Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model
The current study aimed to formulate Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) complex. The nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (CTAB)-based hydrogel (CCH) that entrapped mupirocin (M) and selenium nanoparticles (SeNPs). The in vitro studies were performed by...
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| description | The current study aimed to formulate Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) complex. The nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (CTAB)-based hydrogel (CCH) that entrapped mupirocin (M) and selenium nanoparticles (SeNPs). The
in vitro
studies were performed by evaluation of the antibacterial activity and toxicity on L929 mouse fibroblast cell line. The
in vivo
study was conducted on rat diabetic wound infection model that was infected by mupirocin-methicillin-resistant
Staphylococcus aureus
(MMRSA). The wounds were treated by M-SeNPs-CCH nanohybrid system with concentrations of M; 20 mg/ml, CCH; 2 mg/ml and SeNPs; 512 μg/ml in two times/day for 21 days. The therapeutic effect of this nanohybrid system was evaluated by monitoring wound contraction and histopathological changes. Evaluation of the average wound healing time showed a significant difference between the treatment and control groups (
P
≤0.05). The histopathological study indicated that the amount of wound healing was considerable in M-SeNPs-CCH nanohybrid system groups compared to the control and M groups. The M-SeNPs-CCH nanohybrid system formulated in this study was able to reduce 3-fold MIC of mupirocin with synergistic antibacterial activity as well as to play a significant role in wound contraction, angiogenesis, fibroblastosis, collagenesis, proliferation of hair follicle, and epidermis growth compared to the control group (
P
≤ 0.05). This research suggests that this nanohybrid system might be a development for the treatment of diabetic wound infection at mild stage. |
| doi_str_mv | 10.1038/s41598-020-59510-5 |
| format | Article |
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in vitro
studies were performed by evaluation of the antibacterial activity and toxicity on L929 mouse fibroblast cell line. The
in vivo
study was conducted on rat diabetic wound infection model that was infected by mupirocin-methicillin-resistant
Staphylococcus aureus
(MMRSA). The wounds were treated by M-SeNPs-CCH nanohybrid system with concentrations of M; 20 mg/ml, CCH; 2 mg/ml and SeNPs; 512 μg/ml in two times/day for 21 days. The therapeutic effect of this nanohybrid system was evaluated by monitoring wound contraction and histopathological changes. Evaluation of the average wound healing time showed a significant difference between the treatment and control groups (
P
≤0.05). The histopathological study indicated that the amount of wound healing was considerable in M-SeNPs-CCH nanohybrid system groups compared to the control and M groups. The M-SeNPs-CCH nanohybrid system formulated in this study was able to reduce 3-fold MIC of mupirocin with synergistic antibacterial activity as well as to play a significant role in wound contraction, angiogenesis, fibroblastosis, collagenesis, proliferation of hair follicle, and epidermis growth compared to the control group (
P
≤ 0.05). This research suggests that this nanohybrid system might be a development for the treatment of diabetic wound infection at mild stage.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-59510-5</identifier><identifier>PMID: 32071320</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326 ; 631/80 ; 692/308 ; 692/420 ; 692/699 ; Angiogenesis ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Chitosan ; Chitosan - chemistry ; Chitosan - pharmacology ; Collagen ; Contraction ; Diabetes ; Diabetes Complications - drug therapy ; Diabetes Complications - microbiology ; Diabetes Complications - pathology ; Diabetes mellitus ; Disease Models, Animal ; Drug resistance ; Drug Synergism ; Epidermis ; Humanities and Social Sciences ; Humans ; Hydrogels ; Methicillin ; Minimum inhibitory concentration ; multidisciplinary ; Mupirocin ; Mupirocin - chemistry ; Mupirocin - pharmacology ; Nanoparticles ; Nanostructures - chemistry ; Rats ; Science ; Science (multidisciplinary) ; Selenium ; Selenium - chemistry ; Selenium - pharmacology ; Staphylococcus aureus ; Staphylococcus infections ; Toxicity ; Wound healing ; Wound Healing - drug effects ; Wound infection ; Wound Infection - drug therapy ; Wound Infection - microbiology ; Wound Infection - pathology</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2854, Article 2854</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-64c7b1503761c1b74a0abed14f8263df3adc7ae2abed674c278893de7180c3a23</citedby><cites>FETCH-LOGICAL-c474t-64c7b1503761c1b74a0abed14f8263df3adc7ae2abed674c278893de7180c3a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028993/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028993/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32071320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golmohammadi, Reza</creatorcontrib><creatorcontrib>Najar-Peerayeh, Shahin</creatorcontrib><creatorcontrib>Tohidi Moghadam, Tahereh</creatorcontrib><creatorcontrib>Hosseini, Seyed Mohammad Javad</creatorcontrib><title>Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The current study aimed to formulate Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) complex. The nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (CTAB)-based hydrogel (CCH) that entrapped mupirocin (M) and selenium nanoparticles (SeNPs). The
in vitro
studies were performed by evaluation of the antibacterial activity and toxicity on L929 mouse fibroblast cell line. The
in vivo
study was conducted on rat diabetic wound infection model that was infected by mupirocin-methicillin-resistant
Staphylococcus aureus
(MMRSA). The wounds were treated by M-SeNPs-CCH nanohybrid system with concentrations of M; 20 mg/ml, CCH; 2 mg/ml and SeNPs; 512 μg/ml in two times/day for 21 days. The therapeutic effect of this nanohybrid system was evaluated by monitoring wound contraction and histopathological changes. Evaluation of the average wound healing time showed a significant difference between the treatment and control groups (
P
≤0.05). The histopathological study indicated that the amount of wound healing was considerable in M-SeNPs-CCH nanohybrid system groups compared to the control and M groups. The M-SeNPs-CCH nanohybrid system formulated in this study was able to reduce 3-fold MIC of mupirocin with synergistic antibacterial activity as well as to play a significant role in wound contraction, angiogenesis, fibroblastosis, collagenesis, proliferation of hair follicle, and epidermis growth compared to the control group (
P
≤ 0.05). This research suggests that this nanohybrid system might be a development for the treatment of diabetic wound infection at mild stage.</description><subject>631/326</subject><subject>631/80</subject><subject>692/308</subject><subject>692/420</subject><subject>692/699</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - pharmacology</subject><subject>Collagen</subject><subject>Contraction</subject><subject>Diabetes</subject><subject>Diabetes Complications - drug therapy</subject><subject>Diabetes Complications - microbiology</subject><subject>Diabetes Complications - pathology</subject><subject>Diabetes mellitus</subject><subject>Disease Models, Animal</subject><subject>Drug resistance</subject><subject>Drug Synergism</subject><subject>Epidermis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Methicillin</subject><subject>Minimum inhibitory concentration</subject><subject>multidisciplinary</subject><subject>Mupirocin</subject><subject>Mupirocin - chemistry</subject><subject>Mupirocin - pharmacology</subject><subject>Nanoparticles</subject><subject>Nanostructures - chemistry</subject><subject>Rats</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Selenium</subject><subject>Selenium - chemistry</subject><subject>Selenium - pharmacology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Toxicity</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wound infection</subject><subject>Wound Infection - drug therapy</subject><subject>Wound Infection - microbiology</subject><subject>Wound Infection - pathology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9Uctu1DAUtRCIVqU_wAJZYh3wK-OEBdJoeLRSC4jwWFqOczPjKmMH2xkpP8e34SGllA1e3Hvle-45RzoIPaXkBSW8ehkFLeuqIIwUZV3SXB-gU0ZEWTDO2MN78wk6j_GG5FeyWtD6MTrhjEiayyn62cwOwtbGZA1eu2RbbRIEqwe8NskebJqxdh3-7qdcL0AP1m3xp-BHCMlCxL7HDQzg7LQvNjubfNSuuJ5GG7yxDn_Qzu_mNtgON3NMsH-VVXBefLMHj5s0dTP2Dn_WCb-xuoWjjSbpcTcP3nhjpoj1FCC3xcGl6yH7yifXvoPhCXrU6yHC-W0_Q1_fvf2yuSiuPr6_3KyvCiOkSMVKGNnSknC5ooa2UmiStToq-oqteNdz3RmpgR0_V1IYJquq5h1IWhHDNeNn6PXCO07tHjoDLgU9qDHYvQ6z8tqqfzfO7tTWH5QkrKprngme3xIE_2OCmNSNn4LLnhXjpRRUEFplFFtQJvgYA_R3CpSoY-xqiV3l2NXv2FWZj57d93Z38ifkDOALIOaV20L4q_0f2l_Lzb2Z</recordid><startdate>20200218</startdate><enddate>20200218</enddate><creator>Golmohammadi, Reza</creator><creator>Najar-Peerayeh, Shahin</creator><creator>Tohidi Moghadam, Tahereh</creator><creator>Hosseini, Seyed Mohammad Javad</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20200218</creationdate><title>Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model</title><author>Golmohammadi, Reza ; Najar-Peerayeh, Shahin ; Tohidi Moghadam, Tahereh ; Hosseini, Seyed Mohammad Javad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-64c7b1503761c1b74a0abed14f8263df3adc7ae2abed674c278893de7180c3a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/326</topic><topic>631/80</topic><topic>692/308</topic><topic>692/420</topic><topic>692/699</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Chitosan</topic><topic>Chitosan - chemistry</topic><topic>Chitosan - pharmacology</topic><topic>Collagen</topic><topic>Contraction</topic><topic>Diabetes</topic><topic>Diabetes Complications - drug therapy</topic><topic>Diabetes Complications - microbiology</topic><topic>Diabetes Complications - pathology</topic><topic>Diabetes mellitus</topic><topic>Disease Models, Animal</topic><topic>Drug resistance</topic><topic>Drug Synergism</topic><topic>Epidermis</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hydrogels</topic><topic>Methicillin</topic><topic>Minimum inhibitory concentration</topic><topic>multidisciplinary</topic><topic>Mupirocin</topic><topic>Mupirocin - chemistry</topic><topic>Mupirocin - pharmacology</topic><topic>Nanoparticles</topic><topic>Nanostructures - chemistry</topic><topic>Rats</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Selenium</topic><topic>Selenium - chemistry</topic><topic>Selenium - pharmacology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Toxicity</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wound infection</topic><topic>Wound Infection - drug therapy</topic><topic>Wound Infection - microbiology</topic><topic>Wound Infection - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Golmohammadi, Reza</creatorcontrib><creatorcontrib>Najar-Peerayeh, Shahin</creatorcontrib><creatorcontrib>Tohidi Moghadam, Tahereh</creatorcontrib><creatorcontrib>Hosseini, Seyed Mohammad Javad</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golmohammadi, Reza</au><au>Najar-Peerayeh, Shahin</au><au>Tohidi Moghadam, Tahereh</au><au>Hosseini, Seyed Mohammad Javad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-02-18</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>2854</spage><pages>2854-</pages><artnum>2854</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The current study aimed to formulate Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) complex. The nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (CTAB)-based hydrogel (CCH) that entrapped mupirocin (M) and selenium nanoparticles (SeNPs). The
in vitro
studies were performed by evaluation of the antibacterial activity and toxicity on L929 mouse fibroblast cell line. The
in vivo
study was conducted on rat diabetic wound infection model that was infected by mupirocin-methicillin-resistant
Staphylococcus aureus
(MMRSA). The wounds were treated by M-SeNPs-CCH nanohybrid system with concentrations of M; 20 mg/ml, CCH; 2 mg/ml and SeNPs; 512 μg/ml in two times/day for 21 days. The therapeutic effect of this nanohybrid system was evaluated by monitoring wound contraction and histopathological changes. Evaluation of the average wound healing time showed a significant difference between the treatment and control groups (
P
≤0.05). The histopathological study indicated that the amount of wound healing was considerable in M-SeNPs-CCH nanohybrid system groups compared to the control and M groups. The M-SeNPs-CCH nanohybrid system formulated in this study was able to reduce 3-fold MIC of mupirocin with synergistic antibacterial activity as well as to play a significant role in wound contraction, angiogenesis, fibroblastosis, collagenesis, proliferation of hair follicle, and epidermis growth compared to the control group (
P
≤ 0.05). This research suggests that this nanohybrid system might be a development for the treatment of diabetic wound infection at mild stage.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32071320</pmid><doi>10.1038/s41598-020-59510-5</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 631/326 631/80 692/308 692/420 692/699 Angiogenesis Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Chitosan Chitosan - chemistry Chitosan - pharmacology Collagen Contraction Diabetes Diabetes Complications - drug therapy Diabetes Complications - microbiology Diabetes Complications - pathology Diabetes mellitus Disease Models, Animal Drug resistance Drug Synergism Epidermis Humanities and Social Sciences Humans Hydrogels Methicillin Minimum inhibitory concentration multidisciplinary Mupirocin Mupirocin - chemistry Mupirocin - pharmacology Nanoparticles Nanostructures - chemistry Rats Science Science (multidisciplinary) Selenium Selenium - chemistry Selenium - pharmacology Staphylococcus aureus Staphylococcus infections Toxicity Wound healing Wound Healing - drug effects Wound infection Wound Infection - drug therapy Wound Infection - microbiology Wound Infection - pathology |
| title | Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model |
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