PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation

The C9orf72 protein is required for normal lysosome function. In support of such functions, C9orf72 forms a heterotrimeric complex with SMCR8 and WDR41 that is recruited to lysosomes when amino acids are scarce. These properties raise questions about the identity of the lysosomal binding partner of...

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Veröffentlicht in:	The Journal of cell biology 2020-01, Vol.219 (1), p.1
Hauptverfasser:	Amick, Joseph, Tharkeshwar, Arun Kumar, Talaia, Gabriel, Ferguson, Shawn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid starvation Amino acids Arginine Cations Chemoreception Histidine Lysine Lysosomes Recruitment
Online-Zugang:	Volltext
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