Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats

Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF). The mechanisms of cardioprotective effects of donepezil, however, remain totally unknown. To elucidate potential mechanisms, we examined whether centra...

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Veröffentlicht in:	The journal of physiological sciences 2020-02, Vol.70 (1), p.11-11, Article 11
Hauptverfasser:	Li, Meihua, Zheng, Can, Kawada, Toru, Inagaki, Masashi, Uemura, Kazunori, Sugimachi, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Alzheimer's disease Angiotensin Angiotensin II Animals Aprotinin Blood pressure Brain natriuretic peptide Cardiac remodeling Carotid arteries Catecholamines Catheters Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - pharmacology Chronic heart failure Comparative analysis Congestive heart failure Digitization Donepezil Donepezil - administration & dosage Donepezil - pharmacology Enzyme inhibitors Enzymes Ethylenediaminetetraacetic acid Fibrosis - pathology Fibrosis - prevention & control Heart attack Heart attacks Heart failure Heart Failure - drug therapy Heart Failure - pathology Immunoassay Injections, Intraventricular Intracerebroventricular infusion Laboratory animals Male Medical prognosis Myocardial infarction Natriuretic peptides Oral administration Original Paper Physiology Prevention Prognosis Random Allocation Rats Rats, Sprague-Dawley Survival Survival rate Veins & arteries Ventricular Remodeling - drug effects
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