Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis
The clinical implications of bacteremia among septic patients remain unclear, although a vast amount of data have been accumulated on sepsis. We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter,...
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| Veröffentlicht in: | Scientific reports 2020-02, Vol.10 (1), p.2983, Article 2983 |
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| creator | Komori, Akira Abe, Toshikazu Kushimoto, Shigeki Ogura, Hiroshi Shiraishi, Atsushi Saitoh, Daizoh Fujishima, Seitaro Mayumi, Toshihiko Naito, Toshio Hifumi, Toru Shiino, Yasukazu Nakada, Taka-aki Tarui, Takehiko Otomo, Yasuhiro Okamoto, Kohji Umemura, Yutaka Kotani, Joji Sakamoto, Yuichiro Sasaki, Junichi Shiraishi, Shin-ichiro Takuma, Kiyotsugu Tsuruta, Ryosuke Hagiwara, Akiyoshi Yamakawa, Kazuma Masuno, Tomohiko Takeyama, Naoshi Yamashita, Norio Ikeda, Hiroto Ueyama, Masashi Fujimi, Satoshi Gando, Satoshi |
| description | The clinical implications of bacteremia among septic patients remain unclear, although a vast amount of data have been accumulated on sepsis. We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter, prospective cohort study included 59 intensive care units (ICUs) in Japan between January 2016 and March 2017. The study cohort comprised 1,184 adults (aged ≥ 16 years) who were admitted to an ICU with severe sepsis and diagnosed according to the Sepsis-2 criteria. Of 1,167 patients included in the analysis, 636 (54.5%) had bacteremia. Those with bacteremia had significantly higher rates of septic shock (66.4% vs. 58.9%, p = 0.01) and higher sepsis severity scores, including the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA). No significant difference in in-hospital mortality was seen between patients with and without bacteremia (25.6% vs. 21.0%, p = 0.08). In conclusion, half of severe sepsis patients in ICUs have bacteremia. Although patients with bacteremia had more severe state, between-group differences in patient-centered outcomes, such as in-hospital mortality, have not been fully elucidated. |
| doi_str_mv | 10.1038/s41598-020-59830-6 |
| format | Article |
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We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter, prospective cohort study included 59 intensive care units (ICUs) in Japan between January 2016 and March 2017. The study cohort comprised 1,184 adults (aged ≥ 16 years) who were admitted to an ICU with severe sepsis and diagnosed according to the Sepsis-2 criteria. Of 1,167 patients included in the analysis, 636 (54.5%) had bacteremia. Those with bacteremia had significantly higher rates of septic shock (66.4% vs. 58.9%, p = 0.01) and higher sepsis severity scores, including the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA). No significant difference in in-hospital mortality was seen between patients with and without bacteremia (25.6% vs. 21.0%, p = 0.08). In conclusion, half of severe sepsis patients in ICUs have bacteremia. Although patients with bacteremia had more severe state, between-group differences in patient-centered outcomes, such as in-hospital mortality, have not been fully elucidated.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-59830-6</identifier><identifier>PMID: 32076046</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/699/255/1318 ; Aged ; Aged, 80 and over ; APACHE ; Bacteremia ; Bacteremia - diagnosis ; Bacteremia - epidemiology ; Bacteremia - therapy ; Female ; Hospital Mortality ; Hospitals ; Humanities and Social Sciences ; Humans ; Intensive care ; Intensive care units ; Intensive Care Units - statistics & numerical data ; Length of Stay - statistics & numerical data ; Male ; Middle Aged ; Mortality ; multidisciplinary ; Organ Dysfunction Scores ; Patient Transfer - statistics & numerical data ; Patients ; Prospective Studies ; Respiration, Artificial - statistics & numerical data ; Science ; Science (multidisciplinary) ; Secondary analysis ; Sepsis ; Sepsis - complications ; Sepsis - diagnosis ; Sepsis - mortality ; Sepsis - therapy ; Septic shock ; Shock, Septic - blood ; Shock, Septic - diagnosis ; Shock, Septic - epidemiology ; Shock, Septic - therapy ; Treatment Outcome</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2983, Article 2983</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-cd91cef2f183bb5e63129a0f494c0e897b8a83813a2ab7b259292d51d030cb1f3</citedby><cites>FETCH-LOGICAL-c573t-cd91cef2f183bb5e63129a0f494c0e897b8a83813a2ab7b259292d51d030cb1f3</cites><orcidid>0000-0001-9232-5782 ; 0000-0002-4480-556X ; 0000-0002-9674-1369 ; 0000-0001-8548-3707 ; 0000-0003-2999-4021</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031517/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031517/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27926,27927,41122,42191,51578,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32076046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komori, Akira</creatorcontrib><creatorcontrib>Abe, Toshikazu</creatorcontrib><creatorcontrib>Kushimoto, Shigeki</creatorcontrib><creatorcontrib>Ogura, Hiroshi</creatorcontrib><creatorcontrib>Shiraishi, Atsushi</creatorcontrib><creatorcontrib>Saitoh, Daizoh</creatorcontrib><creatorcontrib>Fujishima, Seitaro</creatorcontrib><creatorcontrib>Mayumi, Toshihiko</creatorcontrib><creatorcontrib>Naito, Toshio</creatorcontrib><creatorcontrib>Hifumi, Toru</creatorcontrib><creatorcontrib>Shiino, Yasukazu</creatorcontrib><creatorcontrib>Nakada, Taka-aki</creatorcontrib><creatorcontrib>Tarui, Takehiko</creatorcontrib><creatorcontrib>Otomo, Yasuhiro</creatorcontrib><creatorcontrib>Okamoto, Kohji</creatorcontrib><creatorcontrib>Umemura, Yutaka</creatorcontrib><creatorcontrib>Kotani, Joji</creatorcontrib><creatorcontrib>Sakamoto, Yuichiro</creatorcontrib><creatorcontrib>Sasaki, Junichi</creatorcontrib><creatorcontrib>Shiraishi, Shin-ichiro</creatorcontrib><creatorcontrib>Takuma, Kiyotsugu</creatorcontrib><creatorcontrib>Tsuruta, Ryosuke</creatorcontrib><creatorcontrib>Hagiwara, Akiyoshi</creatorcontrib><creatorcontrib>Yamakawa, Kazuma</creatorcontrib><creatorcontrib>Masuno, Tomohiko</creatorcontrib><creatorcontrib>Takeyama, Naoshi</creatorcontrib><creatorcontrib>Yamashita, Norio</creatorcontrib><creatorcontrib>Ikeda, Hiroto</creatorcontrib><creatorcontrib>Ueyama, Masashi</creatorcontrib><creatorcontrib>Fujimi, Satoshi</creatorcontrib><creatorcontrib>Gando, Satoshi</creatorcontrib><creatorcontrib>JAAM FORECAST group</creatorcontrib><creatorcontrib>JAAM FORECAST group</creatorcontrib><title>Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The clinical implications of bacteremia among septic patients remain unclear, although a vast amount of data have been accumulated on sepsis. We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter, prospective cohort study included 59 intensive care units (ICUs) in Japan between January 2016 and March 2017. The study cohort comprised 1,184 adults (aged ≥ 16 years) who were admitted to an ICU with severe sepsis and diagnosed according to the Sepsis-2 criteria. Of 1,167 patients included in the analysis, 636 (54.5%) had bacteremia. Those with bacteremia had significantly higher rates of septic shock (66.4% vs. 58.9%, p = 0.01) and higher sepsis severity scores, including the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA). No significant difference in in-hospital mortality was seen between patients with and without bacteremia (25.6% vs. 21.0%, p = 0.08). In conclusion, half of severe sepsis patients in ICUs have bacteremia. 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Daizoh</au><au>Fujishima, Seitaro</au><au>Mayumi, Toshihiko</au><au>Naito, Toshio</au><au>Hifumi, Toru</au><au>Shiino, Yasukazu</au><au>Nakada, Taka-aki</au><au>Tarui, Takehiko</au><au>Otomo, Yasuhiro</au><au>Okamoto, Kohji</au><au>Umemura, Yutaka</au><au>Kotani, Joji</au><au>Sakamoto, Yuichiro</au><au>Sasaki, Junichi</au><au>Shiraishi, Shin-ichiro</au><au>Takuma, Kiyotsugu</au><au>Tsuruta, Ryosuke</au><au>Hagiwara, Akiyoshi</au><au>Yamakawa, Kazuma</au><au>Masuno, Tomohiko</au><au>Takeyama, Naoshi</au><au>Yamashita, Norio</au><au>Ikeda, Hiroto</au><au>Ueyama, Masashi</au><au>Fujimi, Satoshi</au><au>Gando, Satoshi</au><aucorp>JAAM FORECAST group</aucorp><aucorp>JAAM FORECAST group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-02-19</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>2983</spage><pages>2983-</pages><artnum>2983</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The clinical implications of bacteremia among septic patients remain unclear, although a vast amount of data have been accumulated on sepsis. We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter, prospective cohort study included 59 intensive care units (ICUs) in Japan between January 2016 and March 2017. The study cohort comprised 1,184 adults (aged ≥ 16 years) who were admitted to an ICU with severe sepsis and diagnosed according to the Sepsis-2 criteria. Of 1,167 patients included in the analysis, 636 (54.5%) had bacteremia. Those with bacteremia had significantly higher rates of septic shock (66.4% vs. 58.9%, p = 0.01) and higher sepsis severity scores, including the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA). No significant difference in in-hospital mortality was seen between patients with and without bacteremia (25.6% vs. 21.0%, p = 0.08). In conclusion, half of severe sepsis patients in ICUs have bacteremia. Although patients with bacteremia had more severe state, between-group differences in patient-centered outcomes, such as in-hospital mortality, have not been fully elucidated.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32076046</pmid><doi>10.1038/s41598-020-59830-6</doi><orcidid>https://orcid.org/0000-0001-9232-5782</orcidid><orcidid>https://orcid.org/0000-0002-4480-556X</orcidid><orcidid>https://orcid.org/0000-0002-9674-1369</orcidid><orcidid>https://orcid.org/0000-0001-8548-3707</orcidid><orcidid>https://orcid.org/0000-0003-2999-4021</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-02, Vol.10 (1), p.2983, Article 2983 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7031517 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/308/174 692/699/255/1318 Aged Aged, 80 and over APACHE Bacteremia Bacteremia - diagnosis Bacteremia - epidemiology Bacteremia - therapy Female Hospital Mortality Hospitals Humanities and Social Sciences Humans Intensive care Intensive care units Intensive Care Units - statistics & numerical data Length of Stay - statistics & numerical data Male Middle Aged Mortality multidisciplinary Organ Dysfunction Scores Patient Transfer - statistics & numerical data Patients Prospective Studies Respiration, Artificial - statistics & numerical data Science Science (multidisciplinary) Secondary analysis Sepsis Sepsis - complications Sepsis - diagnosis Sepsis - mortality Sepsis - therapy Septic shock Shock, Septic - blood Shock, Septic - diagnosis Shock, Septic - epidemiology Shock, Septic - therapy Treatment Outcome |
| title | Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T12%3A28%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristics%20and%20outcomes%20of%20bacteremia%20among%20ICU-admitted%20patients%20with%20severe%20sepsis&rft.jtitle=Scientific%20reports&rft.au=Komori,%20Akira&rft.aucorp=JAAM%20FORECAST%20group&rft.date=2020-02-19&rft.volume=10&rft.issue=1&rft.spage=2983&rft.pages=2983-&rft.artnum=2983&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-59830-6&rft_dat=%3Cproquest_pubme%3E2358527491%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2358527491&rft_id=info:pmid/32076046&rfr_iscdi=true |