A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte

Mechanical forces are transduced to nuclear responses via the linkers of the nucleoskeleton and cytoskeleton (LINC) complex, which couples the cytoskeleton to the nuclear lamina and associated chromatin. While disruption of the LINC complex can cause cardiomyopathy, the relevant interactions that br...

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Veröffentlicht in:	Circulation research 2020-01, Vol.126 (3), p.e10-e26
Hauptverfasser:	Heffler, Julie, Shah, Parisha P., Robison, Patrick, Phyo, Sai, Veliz, Kimberly, Uchida, Keita, Bogush, Alexey, Rhoades, Joshua, Jain, Rajan, Prosser, Benjamin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Actin Cytoskeleton - ultrastructure Animals Cells, Cultured Desmin - genetics Desmin - metabolism Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Microtubules - metabolism Microtubules - ultrastructure Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Nuclear Matrix - metabolism Nuclear Matrix - ultrastructure Nuclear Proteins - genetics Nuclear Proteins - metabolism Rats Rats, Sprague-Dawley
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