Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neuro...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-30 |
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| creator | Mohd Sairazi, Nur Shafika Sirajudeen, Kuttulebbai N. S. |
| description | In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases. |
| doi_str_mv | 10.1155/2020/6565396 |
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S.</creator><contributor>Satou, Tadaaki ; Tadaaki Satou</contributor><creatorcontrib>Mohd Sairazi, Nur Shafika ; Sirajudeen, Kuttulebbai N. S. ; Satou, Tadaaki ; Tadaaki Satou</creatorcontrib><description>In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/6565396</identifier><identifier>PMID: 32148547</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alzheimer's disease ; Amino acids ; Amyotrophic lateral sclerosis ; Apoptosis ; Bioactive compounds ; Cell death ; Diabetes mellitus ; Disease ; Fungi ; Health aspects ; Huntingtons disease ; Hypertension ; Movement disorders ; Natural products ; Nervous system diseases ; Neurodegeneration ; Neurodegenerative diseases ; Neurons ; Neuroprotection ; Neuroprotective agents ; Parkinson's disease ; Prevention ; Review ; Structure-function relationships</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-30</ispartof><rights>Copyright © 2020 Nur Shafika Mohd Sairazi and K. N. S. Sirajudeen.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Nur Shafika Mohd Sairazi and K. N. S. Sirajudeen. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Nur Shafika Mohd Sairazi and K. N. S. 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S.</creatorcontrib><title>Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. 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This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32148547</pmid><doi>10.1155/2020/6565396</doi><tpages>30</tpages><orcidid>https://orcid.org/0000-0002-8546-3412</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Alzheimer's disease Amino acids Amyotrophic lateral sclerosis Apoptosis Bioactive compounds Cell death Diabetes mellitus Disease Fungi Health aspects Huntingtons disease Hypertension Movement disorders Natural products Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurons Neuroprotection Neuroprotective agents Parkinson's disease Prevention Review Structure-function relationships |
| title | Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases |
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