Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators
Older men sustain excess bone mineral density (BMD) declines after hip fracture; however, BMD provides no information on mechanical structure and strength. The aim was to assess whether changes in hip bone geometry in older men after hip fracture differ than that expected with aging. Two cohorts wer...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2020-03, Vol.132, p.115187-115187, Article 115187 |
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| creator | Rathbun, Alan M. Magaziner, Jay Shardell, Michelle D. Beck, Thomas J. Yerges-Armstrong, Laura M. Orwig, Denise Hicks, Gregory E. Ryan, Alice S. Hochberg, Marc C. |
| description | Older men sustain excess bone mineral density (BMD) declines after hip fracture; however, BMD provides no information on mechanical structure and strength. The aim was to assess whether changes in hip bone geometry in older men after hip fracture differ than that expected with aging. Two cohorts were used: Baltimore Hip Studies 7th cohort (BHS-7) and Baltimore Men's Osteoporosis Study (MOST). The sample (N = 170) included older Caucasian men with hip fracture that were propensity score matched (1:1) to community-dwelling non-fractured comparators. Hip Structural Analysis (HSA) calculated aerial BMD and metrics of bone structural strength: cross-sectional bone area (CSA), cortical outer diameter (OD), section modulus (SM), and centroid position (CP). Mixed-effect models estimated changes in HSA parameters and adjusted robust regression models evaluated between-cohort differences in annual percent change at the narrow neck (NN), intertrochanteric (IT), and femoral shaft (FS). Hip fracture was associated with statistically greater declines in NN CSA (β = −2.818; 95% CI: −3.300%, −2.336%), SM (β = −1.896%; 95% CI: −2.711%, −1.080%) and CP (β = −0.884%; 95% CI: −0.889%, −0.880%) and significantly larger increases in NN OD (β = 0.187%; 95% CI: 0.185%, 0.190%). Differences in IT HSA parameters were like the NN but larger in magnitude, while there were favorable changes in FS geometry where fragility fractures are rare. Findings indicate there are declines in bone structure and strength at the NN and IT regions of the proximal femur in older men during hip fracture recovery that far exceed what occurs during normal aging.
•Accelerated bone loss and expansions in bone width at the narrow neck and intertrochanteric in older men after hip fracture•Accompanied by centroid shifts and declines in bending resistance at the proximal femur that exceed changes related to aging•Declines in hip bone structure and strength highlight that more attention is needed in osteoporosis care for older men•Rehabilitation should use bone restoring medications with physical therapy regimens to optimize hip fracture recovery |
| doi_str_mv | 10.1016/j.bone.2019.115187 |
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•Accelerated bone loss and expansions in bone width at the narrow neck and intertrochanteric in older men after hip fracture•Accompanied by centroid shifts and declines in bending resistance at the proximal femur that exceed changes related to aging•Declines in hip bone structure and strength highlight that more attention is needed in osteoporosis care for older men•Rehabilitation should use bone restoring medications with physical therapy regimens to optimize hip fracture recovery</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2019.115187</identifier><identifier>PMID: 31812699</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; DXA ; Fracture prevention ; Injury/fracture healing ; Osteoporosis</subject><ispartof>Bone (New York, N.Y.), 2020-03, Vol.132, p.115187-115187, Article 115187</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c406t-bbde2785febf2bc6d3577bd0c5840ecbd0d55df286e6e4b1f0fac75e59982f9d3</cites><orcidid>0000-0003-3611-5494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bone.2019.115187$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31812699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rathbun, Alan M.</creatorcontrib><creatorcontrib>Magaziner, Jay</creatorcontrib><creatorcontrib>Shardell, Michelle D.</creatorcontrib><creatorcontrib>Beck, Thomas J.</creatorcontrib><creatorcontrib>Yerges-Armstrong, Laura M.</creatorcontrib><creatorcontrib>Orwig, Denise</creatorcontrib><creatorcontrib>Hicks, Gregory E.</creatorcontrib><creatorcontrib>Ryan, Alice S.</creatorcontrib><creatorcontrib>Hochberg, Marc C.</creatorcontrib><title>Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Older men sustain excess bone mineral density (BMD) declines after hip fracture; however, BMD provides no information on mechanical structure and strength. The aim was to assess whether changes in hip bone geometry in older men after hip fracture differ than that expected with aging. Two cohorts were used: Baltimore Hip Studies 7th cohort (BHS-7) and Baltimore Men's Osteoporosis Study (MOST). The sample (N = 170) included older Caucasian men with hip fracture that were propensity score matched (1:1) to community-dwelling non-fractured comparators. Hip Structural Analysis (HSA) calculated aerial BMD and metrics of bone structural strength: cross-sectional bone area (CSA), cortical outer diameter (OD), section modulus (SM), and centroid position (CP). Mixed-effect models estimated changes in HSA parameters and adjusted robust regression models evaluated between-cohort differences in annual percent change at the narrow neck (NN), intertrochanteric (IT), and femoral shaft (FS). Hip fracture was associated with statistically greater declines in NN CSA (β = −2.818; 95% CI: −3.300%, −2.336%), SM (β = −1.896%; 95% CI: −2.711%, −1.080%) and CP (β = −0.884%; 95% CI: −0.889%, −0.880%) and significantly larger increases in NN OD (β = 0.187%; 95% CI: 0.185%, 0.190%). Differences in IT HSA parameters were like the NN but larger in magnitude, while there were favorable changes in FS geometry where fragility fractures are rare. Findings indicate there are declines in bone structure and strength at the NN and IT regions of the proximal femur in older men during hip fracture recovery that far exceed what occurs during normal aging.
•Accelerated bone loss and expansions in bone width at the narrow neck and intertrochanteric in older men after hip fracture•Accompanied by centroid shifts and declines in bending resistance at the proximal femur that exceed changes related to aging•Declines in hip bone structure and strength highlight that more attention is needed in osteoporosis care for older men•Rehabilitation should use bone restoring medications with physical therapy regimens to optimize hip fracture recovery</description><subject>Aging</subject><subject>DXA</subject><subject>Fracture prevention</subject><subject>Injury/fracture healing</subject><subject>Osteoporosis</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU1vVCEUhomxsdPqH3BhWLq5I3CHCzcxJqZabdKkm7omfBxmmMyFEZhp_PdynbbRjQsOJ4f3vBx4EHpLyZISOnzYLk2KsGSEjktKOZXiBVq02HdMDP1LtJCCD13PJDtHF6VsCSH9KOgrdN5TSdkwjgt0_BK8hwzRQsEh4jWkCWoOFpfaquu6wbriugFsU6xZ73SFFvEm7LGB-gAQ8dTWQ2jKueiztvWQAevocEyxeyq45jDtddY15fIanXm9K_Dmcb9EP66_3l99727vvt1cfb7t7IoMtTPGAROSezCeGTu4ngthHLFcrgjYljnOnWdygAFWhnritRUc-DhK5kfXX6JPJ9_9wUzgLPx5g9rnMOn8SyUd1L8nMWzUOh2VIL3ggjaD948GOf08QKlqCsXCbqcjpENRrGdMklWbq0nZSWpzKiWDf76GEjUDU1s1A1MzMHUC1pre_T3gc8sToSb4eBJA-6ZjgKyKDTMuFzLYqlwK__P_Dd6Wq_4</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Rathbun, Alan M.</creator><creator>Magaziner, Jay</creator><creator>Shardell, Michelle D.</creator><creator>Beck, Thomas J.</creator><creator>Yerges-Armstrong, Laura M.</creator><creator>Orwig, Denise</creator><creator>Hicks, Gregory E.</creator><creator>Ryan, Alice S.</creator><creator>Hochberg, Marc C.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3611-5494</orcidid></search><sort><creationdate>20200301</creationdate><title>Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators</title><author>Rathbun, Alan M. ; Magaziner, Jay ; Shardell, Michelle D. ; Beck, Thomas J. ; Yerges-Armstrong, Laura M. ; Orwig, Denise ; Hicks, Gregory E. ; Ryan, Alice S. ; Hochberg, Marc C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-bbde2785febf2bc6d3577bd0c5840ecbd0d55df286e6e4b1f0fac75e59982f9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aging</topic><topic>DXA</topic><topic>Fracture prevention</topic><topic>Injury/fracture healing</topic><topic>Osteoporosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rathbun, Alan M.</creatorcontrib><creatorcontrib>Magaziner, Jay</creatorcontrib><creatorcontrib>Shardell, Michelle D.</creatorcontrib><creatorcontrib>Beck, Thomas J.</creatorcontrib><creatorcontrib>Yerges-Armstrong, Laura M.</creatorcontrib><creatorcontrib>Orwig, Denise</creatorcontrib><creatorcontrib>Hicks, Gregory E.</creatorcontrib><creatorcontrib>Ryan, Alice S.</creatorcontrib><creatorcontrib>Hochberg, Marc C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rathbun, Alan M.</au><au>Magaziner, Jay</au><au>Shardell, Michelle D.</au><au>Beck, Thomas J.</au><au>Yerges-Armstrong, Laura M.</au><au>Orwig, Denise</au><au>Hicks, Gregory E.</au><au>Ryan, Alice S.</au><au>Hochberg, Marc C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>132</volume><spage>115187</spage><epage>115187</epage><pages>115187-115187</pages><artnum>115187</artnum><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Older men sustain excess bone mineral density (BMD) declines after hip fracture; however, BMD provides no information on mechanical structure and strength. The aim was to assess whether changes in hip bone geometry in older men after hip fracture differ than that expected with aging. Two cohorts were used: Baltimore Hip Studies 7th cohort (BHS-7) and Baltimore Men's Osteoporosis Study (MOST). The sample (N = 170) included older Caucasian men with hip fracture that were propensity score matched (1:1) to community-dwelling non-fractured comparators. Hip Structural Analysis (HSA) calculated aerial BMD and metrics of bone structural strength: cross-sectional bone area (CSA), cortical outer diameter (OD), section modulus (SM), and centroid position (CP). Mixed-effect models estimated changes in HSA parameters and adjusted robust regression models evaluated between-cohort differences in annual percent change at the narrow neck (NN), intertrochanteric (IT), and femoral shaft (FS). Hip fracture was associated with statistically greater declines in NN CSA (β = −2.818; 95% CI: −3.300%, −2.336%), SM (β = −1.896%; 95% CI: −2.711%, −1.080%) and CP (β = −0.884%; 95% CI: −0.889%, −0.880%) and significantly larger increases in NN OD (β = 0.187%; 95% CI: 0.185%, 0.190%). Differences in IT HSA parameters were like the NN but larger in magnitude, while there were favorable changes in FS geometry where fragility fractures are rare. Findings indicate there are declines in bone structure and strength at the NN and IT regions of the proximal femur in older men during hip fracture recovery that far exceed what occurs during normal aging.
•Accelerated bone loss and expansions in bone width at the narrow neck and intertrochanteric in older men after hip fracture•Accompanied by centroid shifts and declines in bending resistance at the proximal femur that exceed changes related to aging•Declines in hip bone structure and strength highlight that more attention is needed in osteoporosis care for older men•Rehabilitation should use bone restoring medications with physical therapy regimens to optimize hip fracture recovery</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31812699</pmid><doi>10.1016/j.bone.2019.115187</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3611-5494</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings |
| subjects | Aging DXA Fracture prevention Injury/fracture healing Osteoporosis |
| title | Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators |
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