Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

MutL proteins are ubiquitous and play important roles in DNA metabolism. MutLγ (MLH1–MLH3 heterodimer) is a poorly understood member of the eukaryotic family of MutL proteins that has been implicated in triplet repeat expansion, but its action in this deleterious process has remained unknown. In hum...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-02, Vol.117 (7), p.3535-3542
Hauptverfasser:	Kadyrova, Lyudmila Y., Gujar, Vaibhavi, Burdett, Vickers, Modrich, Paul L., Kadyrov, Farid A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Deoxyribonucleic acid Dimerization DNA DNA Mismatch Repair Downstream effects Endonuclease Endonucleases - chemistry Endonucleases - genetics Endonucleases - metabolism Expansion Humans Metabolism MLH1 protein MSH2 protein MutL Protein Homolog 1 - chemistry MutL Protein Homolog 1 - genetics MutL Protein Homolog 1 - metabolism MutL Proteins - chemistry MutL Proteins - genetics MutL Proteins - metabolism Neurological diseases Proteins Trinucleotide Repeat Expansion
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