Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2
Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals' lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show tha...
Gespeichert in:
| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2020-02, Vol.12 (3), p.2840-2856 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2856 |
|---|---|
| container_issue | 3 |
| container_start_page | 2840 |
| container_title | Aging (Albany, NY.) |
| container_volume | 12 |
| creator | Wan, Qin-Li Fu, Xiaodie Dai, Wenyu Yang, Jing Luo, Zhenhuan Meng, Xiao Liu, Xiao Zhong, Ruowei Yang, Hengwen Zhou, Qinghua |
| description | Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals' lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show that uric acid, an end product of purine metabolism, enhances the resistance of oxidative stress and extends the life span of
. We show that uric acid enhances a variety of pathways and leads to the upregulation of genes that are required for uric acid-mediated life span extension. We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. We also show that uric acid induced life span extension by regulating the reproductive signaling and insulin/IGF-1 signaling (IIS) pathways. In addition, we find that mitochondrial function plays an important role in uric acid-mediated life span extension. Taken together, these data suggest that uric acid prolongs the life span of
, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1. |
| doi_str_mv | 10.18632/aging.102781 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7041755</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>32074508</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-c239eb7d0852262dd4f48ffcb7a0eaa0ab608dc2591285004b7c972663f720133</originalsourceid><addsrcrecordid>eNpVkd9KwzAUxoMobk4vvZW8QLckTZr0RhjTqigbqAPvSpqkXWRLR9INfQGf29LpnDfnD-c7v3PgA-ASoyEWSUxGsrKuGmJEuMBHoI9TyiLKRHp8UPfAWQjvCCWM0eQU9GKCOGVI9MHX3FsFpbIaWqc3ygQYGm9CgG2woZFOGSidhuajMU4H2CwMXNrSwLCWru18vakWLaCxW9m0n3SCP8S6dsHAsp3XHt6Mswgno2z2NuuYL4_TCI-mzxk5ByelXAZz8ZMHYJ7dvk7uo6fZ3cNk_BQpyuImUiROTcE1EoyQhGhNSyrKUhVcIiMlkkWChFaEpZgIhhAtuEo5SZK45AThOB6A6x13vSlWRivjGi-X-drblfSfeS1t_n_i7CKv6m3OEcWcsRYQ7QDK1yF4U-53Mco7Q_LOkHxnSKu_Ojy4V_86EH8DMh2Ixw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wan, Qin-Li ; Fu, Xiaodie ; Dai, Wenyu ; Yang, Jing ; Luo, Zhenhuan ; Meng, Xiao ; Liu, Xiao ; Zhong, Ruowei ; Yang, Hengwen ; Zhou, Qinghua</creator><creatorcontrib>Wan, Qin-Li ; Fu, Xiaodie ; Dai, Wenyu ; Yang, Jing ; Luo, Zhenhuan ; Meng, Xiao ; Liu, Xiao ; Zhong, Ruowei ; Yang, Hengwen ; Zhou, Qinghua</creatorcontrib><description>Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals' lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show that uric acid, an end product of purine metabolism, enhances the resistance of oxidative stress and extends the life span of
. We show that uric acid enhances a variety of pathways and leads to the upregulation of genes that are required for uric acid-mediated life span extension. We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. We also show that uric acid induced life span extension by regulating the reproductive signaling and insulin/IGF-1 signaling (IIS) pathways. In addition, we find that mitochondrial function plays an important role in uric acid-mediated life span extension. Taken together, these data suggest that uric acid prolongs the life span of
, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.102781</identifier><identifier>PMID: 32074508</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins - genetics ; Caenorhabditis elegans Proteins - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Forkhead Transcription Factors - genetics ; Forkhead Transcription Factors - metabolism ; Gene Expression Regulation - drug effects ; Herbicides - toxicity ; Longevity - drug effects ; NF-E2-Related Factor 2 - genetics ; NF-E2-Related Factor 2 - metabolism ; Paraquat - toxicity ; Research Paper ; Stress, Physiological - drug effects ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Uric Acid - pharmacology</subject><ispartof>Aging (Albany, NY.), 2020-02, Vol.12 (3), p.2840-2856</ispartof><rights>Copyright © 2020 Wan et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-c239eb7d0852262dd4f48ffcb7a0eaa0ab608dc2591285004b7c972663f720133</citedby><cites>FETCH-LOGICAL-c453t-c239eb7d0852262dd4f48ffcb7a0eaa0ab608dc2591285004b7c972663f720133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041755/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041755/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32074508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan, Qin-Li</creatorcontrib><creatorcontrib>Fu, Xiaodie</creatorcontrib><creatorcontrib>Dai, Wenyu</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Luo, Zhenhuan</creatorcontrib><creatorcontrib>Meng, Xiao</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Zhong, Ruowei</creatorcontrib><creatorcontrib>Yang, Hengwen</creatorcontrib><creatorcontrib>Zhou, Qinghua</creatorcontrib><title>Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals' lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show that uric acid, an end product of purine metabolism, enhances the resistance of oxidative stress and extends the life span of
. We show that uric acid enhances a variety of pathways and leads to the upregulation of genes that are required for uric acid-mediated life span extension. We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. We also show that uric acid induced life span extension by regulating the reproductive signaling and insulin/IGF-1 signaling (IIS) pathways. In addition, we find that mitochondrial function plays an important role in uric acid-mediated life span extension. Taken together, these data suggest that uric acid prolongs the life span of
, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1.</description><subject>Animals</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans Proteins - genetics</subject><subject>Caenorhabditis elegans Proteins - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Herbicides - toxicity</subject><subject>Longevity - drug effects</subject><subject>NF-E2-Related Factor 2 - genetics</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Paraquat - toxicity</subject><subject>Research Paper</subject><subject>Stress, Physiological - drug effects</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Uric Acid - pharmacology</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd9KwzAUxoMobk4vvZW8QLckTZr0RhjTqigbqAPvSpqkXWRLR9INfQGf29LpnDfnD-c7v3PgA-ASoyEWSUxGsrKuGmJEuMBHoI9TyiLKRHp8UPfAWQjvCCWM0eQU9GKCOGVI9MHX3FsFpbIaWqc3ygQYGm9CgG2woZFOGSidhuajMU4H2CwMXNrSwLCWru18vakWLaCxW9m0n3SCP8S6dsHAsp3XHt6Mswgno2z2NuuYL4_TCI-mzxk5ByelXAZz8ZMHYJ7dvk7uo6fZ3cNk_BQpyuImUiROTcE1EoyQhGhNSyrKUhVcIiMlkkWChFaEpZgIhhAtuEo5SZK45AThOB6A6x13vSlWRivjGi-X-drblfSfeS1t_n_i7CKv6m3OEcWcsRYQ7QDK1yF4U-53Mco7Q_LOkHxnSKu_Ojy4V_86EH8DMh2Ixw</recordid><startdate>20200212</startdate><enddate>20200212</enddate><creator>Wan, Qin-Li</creator><creator>Fu, Xiaodie</creator><creator>Dai, Wenyu</creator><creator>Yang, Jing</creator><creator>Luo, Zhenhuan</creator><creator>Meng, Xiao</creator><creator>Liu, Xiao</creator><creator>Zhong, Ruowei</creator><creator>Yang, Hengwen</creator><creator>Zhou, Qinghua</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200212</creationdate><title>Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2</title><author>Wan, Qin-Li ; Fu, Xiaodie ; Dai, Wenyu ; Yang, Jing ; Luo, Zhenhuan ; Meng, Xiao ; Liu, Xiao ; Zhong, Ruowei ; Yang, Hengwen ; Zhou, Qinghua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-c239eb7d0852262dd4f48ffcb7a0eaa0ab608dc2591285004b7c972663f720133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans Proteins - genetics</topic><topic>Caenorhabditis elegans Proteins - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Herbicides - toxicity</topic><topic>Longevity - drug effects</topic><topic>NF-E2-Related Factor 2 - genetics</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Paraquat - toxicity</topic><topic>Research Paper</topic><topic>Stress, Physiological - drug effects</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Uric Acid - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Wan, Qin-Li</creatorcontrib><creatorcontrib>Fu, Xiaodie</creatorcontrib><creatorcontrib>Dai, Wenyu</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Luo, Zhenhuan</creatorcontrib><creatorcontrib>Meng, Xiao</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Zhong, Ruowei</creatorcontrib><creatorcontrib>Yang, Hengwen</creatorcontrib><creatorcontrib>Zhou, Qinghua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wan, Qin-Li</au><au>Fu, Xiaodie</au><au>Dai, Wenyu</au><au>Yang, Jing</au><au>Luo, Zhenhuan</au><au>Meng, Xiao</au><au>Liu, Xiao</au><au>Zhong, Ruowei</au><au>Yang, Hengwen</au><au>Zhou, Qinghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2020-02-12</date><risdate>2020</risdate><volume>12</volume><issue>3</issue><spage>2840</spage><epage>2856</epage><pages>2840-2856</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites have been identified that modulate aging, and uric acid levels are positively correlated with mammals' lifespan. However, the molecular mechanisms underlying this are largely undefined. Here we show that uric acid, an end product of purine metabolism, enhances the resistance of oxidative stress and extends the life span of
. We show that uric acid enhances a variety of pathways and leads to the upregulation of genes that are required for uric acid-mediated life span extension. We find that the transcription factors DAF-16/FOXO, SKN-1/NRF2 and HSF-1 contribute to the beneficial longevity conferred by uric acid. We also show that uric acid induced life span extension by regulating the reproductive signaling and insulin/IGF-1 signaling (IIS) pathways. In addition, we find that mitochondrial function plays an important role in uric acid-mediated life span extension. Taken together, these data suggest that uric acid prolongs the life span of
, in part, because of its antioxidative activity, which in turn regulates the IIS and the reproductive signaling pathways, thereby activating the function of the transcription factors DAF-16, HSF-1 and SKN-1.</abstract><cop>United States</cop><pub>Impact Journals</pub><pmid>32074508</pmid><doi>10.18632/aging.102781</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1945-4589 |
| ispartof | Aging (Albany, NY.), 2020-02, Vol.12 (3), p.2840-2856 |
| issn | 1945-4589 1945-4589 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7041755 |
| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation - drug effects Herbicides - toxicity Longevity - drug effects NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Paraquat - toxicity Research Paper Stress, Physiological - drug effects Transcription Factors - genetics Transcription Factors - metabolism Uric Acid - pharmacology |
| title | Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T11%3A35%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Uric%20acid%20induces%20stress%20resistance%20and%20extends%20the%20life%20span%20through%20activating%20the%20stress%20response%20factor%20DAF-16/FOXO%20and%20SKN-1/NRF2&rft.jtitle=Aging%20(Albany,%20NY.)&rft.au=Wan,%20Qin-Li&rft.date=2020-02-12&rft.volume=12&rft.issue=3&rft.spage=2840&rft.epage=2856&rft.pages=2840-2856&rft.issn=1945-4589&rft.eissn=1945-4589&rft_id=info:doi/10.18632/aging.102781&rft_dat=%3Cpubmed_cross%3E32074508%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/32074508&rfr_iscdi=true |