A Small Number of HER2 Redirected CAR T Cells Significantly Improves Immune Response of Adoptively Transferred Mouse Lymphocytes against Human Breast Cancer Xenografts

HER2 positive JIMT-1 breast tumors are resistant to trastuzumab treatment in vitro and develop resistance to trastuzumab in vivo in SCID mice. We explored whether these resistant tumors could still be eliminated by T cells redirected by a second-generation chimeric antigen receptor (CAR) containing...

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Veröffentlicht in:	International journal of molecular sciences 2020-02, Vol.21 (3), p.1039
Hauptverfasser:	Tóth, Gábor, Szöllősi, János, Abken, Hinrich, Vereb, György, Szöőr, Árpád
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Breast cancer Cancer therapies CD28 antigen Chimeric antigen receptors Clinical trials Cytokines Cytolytic activity Cytotoxicity Dosage ErbB-2 protein Lymphocytes Lymphocytes T Monoclonal antibodies Patients Remission Solid tumors Targeted cancer therapy Trastuzumab Tumors Xenografts Xenotransplantation
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