Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity

Steroid hormones are pivotal modulators of pathophysiological processes in many organs, where they interact with nuclear receptors to regulate gene transcription. However, our understanding of hormone action at the single cell level remains incomplete. Here, we focused on estrogen stimulation of the...

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Veröffentlicht in:	Nucleic acids research 2020-02, Vol.48 (4), p.1800-1810
Hauptverfasser:	Stossi, Fabio, Dandekar, Radhika D, Mancini, Maureen G, Gu, Guowei, Fuqua, Suzanne A W, Nardone, Agostina, De Angelis, Carmine, Fu, Xiaoyong, Schiff, Rachel, Bedford, Mark T, Xu, Wei, Johansson, Hans E, Stephan, Clifford C, Mancini, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Estrogens - metabolism Gene regulation, Chromatin and Epigenetics Gonadal Steroid Hormones - genetics Histone Acetyltransferases - genetics Humans Molecular Conformation Neoplasm Proteins - genetics Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Protein Binding - genetics Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - genetics Proto-Oncogene Proteins c-myc - genetics Single-Cell Analysis Transcription, Genetic
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