High-throughput quantitative microscopy-based half-life measurements of intravenously injected agents

Accurate analysis of blood concentration and circulation half-life is an important consideration for any intravenously administered agent in preclinical development or for therapeutic application. However, the currently available tools to measure these parameters are laborious, expensive, and ineffi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-02, Vol.117 (7), p.3502-3508
Hauptverfasser:	Bracaglia, Laura G., Piotrowski-Daspit, Alexandra S., Lin, Chun-Yu, Moscato, Zoe M., Wang, Yongheng, Tietjen, Gregory T., Saltzman, W. Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Blood Blood circulation Blood levels Blood volume Half-life Microscopy Monoclonal antibodies Nanoparticles Organic chemistry Physical Sciences
Online-Zugang:	Volltext
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