Human Long Noncoding RNA Interactome: Detection, Characterization and Function

The application of a new generation of sequencing techniques has revealed that most of the genome has already been transcribed. However, only a small part of the genome codes proteins. The rest of the genome "dark matter" belongs to divergent groups of non-coding RNA (ncRNA), that is not t...

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Veröffentlicht in:International journal of molecular sciences 2020-02, Vol.21 (3), p.1027
Hauptverfasser: Kazimierczyk, Marek, Kasprowicz, Marta K, Kasprzyk, Marta E, Wrzesinski, Jan
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container_issue 3
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container_title International journal of molecular sciences
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creator Kazimierczyk, Marek
Kasprowicz, Marta K
Kasprzyk, Marta E
Wrzesinski, Jan
description The application of a new generation of sequencing techniques has revealed that most of the genome has already been transcribed. However, only a small part of the genome codes proteins. The rest of the genome "dark matter" belongs to divergent groups of non-coding RNA (ncRNA), that is not translated into proteins. There are two groups of ncRNAs, which include small and long non-coding RNAs (sncRNA and lncRNA respectively). Over the last decade, there has been an increased interest in lncRNAs and their interaction with cellular components. In this review, we presented the newest information about the human lncRNA interactome. The term lncRNA interactome refers to cellular biomolecules, such as nucleic acids, proteins, and peptides that interact with lncRNA. The lncRNA interactome was characterized in the last decade, however, understanding what role the biomolecules associated with lncRNA play and the nature of these interactions will allow us to better understand lncRNA's biological functions in the cell. We also describe a set of methods currently used for the detection of lncRNA interactome components and the analysis of their interactions. We think that such a holistic and integrated analysis of the lncRNA interactome will help to better understand its potential role in the development of organisms and cancers.
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source MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Biomolecules
Biosynthesis
Cancer
Dark matter
detection lncrna interactome
Gene expression
Genomes
Hypotheses
lncrna
lncrna interactome
lncrna interactome function
long noncoding rna
Medical prognosis
MicroRNAs
Non-coding RNA
Nucleic acids
Peptides
Proteins
Review
RNA polymerase
title Human Long Noncoding RNA Interactome: Detection, Characterization and Function
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