Aristolochic Acid-Induced Nephrotoxicity: Molecular Mechanisms and Potential Protective Approaches

Aristolochic acid (AA) is a generic term that describes a group of structurally related compounds found in the Aristolochiaceae plants family. These plants have been used for decades to treat various diseases. However, the consumption of products derived from plants containing AA has been associated...

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Veröffentlicht in:	International journal of molecular sciences 2020-02, Vol.21 (3), p.1157
Hauptverfasser:	Anger, Etienne Empweb, Yu, Feng, Li, Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Aristolochic acid Aristolochic Acids - toxicity Bladder cancer Carcinogenesis Carcinogens Carcinogens - toxicity DNA Adducts Enzymes Flowers & plants Humans Kidney diseases Kidney Neoplasms - chemically induced Kidney Neoplasms - prevention & control Metabolism Metabolites Molecular modelling Mutagens - toxicity Mutation Nephropathy Review Toxicity Tumor Suppressor Protein p53 - genetics Urothelial carcinoma
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