (four‐ to seven‐day) regimen, but more evidence is needed from large trials measuring important outcomes, such as cure rate. Women with asymptomatic bacteriuria in pregnancy should be treated by the standard regimen of antibiotics until more data become available testing seven‐day treatment compared with shorter courses of three‐ or five‐day regimens.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>26560337</pmid><doi>10.1002/14651858.CD000491.pub3</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cochrane Library; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Anti‐Bacterial Agents Asymptomatic Infections Bacteriuria Bacteriuria - drug therapy Drug Administration Schedule Female Humans Infection during pregnancy Infectious disease Kidney disease Medicine General & Introductory Medical Sciences Pregnancy Pregnancy & childbirth Pregnancy Complications, Infectious Pregnancy Complications, Infectious - drug therapy Randomized Controlled Trials as Topic Treatment: asymptomatic infection Urinary tract infection Urinary tract infections |
| title | Duration of treatment for asymptomatic bacteriuria during pregnancy |
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