Mandibular Advancement Devices Prevent the Adverse Cardiac Effects of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS)
Although considerable research highlights the interactions between obstructive sleep apnea-hypopnea syndrome (OSAHS) and cardiovascular diseases, the effect of mandibular advancement device (MAD) treatment on cardiovascular complications in OSAHS patients remains unclear. We evaluated the effect of...
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| description | Although considerable research highlights the interactions between obstructive sleep apnea-hypopnea syndrome (OSAHS) and cardiovascular diseases, the effect of mandibular advancement device (MAD) treatment on cardiovascular complications in OSAHS patients remains unclear. We evaluated the effect of OSAHS treatment with MADs on the myocardium. All methods in this study were in accordance with relevant guidelines and regulations of the medical ethics committee in Hospital of Stomatology, Hebei Medical University approved the work. Thirty New Zealand rabbits were randomized into three groups: the control group, Group OSAHS, and Group MAD. Hydrophilic polyacrylamide gel was injected into the soft palate of the rabbits to induce OSAHS. In Group MAD, a MAD was positioned after OSAHS induction. All animals were induced to sleep in a supine position for 4–6 h/day for 8 weeks. Echocardiography was used to determine the structure and function of the heart. The histological changes were detected by optical microscopy and transmission electron microscopy (TEM). The levels of ET-1(endothelin-1) and Ang II (Angiotensin II) in the plasma were measured by an enzyme-linked immunosorbent assay (ELISA). The expression of ET-1 mRNA in heart tissue was detected by RT-PCR. Histological abnormalities, left ventricular hypertrophy, and left ventricular dysfunctions were demonstrated in Group OSAHS, and the abnormities were rescued with MAD treatment. Higher levels of plasma ET-1 and Ang II and elevated expression of ET-1 mRNA in cardiac tissue were detected in Group OSAHS compared with Group MAD and the control group. The blood oxygen saturation was negatively correlated with the levels of ET-1 and Ang II. OSAHS-induced elevated levels of ET-1 and Ang II may be attributed to myocardial structural abnormalities and dysfunction. Early treatment of MADs may play an important role in preventing myocardial damage in OSAHS rabbit model. |
| doi_str_mv | 10.1038/s41598-020-60034-1 |
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We evaluated the effect of OSAHS treatment with MADs on the myocardium. All methods in this study were in accordance with relevant guidelines and regulations of the medical ethics committee in Hospital of Stomatology, Hebei Medical University approved the work. Thirty New Zealand rabbits were randomized into three groups: the control group, Group OSAHS, and Group MAD. Hydrophilic polyacrylamide gel was injected into the soft palate of the rabbits to induce OSAHS. In Group MAD, a MAD was positioned after OSAHS induction. All animals were induced to sleep in a supine position for 4–6 h/day for 8 weeks. Echocardiography was used to determine the structure and function of the heart. The histological changes were detected by optical microscopy and transmission electron microscopy (TEM). The levels of ET-1(endothelin-1) and Ang II (Angiotensin II) in the plasma were measured by an enzyme-linked immunosorbent assay (ELISA). The expression of ET-1 mRNA in heart tissue was detected by RT-PCR. Histological abnormalities, left ventricular hypertrophy, and left ventricular dysfunctions were demonstrated in Group OSAHS, and the abnormities were rescued with MAD treatment. Higher levels of plasma ET-1 and Ang II and elevated expression of ET-1 mRNA in cardiac tissue were detected in Group OSAHS compared with Group MAD and the control group. The blood oxygen saturation was negatively correlated with the levels of ET-1 and Ang II. OSAHS-induced elevated levels of ET-1 and Ang II may be attributed to myocardial structural abnormalities and dysfunction. Early treatment of MADs may play an important role in preventing myocardial damage in OSAHS rabbit model.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-60034-1</identifier><identifier>PMID: 32098974</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/28 ; 13 ; 13/21 ; 14/63 ; 38 ; 38/22 ; 45/22 ; 631/337/572/2102 ; 631/443/1784 ; 631/535/1258/1259 ; 82/80 ; 96/21 ; Acrylic Resins - toxicity ; Angiotensin ; Angiotensin II ; Angiotensin II - blood ; Animals ; Apnea ; Cardiovascular diseases ; Cytokines - metabolism ; Echocardiography ; Endothelin 1 ; Endothelin-1 - blood ; Endothelin-1 - genetics ; Endothelin-1 - metabolism ; Enzyme-Linked Immunosorbent Assay ; Gene expression ; Heart ; Heart - physiopathology ; Humanities and Social Sciences ; Hypertrophy ; Light microscopy ; Male ; Mandible ; Microscopy ; mRNA ; multidisciplinary ; Myocardium ; Myocardium - metabolism ; Myocardium - pathology ; Occlusal Splints ; Palate ; Polyacrylamide ; Polymerase chain reaction ; Polysomnography ; Rabbits ; RNA, Messenger - metabolism ; Science ; Science (multidisciplinary) ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - chemically induced ; Sleep Apnea, Obstructive - therapy ; Sleep disorders ; Structure-function relationships ; Transmission electron microscopy ; Ventricle ; Ventricular Dysfunction, Left - pathology</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.3394, Article 3394</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-83aaf87fe8db34bc7ba60df0853852f160fa35be9e89fcd2245389b5a9f65ff93</citedby><cites>FETCH-LOGICAL-c474t-83aaf87fe8db34bc7ba60df0853852f160fa35be9e89fcd2245389b5a9f65ff93</cites><orcidid>0000-0002-8891-5103</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042252/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042252/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51555,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32098974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chunyan</creatorcontrib><creatorcontrib>Kang, Wenjing</creatorcontrib><creatorcontrib>Zhang, Shilong</creatorcontrib><creatorcontrib>Qiao, Xing</creatorcontrib><creatorcontrib>Yang, Xiuchun</creatorcontrib><creatorcontrib>Zhou, Zheng</creatorcontrib><creatorcontrib>Lu, Haiyan</creatorcontrib><title>Mandibular Advancement Devices Prevent the Adverse Cardiac Effects of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS)</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Although considerable research highlights the interactions between obstructive sleep apnea-hypopnea syndrome (OSAHS) and cardiovascular diseases, the effect of mandibular advancement device (MAD) treatment on cardiovascular complications in OSAHS patients remains unclear. We evaluated the effect of OSAHS treatment with MADs on the myocardium. All methods in this study were in accordance with relevant guidelines and regulations of the medical ethics committee in Hospital of Stomatology, Hebei Medical University approved the work. Thirty New Zealand rabbits were randomized into three groups: the control group, Group OSAHS, and Group MAD. Hydrophilic polyacrylamide gel was injected into the soft palate of the rabbits to induce OSAHS. In Group MAD, a MAD was positioned after OSAHS induction. All animals were induced to sleep in a supine position for 4–6 h/day for 8 weeks. Echocardiography was used to determine the structure and function of the heart. The histological changes were detected by optical microscopy and transmission electron microscopy (TEM). The levels of ET-1(endothelin-1) and Ang II (Angiotensin II) in the plasma were measured by an enzyme-linked immunosorbent assay (ELISA). The expression of ET-1 mRNA in heart tissue was detected by RT-PCR. Histological abnormalities, left ventricular hypertrophy, and left ventricular dysfunctions were demonstrated in Group OSAHS, and the abnormities were rescued with MAD treatment. Higher levels of plasma ET-1 and Ang II and elevated expression of ET-1 mRNA in cardiac tissue were detected in Group OSAHS compared with Group MAD and the control group. The blood oxygen saturation was negatively correlated with the levels of ET-1 and Ang II. OSAHS-induced elevated levels of ET-1 and Ang II may be attributed to myocardial structural abnormalities and dysfunction. Early treatment of MADs may play an important role in preventing myocardial damage in OSAHS rabbit model.</description><subject>101/28</subject><subject>13</subject><subject>13/21</subject><subject>14/63</subject><subject>38</subject><subject>38/22</subject><subject>45/22</subject><subject>631/337/572/2102</subject><subject>631/443/1784</subject><subject>631/535/1258/1259</subject><subject>82/80</subject><subject>96/21</subject><subject>Acrylic Resins - toxicity</subject><subject>Angiotensin</subject><subject>Angiotensin II</subject><subject>Angiotensin II - blood</subject><subject>Animals</subject><subject>Apnea</subject><subject>Cardiovascular diseases</subject><subject>Cytokines - metabolism</subject><subject>Echocardiography</subject><subject>Endothelin 1</subject><subject>Endothelin-1 - blood</subject><subject>Endothelin-1 - genetics</subject><subject>Endothelin-1 - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Gene expression</subject><subject>Heart</subject><subject>Heart - physiopathology</subject><subject>Humanities and Social Sciences</subject><subject>Hypertrophy</subject><subject>Light microscopy</subject><subject>Male</subject><subject>Mandible</subject><subject>Microscopy</subject><subject>mRNA</subject><subject>multidisciplinary</subject><subject>Myocardium</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Occlusal Splints</subject><subject>Palate</subject><subject>Polyacrylamide</subject><subject>Polymerase chain reaction</subject><subject>Polysomnography</subject><subject>Rabbits</subject><subject>RNA, Messenger - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - chemically induced</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep disorders</subject><subject>Structure-function relationships</subject><subject>Transmission electron microscopy</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - 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toxicity</topic><topic>Angiotensin</topic><topic>Angiotensin II</topic><topic>Angiotensin II - blood</topic><topic>Animals</topic><topic>Apnea</topic><topic>Cardiovascular diseases</topic><topic>Cytokines - metabolism</topic><topic>Echocardiography</topic><topic>Endothelin 1</topic><topic>Endothelin-1 - blood</topic><topic>Endothelin-1 - genetics</topic><topic>Endothelin-1 - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Gene expression</topic><topic>Heart</topic><topic>Heart - physiopathology</topic><topic>Humanities and Social Sciences</topic><topic>Hypertrophy</topic><topic>Light microscopy</topic><topic>Male</topic><topic>Mandible</topic><topic>Microscopy</topic><topic>mRNA</topic><topic>multidisciplinary</topic><topic>Myocardium</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Occlusal Splints</topic><topic>Palate</topic><topic>Polyacrylamide</topic><topic>Polymerase chain reaction</topic><topic>Polysomnography</topic><topic>Rabbits</topic><topic>RNA, Messenger - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - chemically induced</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep disorders</topic><topic>Structure-function relationships</topic><topic>Transmission electron microscopy</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chunyan</creatorcontrib><creatorcontrib>Kang, Wenjing</creatorcontrib><creatorcontrib>Zhang, Shilong</creatorcontrib><creatorcontrib>Qiao, Xing</creatorcontrib><creatorcontrib>Yang, Xiuchun</creatorcontrib><creatorcontrib>Zhou, Zheng</creatorcontrib><creatorcontrib>Lu, Haiyan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chunyan</au><au>Kang, Wenjing</au><au>Zhang, Shilong</au><au>Qiao, Xing</au><au>Yang, Xiuchun</au><au>Zhou, Zheng</au><au>Lu, Haiyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mandibular Advancement Devices Prevent the Adverse Cardiac Effects of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS)</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-02-25</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>3394</spage><pages>3394-</pages><artnum>3394</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Although considerable research highlights the interactions between obstructive sleep apnea-hypopnea syndrome (OSAHS) and cardiovascular diseases, the effect of mandibular advancement device (MAD) treatment on cardiovascular complications in OSAHS patients remains unclear. We evaluated the effect of OSAHS treatment with MADs on the myocardium. All methods in this study were in accordance with relevant guidelines and regulations of the medical ethics committee in Hospital of Stomatology, Hebei Medical University approved the work. Thirty New Zealand rabbits were randomized into three groups: the control group, Group OSAHS, and Group MAD. Hydrophilic polyacrylamide gel was injected into the soft palate of the rabbits to induce OSAHS. In Group MAD, a MAD was positioned after OSAHS induction. All animals were induced to sleep in a supine position for 4–6 h/day for 8 weeks. Echocardiography was used to determine the structure and function of the heart. The histological changes were detected by optical microscopy and transmission electron microscopy (TEM). The levels of ET-1(endothelin-1) and Ang II (Angiotensin II) in the plasma were measured by an enzyme-linked immunosorbent assay (ELISA). The expression of ET-1 mRNA in heart tissue was detected by RT-PCR. Histological abnormalities, left ventricular hypertrophy, and left ventricular dysfunctions were demonstrated in Group OSAHS, and the abnormities were rescued with MAD treatment. Higher levels of plasma ET-1 and Ang II and elevated expression of ET-1 mRNA in cardiac tissue were detected in Group OSAHS compared with Group MAD and the control group. The blood oxygen saturation was negatively correlated with the levels of ET-1 and Ang II. OSAHS-induced elevated levels of ET-1 and Ang II may be attributed to myocardial structural abnormalities and dysfunction. Early treatment of MADs may play an important role in preventing myocardial damage in OSAHS rabbit model.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32098974</pmid><doi>10.1038/s41598-020-60034-1</doi><orcidid>https://orcid.org/0000-0002-8891-5103</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 101/28 13 13/21 14/63 38 38/22 45/22 631/337/572/2102 631/443/1784 631/535/1258/1259 82/80 96/21 Acrylic Resins - toxicity Angiotensin Angiotensin II Angiotensin II - blood Animals Apnea Cardiovascular diseases Cytokines - metabolism Echocardiography Endothelin 1 Endothelin-1 - blood Endothelin-1 - genetics Endothelin-1 - metabolism Enzyme-Linked Immunosorbent Assay Gene expression Heart Heart - physiopathology Humanities and Social Sciences Hypertrophy Light microscopy Male Mandible Microscopy mRNA multidisciplinary Myocardium Myocardium - metabolism Myocardium - pathology Occlusal Splints Palate Polyacrylamide Polymerase chain reaction Polysomnography Rabbits RNA, Messenger - metabolism Science Science (multidisciplinary) Sleep Sleep apnea Sleep Apnea, Obstructive - chemically induced Sleep Apnea, Obstructive - therapy Sleep disorders Structure-function relationships Transmission electron microscopy Ventricle Ventricular Dysfunction, Left - pathology |
| title | Mandibular Advancement Devices Prevent the Adverse Cardiac Effects of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) |
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