An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018
Aim and background Colon and rectum (colorectal) cancer cause substantial mortality and morbidity worldwide. The management and control of a complex disease such as cancer cannot rely on the old strategy of “one disease one medicine” and must make a transition into new-age practices involving predic...
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| description | Aim and background
Colon and rectum (colorectal) cancer cause substantial mortality and morbidity worldwide. The management and control of a complex disease such as cancer cannot rely on the old strategy of “one disease one medicine” and must make a transition into new-age practices involving predictive, preventive, and personalized medicine (PPPM) at its core. Adoption of PPPM approach to cancer management at the policy level requires quantification of cancer burden at the country level. For this purpose, we examine the burden of colorectal cancer in 185 countries in 2018. Based on results, we discuss the opportunities presented by PPPM and challenges to be encountered while adopting PPPM for the treatment and prevention of colorectal cancer.
Data and methods
Age- and sex-wise estimates of colorectal cancer were procured from the GLOBOCAN 2018. The country- and region-wise burden of colorectal cancer in 185 countries was examined using all-age and age-standardized incidence and mortality estimates. Human development index (HDI) was employed as the indicator of socioeconomic status of a country. Mortality-to-incidence ratio (MIR) was employed as the proxy of 5-year survival rate.
Results
Globally, colorectal cancer claimed an estimated 880,792 lives (males 484,224; females 396,568) with 1.85 million new cases (males 1.03 million; females 823,303) were estimated to be diagnosed in 2018. Globally, the age-standardized incidence rate (ASIR) was 19.7/100,000, whereas age-standardized mortality rate (ASMR) recorded to be 16.3/100,000 in 2018. Age-standardized rates were the highest in developed countries led by Hungary with ASIR of 51.2/100,000 followed by South Korea with ASIR of 44.5/100,000. ASMR followed the patterns of ASIR with the highest ASMR recorded by Hungary (21.5 per 100,000) and Slovakia (20.4 per 100,000). Globally, MIR stood at 0.48, and among the countries recording more than 1000 cases, Nepal registered the highest MIR of 0.83 and the lowest was recorded by South Korea (0.27). The age-standardized rates exhibited nonlinear association with HDI, whereas MIR was negatively associated with HDI.
Conclusion
Colorectal cancer causes a substantial burden worldwide and exhibit a positive association with the socioeconomic status. With the aid of improving screening modalities, preventable nature of the disease (due to dietary and lifestyle risk factors) and improving treatment procedures, the burden of CRC can largely be curtailed. The high burden of |
| doi_str_mv | 10.1007/s13167-019-00185-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7028897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A600224962</galeid><sourcerecordid>A600224962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c607t-5ad068a653e6efad671d4d3be9219f65a44591ce6b095b20623c670764dea8583</originalsourceid><addsrcrecordid>eNp9Uk1v1DAUtCpQWy39AxyQJS5cUvwRf4QD0nYFBWnVvcDZcpyXxVViFzup2H-P2y1bilDtg5_8ZuZpngah15ScU0LU-0w5laoitKkIoVpUuyN0SrXSlSBavDjUSp2gs5yvSTmc6UI9Riec0bqQ9Ckyy4Dhlx19sJOPAcceuzjEBG6yA3Y2OEi4nVMHAbc7nKPzEVwMcfQO58lOc_6A4daXvgPcpzjiy_XmYrNaXmFWRrxCL3s7ZDh7eBfo--dP31ZfqvXm8utqua6cJGqqhO2I1FYKDhJ620lFu7rjLTSMNr0Utq5FQx3IljSiZUQy7qQiStYdWC00X6CPe92buR2hcxCmZAdzk_xo085E683TTvA_zDbeGkWY1o0qAu8eBFL8OUOezOizg2GwAeKcDeOq5lTX99C3_0Cv45xCsVdQQgkqBOGPqK0dwPjQxzLX3YmapSSEsbopLhbo_D-ocjsoG44Bel_-nxDYnuBSzDlBf_BIiblLhtknw5RkmPtkmF0hvfl7OwfKnxwUAN8DcmmFLaRHS8_I_ga5yMG8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2357515503</pqid></control><display><type>article</type><title>An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018</title><source>SpringerLink Journals</source><source>PubMed Central</source><creator>Sharma, Rajesh</creator><creatorcontrib>Sharma, Rajesh</creatorcontrib><description>Aim and background
Colon and rectum (colorectal) cancer cause substantial mortality and morbidity worldwide. The management and control of a complex disease such as cancer cannot rely on the old strategy of “one disease one medicine” and must make a transition into new-age practices involving predictive, preventive, and personalized medicine (PPPM) at its core. Adoption of PPPM approach to cancer management at the policy level requires quantification of cancer burden at the country level. For this purpose, we examine the burden of colorectal cancer in 185 countries in 2018. Based on results, we discuss the opportunities presented by PPPM and challenges to be encountered while adopting PPPM for the treatment and prevention of colorectal cancer.
Data and methods
Age- and sex-wise estimates of colorectal cancer were procured from the GLOBOCAN 2018. The country- and region-wise burden of colorectal cancer in 185 countries was examined using all-age and age-standardized incidence and mortality estimates. Human development index (HDI) was employed as the indicator of socioeconomic status of a country. Mortality-to-incidence ratio (MIR) was employed as the proxy of 5-year survival rate.
Results
Globally, colorectal cancer claimed an estimated 880,792 lives (males 484,224; females 396,568) with 1.85 million new cases (males 1.03 million; females 823,303) were estimated to be diagnosed in 2018. Globally, the age-standardized incidence rate (ASIR) was 19.7/100,000, whereas age-standardized mortality rate (ASMR) recorded to be 16.3/100,000 in 2018. Age-standardized rates were the highest in developed countries led by Hungary with ASIR of 51.2/100,000 followed by South Korea with ASIR of 44.5/100,000. ASMR followed the patterns of ASIR with the highest ASMR recorded by Hungary (21.5 per 100,000) and Slovakia (20.4 per 100,000). Globally, MIR stood at 0.48, and among the countries recording more than 1000 cases, Nepal registered the highest MIR of 0.83 and the lowest was recorded by South Korea (0.27). The age-standardized rates exhibited nonlinear association with HDI, whereas MIR was negatively associated with HDI.
Conclusion
Colorectal cancer causes a substantial burden worldwide and exhibit a positive association with the socioeconomic status. With the aid of improving screening modalities, preventable nature of the disease (due to dietary and lifestyle risk factors) and improving treatment procedures, the burden of CRC can largely be curtailed. The high burden of CRC in developing countries, therefore, calls for effective prevention strategies, cost-effective screening, and early-stage detection, cost-effective predictive, and personalized treatment regime.</description><identifier>ISSN: 1878-5077</identifier><identifier>EISSN: 1878-5085</identifier><identifier>DOI: 10.1007/s13167-019-00185-y</identifier><identifier>PMID: 32140188</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age ; Analysis ; Biomedical and Life Sciences ; Biomedicine ; Care and treatment ; Colorectal cancer ; Developing countries ; Human development ; Industrialized countries ; Medical research ; Medicine/Public Health ; Morbidity ; Mortality ; Prevention ; Proxy ; Social class ; Socioeconomic factors ; Socioeconomic status</subject><ispartof>The EPMA journal, 2020-03, Vol.11 (1), p.95-117</ispartof><rights>European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2019</rights><rights>European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2019.</rights><rights>COPYRIGHT 2019 BioMed Central Ltd.</rights><rights>2019© European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-5ad068a653e6efad671d4d3be9219f65a44591ce6b095b20623c670764dea8583</citedby><cites>FETCH-LOGICAL-c607t-5ad068a653e6efad671d4d3be9219f65a44591ce6b095b20623c670764dea8583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028897/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028897/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32140188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Rajesh</creatorcontrib><title>An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018</title><title>The EPMA journal</title><addtitle>EPMA Journal</addtitle><addtitle>EPMA J</addtitle><description>Aim and background
Colon and rectum (colorectal) cancer cause substantial mortality and morbidity worldwide. The management and control of a complex disease such as cancer cannot rely on the old strategy of “one disease one medicine” and must make a transition into new-age practices involving predictive, preventive, and personalized medicine (PPPM) at its core. Adoption of PPPM approach to cancer management at the policy level requires quantification of cancer burden at the country level. For this purpose, we examine the burden of colorectal cancer in 185 countries in 2018. Based on results, we discuss the opportunities presented by PPPM and challenges to be encountered while adopting PPPM for the treatment and prevention of colorectal cancer.
Data and methods
Age- and sex-wise estimates of colorectal cancer were procured from the GLOBOCAN 2018. The country- and region-wise burden of colorectal cancer in 185 countries was examined using all-age and age-standardized incidence and mortality estimates. Human development index (HDI) was employed as the indicator of socioeconomic status of a country. Mortality-to-incidence ratio (MIR) was employed as the proxy of 5-year survival rate.
Results
Globally, colorectal cancer claimed an estimated 880,792 lives (males 484,224; females 396,568) with 1.85 million new cases (males 1.03 million; females 823,303) were estimated to be diagnosed in 2018. Globally, the age-standardized incidence rate (ASIR) was 19.7/100,000, whereas age-standardized mortality rate (ASMR) recorded to be 16.3/100,000 in 2018. Age-standardized rates were the highest in developed countries led by Hungary with ASIR of 51.2/100,000 followed by South Korea with ASIR of 44.5/100,000. ASMR followed the patterns of ASIR with the highest ASMR recorded by Hungary (21.5 per 100,000) and Slovakia (20.4 per 100,000). Globally, MIR stood at 0.48, and among the countries recording more than 1000 cases, Nepal registered the highest MIR of 0.83 and the lowest was recorded by South Korea (0.27). The age-standardized rates exhibited nonlinear association with HDI, whereas MIR was negatively associated with HDI.
Conclusion
Colorectal cancer causes a substantial burden worldwide and exhibit a positive association with the socioeconomic status. With the aid of improving screening modalities, preventable nature of the disease (due to dietary and lifestyle risk factors) and improving treatment procedures, the burden of CRC can largely be curtailed. The high burden of CRC in developing countries, therefore, calls for effective prevention strategies, cost-effective screening, and early-stage detection, cost-effective predictive, and personalized treatment regime.</description><subject>Age</subject><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Care and treatment</subject><subject>Colorectal cancer</subject><subject>Developing countries</subject><subject>Human development</subject><subject>Industrialized countries</subject><subject>Medical research</subject><subject>Medicine/Public Health</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Prevention</subject><subject>Proxy</subject><subject>Social class</subject><subject>Socioeconomic factors</subject><subject>Socioeconomic status</subject><issn>1878-5077</issn><issn>1878-5085</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9Uk1v1DAUtCpQWy39AxyQJS5cUvwRf4QD0nYFBWnVvcDZcpyXxVViFzup2H-P2y1bilDtg5_8ZuZpngah15ScU0LU-0w5laoitKkIoVpUuyN0SrXSlSBavDjUSp2gs5yvSTmc6UI9Riec0bqQ9Ckyy4Dhlx19sJOPAcceuzjEBG6yA3Y2OEi4nVMHAbc7nKPzEVwMcfQO58lOc_6A4daXvgPcpzjiy_XmYrNaXmFWRrxCL3s7ZDh7eBfo--dP31ZfqvXm8utqua6cJGqqhO2I1FYKDhJ620lFu7rjLTSMNr0Utq5FQx3IljSiZUQy7qQiStYdWC00X6CPe92buR2hcxCmZAdzk_xo085E683TTvA_zDbeGkWY1o0qAu8eBFL8OUOezOizg2GwAeKcDeOq5lTX99C3_0Cv45xCsVdQQgkqBOGPqK0dwPjQxzLX3YmapSSEsbopLhbo_D-ocjsoG44Bel_-nxDYnuBSzDlBf_BIiblLhtknw5RkmPtkmF0hvfl7OwfKnxwUAN8DcmmFLaRHS8_I_ga5yMG8</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Sharma, Rajesh</creator><general>Springer International Publishing</general><general>BioMed Central Ltd</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200301</creationdate><title>An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018</title><author>Sharma, Rajesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-5ad068a653e6efad671d4d3be9219f65a44591ce6b095b20623c670764dea8583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Care and treatment</topic><topic>Colorectal cancer</topic><topic>Developing countries</topic><topic>Human development</topic><topic>Industrialized countries</topic><topic>Medical research</topic><topic>Medicine/Public Health</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Prevention</topic><topic>Proxy</topic><topic>Social class</topic><topic>Socioeconomic factors</topic><topic>Socioeconomic status</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Rajesh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EPMA journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Rajesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018</atitle><jtitle>The EPMA journal</jtitle><stitle>EPMA Journal</stitle><addtitle>EPMA J</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>11</volume><issue>1</issue><spage>95</spage><epage>117</epage><pages>95-117</pages><issn>1878-5077</issn><eissn>1878-5085</eissn><abstract>Aim and background
Colon and rectum (colorectal) cancer cause substantial mortality and morbidity worldwide. The management and control of a complex disease such as cancer cannot rely on the old strategy of “one disease one medicine” and must make a transition into new-age practices involving predictive, preventive, and personalized medicine (PPPM) at its core. Adoption of PPPM approach to cancer management at the policy level requires quantification of cancer burden at the country level. For this purpose, we examine the burden of colorectal cancer in 185 countries in 2018. Based on results, we discuss the opportunities presented by PPPM and challenges to be encountered while adopting PPPM for the treatment and prevention of colorectal cancer.
Data and methods
Age- and sex-wise estimates of colorectal cancer were procured from the GLOBOCAN 2018. The country- and region-wise burden of colorectal cancer in 185 countries was examined using all-age and age-standardized incidence and mortality estimates. Human development index (HDI) was employed as the indicator of socioeconomic status of a country. Mortality-to-incidence ratio (MIR) was employed as the proxy of 5-year survival rate.
Results
Globally, colorectal cancer claimed an estimated 880,792 lives (males 484,224; females 396,568) with 1.85 million new cases (males 1.03 million; females 823,303) were estimated to be diagnosed in 2018. Globally, the age-standardized incidence rate (ASIR) was 19.7/100,000, whereas age-standardized mortality rate (ASMR) recorded to be 16.3/100,000 in 2018. Age-standardized rates were the highest in developed countries led by Hungary with ASIR of 51.2/100,000 followed by South Korea with ASIR of 44.5/100,000. ASMR followed the patterns of ASIR with the highest ASMR recorded by Hungary (21.5 per 100,000) and Slovakia (20.4 per 100,000). Globally, MIR stood at 0.48, and among the countries recording more than 1000 cases, Nepal registered the highest MIR of 0.83 and the lowest was recorded by South Korea (0.27). The age-standardized rates exhibited nonlinear association with HDI, whereas MIR was negatively associated with HDI.
Conclusion
Colorectal cancer causes a substantial burden worldwide and exhibit a positive association with the socioeconomic status. With the aid of improving screening modalities, preventable nature of the disease (due to dietary and lifestyle risk factors) and improving treatment procedures, the burden of CRC can largely be curtailed. The high burden of CRC in developing countries, therefore, calls for effective prevention strategies, cost-effective screening, and early-stage detection, cost-effective predictive, and personalized treatment regime.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32140188</pmid><doi>10.1007/s13167-019-00185-y</doi><tpages>23</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Analysis Biomedical and Life Sciences Biomedicine Care and treatment Colorectal cancer Developing countries Human development Industrialized countries Medical research Medicine/Public Health Morbidity Mortality Prevention Proxy Social class Socioeconomic factors Socioeconomic status |
| title | An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018 |
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