Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity

The association between obesity and cardiovascular disease (CVD) is proven, but why some adults with obesity develop CVD while others remain disease-free is poorly understood. Here, we investigated whether mitochondrial DNA (mtDNA) methylation in platelets is altered prior to CVD development in a po...

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Veröffentlicht in:	Clinical epigenetics 2020-02, Vol.12 (1), p.29-29, Article 29
Hauptverfasser:	Corsi, Sarah, Iodice, Simona, Vigna, Luisella, Cayir, Akin, Mathers, John C, Bollati, Valentina, Byun, Hyang-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aged Analysis Biomarkers Bisulfite Blood glucose Blood Glucose - analysis Blood levels Blood Platelets - metabolism Blood pressure Blood Pressure - genetics Body weight Carbon dioxide Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Case-Control Studies Cholesterol Cytochrome c Deoxyribonucleic acid Diseases DNA DNA methylation DNA Methylation - genetics DNA, Mitochondrial - genetics Electron Transport Complex IV - metabolism Fasting Fasting - blood Female Genomes Glucose Humans Incidence Inflammation - metabolism Laboratory testing Leucine Logistic Models Male Methylation Middle Aged Mitochondrial DNA Novels Obesity Obesity - complications Obesity - genetics Overweight Overweight - complications Overweight - genetics Oxidases Phenylalanine Platelets Prognosis Replication origins Risk Factors RNA RNA, Transfer, Leu - metabolism Sulfites Transfer RNA tRNA Leu tRNA Phe
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