Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy
Altered circulatory asymmetric and symmetric dimethylarginines have been independently reported in patients with end-stage renal failure suggesting their potential role as mediators and early biomarkers of nephropathy. These alterations can also be reflected in urine. Herein, we aimed to evaluate ur...
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| Veröffentlicht in: | Scientific reports 2020-02, Vol.10 (1), p.2970-2970, Article 2970 |
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| creator | Parmar, Dharmeshkumar Bhattacharya, Nivedita Kannan, Shanthini Vadivel, Sangeetha Pandey, Gautam Kumar Ghanate, Avinash Ragi, Nagarjuna Chary Prabu, Paramasivam Pramodkumar, Thyparambil Aravindakshan Manickam, Nagaraj Mohan, Viswanathan Sripadi, Prabhakar Kuppan, Gokulakrishnan Panchagnula, Venkateswarlu |
| description | Altered circulatory asymmetric and symmetric dimethylarginines have been independently reported in patients with end-stage renal failure suggesting their potential role as mediators and early biomarkers of nephropathy. These alterations can also be reflected in urine. Herein, we aimed to evaluate urinary asymmetric to symmetric dimethylarginine ratio (ASR) for early prediction of diabetic nephropathy (DN). In this cross-sectional study, individuals with impaired glucose tolerance (IGT), newly diagnosed diabetes (NDD), diabetic microalbuminuria (MIC), macroalbuminuria (MAC), and normal glucose tolerance (NGT) were recruited from Dr. Mohans’ Diabetes Specialties centre, India. Urinary ASR was measured using a validated high-throughput MALDI-MS/MS method. Significantly lower ASR was observed in MIC (0.909) and MAC (0.741) in comparison to the NGT and NDD groups. On regression models, ASR was associated with MIC [OR: 0.256; 95% CI: 0.158–0.491] and MAC [OR 0.146; 95% CI: 0.071–0.292] controlled for all the available confounding factors. ROC analysis revealed ASR cut-point of 0.95 had C-statistic of 0.691 (95% CI: 0.627-0.755) to discriminate MIC from NDD with 72% sensitivity. Whereas, an ASR cut-point of 0.82 had C-statistic of 0.846 (95% CI: 0.800 - 0.893) had 91% sensitivity for identifying MAC. Our results suggest ASR as a potential early diagnostic biomarker for DN among the Asian Indians. |
| doi_str_mv | 10.1038/s41598-020-59897-1 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7031402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2359398366</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-572cb1c251536c2186773ca79419d3bc472b52ac10beee059d0541b1870534aa3</originalsourceid><addsrcrecordid>eNp9kU9P3DAQxa0KVBDwBXqoInHhkmKP7Ti5VEKIQiUkOMAVy3Fmd40Se2snSHz7Oiz_D_gylub33szoEfKD0V-M8vo4CSabuqRAy1wbVbJvZBeokCVwgK13_x1ykNI9zU9CI1jznexwoKqiFeySu-veTMm1PRadM0sf0uhs8WD6CYuwKKbovImPhUthwJg7nRtwXD32Ji6ddx6LaEYXikWIs77FWe1xvYphbTK3T7YXpk948Fz3yO2fs5vTi_Ly6vzv6cllaYUSYykV2JZZkEzyygKrK6W4NWpet-NthqCVYCyjLSJS2XRUCtayWlHJhTF8j_ze-K6ndsDOoh-j6fU6uiGvr4Nx-mPHu5VehgetKGeCQjY4ejaI4d-EadSDSxb73ngMU9LAZcObmldVRg8_ofdhij6fN1O1BBBCZAo2lI0hpYiL12UY1XOCepOgzgnqpwQ1y6Kf7894lbzklQG-AVJu-SXGt9lf2P4HFTanzQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2358522444</pqid></control><display><type>article</type><title>Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature OA Free Journals</source><creator>Parmar, Dharmeshkumar ; Bhattacharya, Nivedita ; Kannan, Shanthini ; Vadivel, Sangeetha ; Pandey, Gautam Kumar ; Ghanate, Avinash ; Ragi, Nagarjuna Chary ; Prabu, Paramasivam ; Pramodkumar, Thyparambil Aravindakshan ; Manickam, Nagaraj ; Mohan, Viswanathan ; Sripadi, Prabhakar ; Kuppan, Gokulakrishnan ; Panchagnula, Venkateswarlu</creator><creatorcontrib>Parmar, Dharmeshkumar ; Bhattacharya, Nivedita ; Kannan, Shanthini ; Vadivel, Sangeetha ; Pandey, Gautam Kumar ; Ghanate, Avinash ; Ragi, Nagarjuna Chary ; Prabu, Paramasivam ; Pramodkumar, Thyparambil Aravindakshan ; Manickam, Nagaraj ; Mohan, Viswanathan ; Sripadi, Prabhakar ; Kuppan, Gokulakrishnan ; Panchagnula, Venkateswarlu</creatorcontrib><description>Altered circulatory asymmetric and symmetric dimethylarginines have been independently reported in patients with end-stage renal failure suggesting their potential role as mediators and early biomarkers of nephropathy. These alterations can also be reflected in urine. Herein, we aimed to evaluate urinary asymmetric to symmetric dimethylarginine ratio (ASR) for early prediction of diabetic nephropathy (DN). In this cross-sectional study, individuals with impaired glucose tolerance (IGT), newly diagnosed diabetes (NDD), diabetic microalbuminuria (MIC), macroalbuminuria (MAC), and normal glucose tolerance (NGT) were recruited from Dr. Mohans’ Diabetes Specialties centre, India. Urinary ASR was measured using a validated high-throughput MALDI-MS/MS method. Significantly lower ASR was observed in MIC (0.909) and MAC (0.741) in comparison to the NGT and NDD groups. On regression models, ASR was associated with MIC [OR: 0.256; 95% CI: 0.158–0.491] and MAC [OR 0.146; 95% CI: 0.071–0.292] controlled for all the available confounding factors. ROC analysis revealed ASR cut-point of 0.95 had C-statistic of 0.691 (95% CI: 0.627-0.755) to discriminate MIC from NDD with 72% sensitivity. Whereas, an ASR cut-point of 0.82 had C-statistic of 0.846 (95% CI: 0.800 - 0.893) had 91% sensitivity for identifying MAC. Our results suggest ASR as a potential early diagnostic biomarker for DN among the Asian Indians.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-59897-1</identifier><identifier>PMID: 32076062</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2423 ; 692/699/2743/137/138 ; 82/58 ; Adult ; Aged ; Albuminuria - diagnosis ; Albuminuria - etiology ; Albuminuria - urine ; Arginine - analogs & derivatives ; Arginine - urine ; Biomarkers ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - urine ; Diabetic Nephropathies - diagnosis ; Diabetic Nephropathies - etiology ; Diabetic Nephropathies - urine ; Diabetic nephropathy ; End-stage renal disease ; Feasibility Studies ; Female ; Glucose ; Glucose tolerance ; Humanities and Social Sciences ; Humans ; Kidney diseases ; Male ; Middle Aged ; multidisciplinary ; Nephropathy ; Predictive Value of Tests ; Regression analysis ; Renal failure ; ROC Curve ; Science ; Science (multidisciplinary) ; Tandem Mass Spectrometry</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2970-2970, Article 2970</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-572cb1c251536c2186773ca79419d3bc472b52ac10beee059d0541b1870534aa3</citedby><cites>FETCH-LOGICAL-c474t-572cb1c251536c2186773ca79419d3bc472b52ac10beee059d0541b1870534aa3</cites><orcidid>0000-0002-8626-1601</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031402/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031402/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32076062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parmar, Dharmeshkumar</creatorcontrib><creatorcontrib>Bhattacharya, Nivedita</creatorcontrib><creatorcontrib>Kannan, Shanthini</creatorcontrib><creatorcontrib>Vadivel, Sangeetha</creatorcontrib><creatorcontrib>Pandey, Gautam Kumar</creatorcontrib><creatorcontrib>Ghanate, Avinash</creatorcontrib><creatorcontrib>Ragi, Nagarjuna Chary</creatorcontrib><creatorcontrib>Prabu, Paramasivam</creatorcontrib><creatorcontrib>Pramodkumar, Thyparambil Aravindakshan</creatorcontrib><creatorcontrib>Manickam, Nagaraj</creatorcontrib><creatorcontrib>Mohan, Viswanathan</creatorcontrib><creatorcontrib>Sripadi, Prabhakar</creatorcontrib><creatorcontrib>Kuppan, Gokulakrishnan</creatorcontrib><creatorcontrib>Panchagnula, Venkateswarlu</creatorcontrib><title>Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Altered circulatory asymmetric and symmetric dimethylarginines have been independently reported in patients with end-stage renal failure suggesting their potential role as mediators and early biomarkers of nephropathy. These alterations can also be reflected in urine. Herein, we aimed to evaluate urinary asymmetric to symmetric dimethylarginine ratio (ASR) for early prediction of diabetic nephropathy (DN). In this cross-sectional study, individuals with impaired glucose tolerance (IGT), newly diagnosed diabetes (NDD), diabetic microalbuminuria (MIC), macroalbuminuria (MAC), and normal glucose tolerance (NGT) were recruited from Dr. Mohans’ Diabetes Specialties centre, India. Urinary ASR was measured using a validated high-throughput MALDI-MS/MS method. Significantly lower ASR was observed in MIC (0.909) and MAC (0.741) in comparison to the NGT and NDD groups. On regression models, ASR was associated with MIC [OR: 0.256; 95% CI: 0.158–0.491] and MAC [OR 0.146; 95% CI: 0.071–0.292] controlled for all the available confounding factors. ROC analysis revealed ASR cut-point of 0.95 had C-statistic of 0.691 (95% CI: 0.627-0.755) to discriminate MIC from NDD with 72% sensitivity. Whereas, an ASR cut-point of 0.82 had C-statistic of 0.846 (95% CI: 0.800 - 0.893) had 91% sensitivity for identifying MAC. Our results suggest ASR as a potential early diagnostic biomarker for DN among the Asian Indians.</description><subject>692/53/2423</subject><subject>692/699/2743/137/138</subject><subject>82/58</subject><subject>Adult</subject><subject>Aged</subject><subject>Albuminuria - diagnosis</subject><subject>Albuminuria - etiology</subject><subject>Albuminuria - urine</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - urine</subject><subject>Biomarkers</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - urine</subject><subject>Diabetic Nephropathies - diagnosis</subject><subject>Diabetic Nephropathies - etiology</subject><subject>Diabetic Nephropathies - urine</subject><subject>Diabetic nephropathy</subject><subject>End-stage renal disease</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Nephropathy</subject><subject>Predictive Value of Tests</subject><subject>Regression analysis</subject><subject>Renal failure</subject><subject>ROC Curve</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Tandem Mass Spectrometry</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9P3DAQxa0KVBDwBXqoInHhkmKP7Ti5VEKIQiUkOMAVy3Fmd40Se2snSHz7Oiz_D_gylub33szoEfKD0V-M8vo4CSabuqRAy1wbVbJvZBeokCVwgK13_x1ykNI9zU9CI1jznexwoKqiFeySu-veTMm1PRadM0sf0uhs8WD6CYuwKKbovImPhUthwJg7nRtwXD32Ji6ddx6LaEYXikWIs77FWe1xvYphbTK3T7YXpk948Fz3yO2fs5vTi_Ly6vzv6cllaYUSYykV2JZZkEzyygKrK6W4NWpet-NthqCVYCyjLSJS2XRUCtayWlHJhTF8j_ze-K6ndsDOoh-j6fU6uiGvr4Nx-mPHu5VehgetKGeCQjY4ejaI4d-EadSDSxb73ngMU9LAZcObmldVRg8_ofdhij6fN1O1BBBCZAo2lI0hpYiL12UY1XOCepOgzgnqpwQ1y6Kf7894lbzklQG-AVJu-SXGt9lf2P4HFTanzQ</recordid><startdate>20200219</startdate><enddate>20200219</enddate><creator>Parmar, Dharmeshkumar</creator><creator>Bhattacharya, Nivedita</creator><creator>Kannan, Shanthini</creator><creator>Vadivel, Sangeetha</creator><creator>Pandey, Gautam Kumar</creator><creator>Ghanate, Avinash</creator><creator>Ragi, Nagarjuna Chary</creator><creator>Prabu, Paramasivam</creator><creator>Pramodkumar, Thyparambil Aravindakshan</creator><creator>Manickam, Nagaraj</creator><creator>Mohan, Viswanathan</creator><creator>Sripadi, Prabhakar</creator><creator>Kuppan, Gokulakrishnan</creator><creator>Panchagnula, Venkateswarlu</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8626-1601</orcidid></search><sort><creationdate>20200219</creationdate><title>Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy</title><author>Parmar, Dharmeshkumar ; Bhattacharya, Nivedita ; Kannan, Shanthini ; Vadivel, Sangeetha ; Pandey, Gautam Kumar ; Ghanate, Avinash ; Ragi, Nagarjuna Chary ; Prabu, Paramasivam ; Pramodkumar, Thyparambil Aravindakshan ; Manickam, Nagaraj ; Mohan, Viswanathan ; Sripadi, Prabhakar ; Kuppan, Gokulakrishnan ; Panchagnula, Venkateswarlu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-572cb1c251536c2186773ca79419d3bc472b52ac10beee059d0541b1870534aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/53/2423</topic><topic>692/699/2743/137/138</topic><topic>82/58</topic><topic>Adult</topic><topic>Aged</topic><topic>Albuminuria - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parmar, Dharmeshkumar</au><au>Bhattacharya, Nivedita</au><au>Kannan, Shanthini</au><au>Vadivel, Sangeetha</au><au>Pandey, Gautam Kumar</au><au>Ghanate, Avinash</au><au>Ragi, Nagarjuna Chary</au><au>Prabu, Paramasivam</au><au>Pramodkumar, Thyparambil Aravindakshan</au><au>Manickam, Nagaraj</au><au>Mohan, Viswanathan</au><au>Sripadi, Prabhakar</au><au>Kuppan, Gokulakrishnan</au><au>Panchagnula, Venkateswarlu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-02-19</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>2970</spage><epage>2970</epage><pages>2970-2970</pages><artnum>2970</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Altered circulatory asymmetric and symmetric dimethylarginines have been independently reported in patients with end-stage renal failure suggesting their potential role as mediators and early biomarkers of nephropathy. These alterations can also be reflected in urine. Herein, we aimed to evaluate urinary asymmetric to symmetric dimethylarginine ratio (ASR) for early prediction of diabetic nephropathy (DN). In this cross-sectional study, individuals with impaired glucose tolerance (IGT), newly diagnosed diabetes (NDD), diabetic microalbuminuria (MIC), macroalbuminuria (MAC), and normal glucose tolerance (NGT) were recruited from Dr. Mohans’ Diabetes Specialties centre, India. Urinary ASR was measured using a validated high-throughput MALDI-MS/MS method. Significantly lower ASR was observed in MIC (0.909) and MAC (0.741) in comparison to the NGT and NDD groups. On regression models, ASR was associated with MIC [OR: 0.256; 95% CI: 0.158–0.491] and MAC [OR 0.146; 95% CI: 0.071–0.292] controlled for all the available confounding factors. ROC analysis revealed ASR cut-point of 0.95 had C-statistic of 0.691 (95% CI: 0.627-0.755) to discriminate MIC from NDD with 72% sensitivity. Whereas, an ASR cut-point of 0.82 had C-statistic of 0.846 (95% CI: 0.800 - 0.893) had 91% sensitivity for identifying MAC. Our results suggest ASR as a potential early diagnostic biomarker for DN among the Asian Indians.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32076062</pmid><doi>10.1038/s41598-020-59897-1</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-8626-1601</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/53/2423 692/699/2743/137/138 82/58 Adult Aged Albuminuria - diagnosis Albuminuria - etiology Albuminuria - urine Arginine - analogs & derivatives Arginine - urine Biomarkers Chromatography, High Pressure Liquid Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - urine Diabetic Nephropathies - diagnosis Diabetic Nephropathies - etiology Diabetic Nephropathies - urine Diabetic nephropathy End-stage renal disease Feasibility Studies Female Glucose Glucose tolerance Humanities and Social Sciences Humans Kidney diseases Male Middle Aged multidisciplinary Nephropathy Predictive Value of Tests Regression analysis Renal failure ROC Curve Science Science (multidisciplinary) Tandem Mass Spectrometry |
| title | Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy |
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