Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis

Podosomes are compartmentalized actin-rich adhesions, defined by their ability to locally secrete proteases and remodel extracellular matrix. Matrix remodeling by endothelial podosomes facilitates invasion and thereby vessel formation. However, the mechanisms underlying endothelial podosome formatio...

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Veröffentlicht in:	The Journal of cell biology 2020-02, Vol.219 (2)
Hauptverfasser:	Collins, Kerrie B, Kang, Hojin, Matsche, Jacob, Klomp, Jennifer E, Rehman, Jalees, Malik, Asrar B, Karginov, Andrei V
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - genetics Adaptor Proteins, Vesicular Transport - genetics Angiogenesis Animals Blood vessels Cell Cycle Proteins - genetics Cell Movement - genetics Cells, Cultured Cytoskeleton Endothelial cells Endothelial Cells - metabolism Extracellular matrix Extracellular Matrix - genetics Humans Maturation Morphogenesis - genetics Neovascularization, Physiologic - genetics Organelles Podosomes - genetics Scaffolding Septin Septins - genetics
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