High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases

High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging featur...

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Veröffentlicht in:	American journal of neuroradiology : AJNR 2019-02, Vol.40 (2), p.366-369
Hauptverfasser:	Spyris, C D, Castellino, R C, Schniederjan, M J, Kadom, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - etiology Brain Neoplasms - pathology Child Child, Preschool Female Glioma - etiology Glioma - pathology Humans Male Neurofibromatosis 1 - complications Pediatrics
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container_title	American journal of neuroradiology : AJNR
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creator	Spyris, C D Castellino, R C Schniederjan, M J Kadom, N
description	High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.
doi_str_mv	10.3174/ajnr.A5888
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subjects	Brain Neoplasms - etiology Brain Neoplasms - pathology Child Child, Preschool Female Glioma - etiology Glioma - pathology Humans Male Neurofibromatosis 1 - complications Pediatrics
title	High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases
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