High COX‐2 expression in cancer‐associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck cancers, and distant metastasis is the major reason for treatment failure. We have previously shown that high cyclooxygenase‐2 (COX‐2) expression is associated with a poor prognosis of patients with NPC and inhibit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular carcinogenesis 2020-03, Vol.59 (3), p.265-280
Hauptverfasser:	Zhu, Yinghong, Shi, Chen, Zeng, Liang, Liu, Guizhu, Jiang, Weihong, Zhang, Xin, Chen, Shilian, Guo, Jiaojiao, Jian, Xingxing, Ouyang, Jian, Xia, Jiliang, Kuang, Chunmei, Fan, Songqing, Wu, Xuan, Wu, Yangbowen, Zhou, Wen, Guan, Yongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer-Associated Fibroblasts - pathology cancer‐associated fibroblasts Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Chemotherapy COX‐2 Cyclooxygenase 2 - genetics Female Fibroblasts Gene Expression Regulation, Neoplastic Head & neck cancer Humans Immunohistochemistry Invasiveness Male Medical prognosis Metastases Metastasis Mice Mice, Knockout Middle Aged Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - diagnosis Nasopharyngeal Carcinoma - genetics Nasopharyngeal Carcinoma - pathology Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Prognosis Prostaglandin E2 Prostaglandin endoperoxide synthase Ribonucleic acid RNA Senescence Throat cancer Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!