Pathways That Synthesize Phosphatidylethanolamine Impact Candida albicans Hyphal Length and Cell Wall Composition through Transcriptional and Posttranscriptional Mechanisms

is a leading cause of systemic bloodstream infections, and synthesis of the phospholipid phosphatidylethanolamine (PE) is required for virulence. The Δ/Δ Δ/Δ mutant, which cannot synthesize PE by the cytidine diphosphate diacylglycerol (CDP-DAG) pathway, is avirulent in the mouse model of systemic c...

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Veröffentlicht in:	Infection and immunity 2020-02, Vol.88 (3)
Hauptverfasser:	Tams, Robert N, Wagner, Andrew S, Jackson, Joseph W, Gann, Eric R, Sparer, Timothy E, Reynolds, Todd B
Format:	Artikel
Sprache:	eng
Schlagworte:	Candida albicans - metabolism Candida albicans - pathogenicity Candidiasis - microbiology Cell Wall - chemistry Cell Wall - metabolism Chitin - metabolism Fungal and Parasitic Infections Hyphae - cytology Phosphatidylethanolamines - metabolism Transcription, Genetic
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