Mechanistic Insights into Specific G Protein Interactions with Adenosine Receptors

Coupling between G-protein-coupled receptors (GPCRs) and the G proteins is a key step in cellular signaling. Despite extensive experimental and computational studies, the mechanism of specific GPCR–G protein coupling remains poorly understood. This has greatly hindered effective drug design of GPCRs...

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Veröffentlicht in:	The journal of physical chemistry. B 2019-08, Vol.123 (30), p.6462-6473
Hauptverfasser:	Wang, Jinan, Miao, Yinglong
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine agonists cell communication drug design drugs G-proteins Gibbs free energy GTP-Binding Proteins - chemistry GTP-Binding Proteins - metabolism Models, Molecular molecular dynamics Molecular Dynamics Simulation Protein Binding Protein Conformation purinergic receptors Receptors, Purinergic P1 - chemistry Receptors, Purinergic P1 - metabolism Thermodynamics
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