Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo

Worldwide, lung cancer remains a leading cause of cancer mortality. Bruceine D (BD) has been shown to induce pancreatic cancer cell death via several different mechanisms. In this study, we demonstrated that BD inhibited lung cancer cell proliferation. Apoptosis and autophagy were the most important...

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Veröffentlicht in:	Cell death & disease 2020-02, Vol.11 (2), p.126-126, Article 126
Hauptverfasser:	Fan, Jiangjiang, Ren, Dongmei, Wang, Jinxia, Liu, Xiaoqing, Zhang, Huaran, Wu, Mingsheng, Yang, Guotao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/31 14/19 14/28 14/34 14/35 14/63 631/154/570 631/67/1612/1350 631/80/39 64/60 82/80 A549 Cells Acetylcysteine Animals Antibodies Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biochemistry Biomedical and Life Sciences Cell activation Cell Biology Cell Culture Cell death Cell growth Cell proliferation Cell Proliferation - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Female Humans Immunology JNK Mitogen-Activated Protein Kinases - metabolism Life Sciences Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - pathology MAP kinase MAP Kinase Signaling System - drug effects Mice, Inbred BALB C Mice, Nude Pancreatic cancer Phagocytosis Phosphorylation Quassins - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Toxicity Tumor Burden - drug effects Xenograft Model Antitumor Assays Xenografts
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