Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti‐HER2 agents in the real world setting

We analyzed data from 738 HER2‐positive metastatic breast cancer (mbc) patients treated with pertuzumab‐based regimens and/or T‐DM1 at 45 Italian centers. Outcomes were explored in relation to tumor subtype assessed by immunohistochemistry (IHC). The median progression‐free survival at first‐line (m...

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Veröffentlicht in:	International journal of cancer 2020-04, Vol.146 (7), p.1917-1929
Hauptverfasser:	Pizzuti, Laura, Krasniqi, Eriseld, Barchiesi, Giacomo, Della Giulia, Marina, Izzo, Fiorentino, Sanguineti, Giuseppe, Marchetti, Paolo, Mazzotta, Marco, Giusti, Raffaele, Botticelli, Andrea, Gamucci, Teresa, Natoli, Clara, Grassadonia, Antonino, Tinari, Nicola, Iezzi, Laura, Tomao, Silverio, Tomao, Federica, Tonini, Giuseppe, Santini, Daniele, Astone, Antonio, Michelotti, Andrea, De Angelis, Claudia, Mentuccia, Lucia, Vaccaro, Angela, Magnolfi, Emanuela, Gelibter, Alain, Magri, Valentina, Cortesi, Enrico, D'Onofrio, Loretta, Cassano, Alessandra, Rossi, Ernesto, Cazzaniga, Marina, Moscetti, Luca, Omarini, Claudia, Piacentini, Federico, Fabbri, Maria A., Scinto, Angelo F., Corsi, Domenico, Carbognin, Luisa, Bria, Emilio, La Verde, Nicla, Samaritani, Riccardo, Garufi, Carlo, Barni, Sandro, Mirabelli, Rosanna, Sarmiento, Roberta, Veltri, Enzo M., D'Auria, Giuliana, Paris, Ida, Giotta, Francesco, Lorusso, Vito, Cardillo, Franca, Landucci, Elisabetta, Mauri, Maria, Ficorella, Corrado, Roselli, Mario, Adamo, Vincenzo, Ricciardi, Giuseppina R.R., Russo, Antonio, Berardi, Rossana, Pistelli, Mirco, Fiorio, Elena, Cannita, Katia, Sini, Valentina, D'Ostilio, Nicola, Foglietta, Jennifer, Greco, Filippo, Zamagni, Claudio, Garrone, Ornella, Di Cocco, Barbara, Baldini, Editta, Livi, Lorenzo, Desideri, Isacco, Meattini, Icro, Sarobba, Giuseppina, Del Medico, Pietro, De Tursi, Michele, Generali, Daniele, De Maria, Ruggero, Risi, Emanuela, Ciliberto, Gennaro, Sperduti, Isabella, Villa, Alice, Barba, Maddalena, Di Leo, Angelo, Vici, Patrizia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult advanced breast cancer Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - mortality Cancer Cancer Therapy and Prevention ErbB-2 protein Female Gene Expression Regulation, Neoplastic HER2 positive Humans Immunohistochemistry Immunotherapy Medical research Metastases Metastasis Middle Aged Molecular Targeted Therapy Monoclonal antibodies Multivariate analysis Neoplasm Metastasis Neoplasm Staging Patients pertuzumab Prognosis real world Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Survival Targeted cancer therapy trastuzumab Tumors T‐DM1
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