Red blood cell transfusion results in adhesion of neutrophils in human endotoxemia and in critically ill patients with sepsis

BACKGROUND Red blood cell (RBC) transfusion is associated with adverse effects, which may involve activation of the host immune response. The effect of RBC transfusion on neutrophil Reactive Oxygen Species (ROS) production and adhesion ex vivo was investigated in endotoxemic volunteers and in critic...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2020-02, Vol.60 (2), p.294-302
Hauptverfasser:	Hezel, Maike E., Boshuizen, Margit, Peters, Anna L., Straat, M., Vlaar, Alexander P., Spoelstra ‐ de Man, Angelique M.E., Tanck, Michael W.T., Tool, Anton T.J., Beuger, Boukje M., Kuijpers, Taco W., Juffermans, Nicole P., Bruggen, Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adhesion tests Blood transfusion Cell activation Endotoxemia Erythrocytes Immune response Inflammation Leukocytes (neutrophilic) Lipopolysaccharides Neutrophils Priming Reactive oxygen species Sepsis Storage Transfusion Transfusion Complications
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