A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

Loss‐of‐function genetic variants of triggering receptor expressed on myeloid cells 2 (TREM2) are linked with an enhanced risk of developing dementias. Microglia, the resident immune cell of the brain, express TREM2, and microglial responses are implicated in dementia pathways. In a normal surveilla...

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Veröffentlicht in:	The FASEB journal 2020-02, Vol.34 (2), p.2436-2450
Hauptverfasser:	Piers, Thomas M., Cosker, Katharina, Mallach, Anna, Johnson, Gabriel Thomas, Guerreiro, Rita, Hardy, John, Pocock, Jennifer M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Cell Differentiation - genetics Cell Line glycolysis Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Loss of Function Mutation Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism metabolism microglia Microglia - metabolism Microglia - pathology Receptors, Immunologic - genetics Receptors, Immunologic - metabolism
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