TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle

Trimeric intracellular cation (TRIC)-A and B are distributed to endoplasmic reticulum/sarcoplasmic reticulum intracellular Ca stores. The crystal structure of TRIC has been determined, confirming the homotrimeric structure of a potassium channel. While the pore architectures of TRIC-A and TRIC-B are...

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Veröffentlicht in:	Circulation research 2020-02, Vol.126 (4), p.417-435
Hauptverfasser:	Zhou, Xinyu, Park, Ki Ho, Yamazaki, Daiju, Lin, Pei-hui, Nishi, Miyuki, Ma, Zhiwei, Qiu, Liming, Murayama, Takashi, Zou, Xiaoqin, Takeshima, Hiroshi, Zhou, Jingsong, Ma, Jianjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Signaling Cardiotonic Agents - pharmacology Electrocardiography - drug effects Endoplasmic Reticulum - metabolism Fibrosis - genetics Fibrosis - physiopathology Heart - drug effects Heart - physiopathology HEK293 Cells Humans Ion Channels - chemistry Ion Channels - genetics Ion Channels - metabolism Isoproterenol - pharmacology Mice, Knockout Molecular Docking Simulation Myocardium - cytology Myocardium - metabolism Myocytes, Cardiac - metabolism Protein Binding Ryanodine Receptor Calcium Release Channel - chemistry Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism
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