Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance
Background Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure “in vivo” duodenal and jejunal baseline impedance (BI) and (b)...
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| Veröffentlicht in: | Journal of gastroenterology 2020-03, Vol.55 (3), p.273-280 |
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| creator | Nakagawa, Kenichiro Hara, Ken Fikree, Asma Siddiqi, Shahab Woodland, Philip Masamune, Atsushi Aziz, Qasim Sifrim, Daniel Yazaki, Etsuro |
| description | Background
Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure “in vivo” duodenal and jejunal baseline impedance (BI) and (b) to assess small bowel mucosal integrity in patients with functional dyspepsia (FD) and healthy controls (HC).
Methods
We recruited 16 patients with FD and 15 HC. All subjects underwent ambulatory duodeno-jejunal manometry combined with impedance (HRM/Z), BI were determined by measuring impedance immediately after the passage of nocturnal migrating motor complex (MMC) phase IIIs.
Results
The number of MMC phase IIIs in FD was significantly lower than that in HC (2.6 ± 1.4 vs 4.8 ± 1.7,
p
|
| doi_str_mv | 10.1007/s00535-019-01614-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7026227</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714582938</galeid><sourcerecordid>A714582938</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-2525de1ffa89cfc2c8b52a6e02c92fa068f8888db30b563c66a618a4307832043</originalsourceid><addsrcrecordid>eNp9ks1u1DAUhSMEokPhBVggS2zYpPgndhwWSFXFn1QJFrC2bpybjEeOPcTJVPNCPCeeTmkpqkgUOfL9zrm-1imKl4yeMUrrt4lSKWRJWZM_xapSPipWrMpbsuH8cbGiTVWVjNXVSfEspQ2lTFCpnxYnglVKM12til_fYHYY5kSu3Lwm3T5tcZsckDXskLhxC27CjoyLjQk8cWHGYXLznrQx4y6QeY2kW2KHYRkJhI5scLPk_3eH4s7tIoGUMKUxNyGxJ2kE77P6Cv0DrktyYSAtJPQuXPfHDoLF58WTHnzCFzfrafHj44fvF5_Ly6-fvlycX5ZWKjmXXHLZIet70I3tLbe6lRwUUm4b3gNVutf56VpBW6mEVQoU01AJWmvBaSVOi_dH3-3SjtjZfOgJvNlOboRpbyI4c78S3NoMcWdqyhXndTZ4c2MwxZ8LptmMLln0HgLGJRnOtWBUN02T0df_oJu4TCGPd6C4YFwJcUcN4NG40Mfc1x5MzXnNKql5I3Smzh6g8tvh6GwM2Lu8f0_AjwI7xZQm7G9nZNQc0mWO6TI5XeY6XUZm0au_b-dW8idOGRBHIOVSGHC6G-k_tr8BqH3dgQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2282312633</pqid></control><display><type>article</type><title>Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance</title><source>SpringerNature Journals</source><creator>Nakagawa, Kenichiro ; Hara, Ken ; Fikree, Asma ; Siddiqi, Shahab ; Woodland, Philip ; Masamune, Atsushi ; Aziz, Qasim ; Sifrim, Daniel ; Yazaki, Etsuro</creator><creatorcontrib>Nakagawa, Kenichiro ; Hara, Ken ; Fikree, Asma ; Siddiqi, Shahab ; Woodland, Philip ; Masamune, Atsushi ; Aziz, Qasim ; Sifrim, Daniel ; Yazaki, Etsuro</creatorcontrib><description>Background
Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure “in vivo” duodenal and jejunal baseline impedance (BI) and (b) to assess small bowel mucosal integrity in patients with functional dyspepsia (FD) and healthy controls (HC).
Methods
We recruited 16 patients with FD and 15 HC. All subjects underwent ambulatory duodeno-jejunal manometry combined with impedance (HRM/Z), BI were determined by measuring impedance immediately after the passage of nocturnal migrating motor complex (MMC) phase IIIs.
Results
The number of MMC phase IIIs in FD was significantly lower than that in HC (2.6 ± 1.4 vs 4.8 ± 1.7,
p
< 0.001). The BI in patients was significantly lower than that in HC in D1(164.2 ± 59.8 Ω in FD and 243.1 ± 40.5 Ω in HC,
p
= 0.0061), D2 (191.2 ± 34.1 and 256.5 ± 91.4 Ω,
p
= 0.01), D3 (214.0 ± 76.9 and 278.1 ± 45.3 Ω,
p
= 0.009), D4 (270.8 ± 54.2 and 351.8 ± 50.2 Ω,
p
< 0.001), and J1 (312.2 ± 55.4 and 379.3 ± 38.3 Ω,
p
= 0.001).
Conclusions
This is the first study reporting the duodenal and jejunal BI in vivo. The results have shown significantly lowered BI in the proximal small intestine in patients with FD compared to HC. Furthermore it suggests that measurements of small bowel BI could be used as a biomarker for diagnosis and follow up of patients with FD.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-019-01614-5</identifier><identifier>PMID: 31468184</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Abdominal Surgery ; Analysis ; Biopsy ; Colorectal Surgery ; Duodenum ; Dyspepsia ; Gastroenterology ; Hepatology ; Jejunum ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Mucosa ; Original Article—Alimentary Tract ; Original —Alimentary Tract ; Small intestine ; Surgical Oncology</subject><ispartof>Journal of gastroenterology, 2020-03, Vol.55 (3), p.273-280</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Journal of Gastroenterology is a copyright of Springer, (2019). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-2525de1ffa89cfc2c8b52a6e02c92fa068f8888db30b563c66a618a4307832043</citedby><cites>FETCH-LOGICAL-c565t-2525de1ffa89cfc2c8b52a6e02c92fa068f8888db30b563c66a618a4307832043</cites><orcidid>0000-0002-5315-4957</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-019-01614-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-019-01614-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31468184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakagawa, Kenichiro</creatorcontrib><creatorcontrib>Hara, Ken</creatorcontrib><creatorcontrib>Fikree, Asma</creatorcontrib><creatorcontrib>Siddiqi, Shahab</creatorcontrib><creatorcontrib>Woodland, Philip</creatorcontrib><creatorcontrib>Masamune, Atsushi</creatorcontrib><creatorcontrib>Aziz, Qasim</creatorcontrib><creatorcontrib>Sifrim, Daniel</creatorcontrib><creatorcontrib>Yazaki, Etsuro</creatorcontrib><title>Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure “in vivo” duodenal and jejunal baseline impedance (BI) and (b) to assess small bowel mucosal integrity in patients with functional dyspepsia (FD) and healthy controls (HC).
Methods
We recruited 16 patients with FD and 15 HC. All subjects underwent ambulatory duodeno-jejunal manometry combined with impedance (HRM/Z), BI were determined by measuring impedance immediately after the passage of nocturnal migrating motor complex (MMC) phase IIIs.
Results
The number of MMC phase IIIs in FD was significantly lower than that in HC (2.6 ± 1.4 vs 4.8 ± 1.7,
p
< 0.001). The BI in patients was significantly lower than that in HC in D1(164.2 ± 59.8 Ω in FD and 243.1 ± 40.5 Ω in HC,
p
= 0.0061), D2 (191.2 ± 34.1 and 256.5 ± 91.4 Ω,
p
= 0.01), D3 (214.0 ± 76.9 and 278.1 ± 45.3 Ω,
p
= 0.009), D4 (270.8 ± 54.2 and 351.8 ± 50.2 Ω,
p
< 0.001), and J1 (312.2 ± 55.4 and 379.3 ± 38.3 Ω,
p
= 0.001).
Conclusions
This is the first study reporting the duodenal and jejunal BI in vivo. The results have shown significantly lowered BI in the proximal small intestine in patients with FD compared to HC. Furthermore it suggests that measurements of small bowel BI could be used as a biomarker for diagnosis and follow up of patients with FD.</description><subject>Abdominal Surgery</subject><subject>Analysis</subject><subject>Biopsy</subject><subject>Colorectal Surgery</subject><subject>Duodenum</subject><subject>Dyspepsia</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Jejunum</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Mucosa</subject><subject>Original Article—Alimentary Tract</subject><subject>Original —Alimentary Tract</subject><subject>Small intestine</subject><subject>Surgical Oncology</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9ks1u1DAUhSMEokPhBVggS2zYpPgndhwWSFXFn1QJFrC2bpybjEeOPcTJVPNCPCeeTmkpqkgUOfL9zrm-1imKl4yeMUrrt4lSKWRJWZM_xapSPipWrMpbsuH8cbGiTVWVjNXVSfEspQ2lTFCpnxYnglVKM12til_fYHYY5kSu3Lwm3T5tcZsckDXskLhxC27CjoyLjQk8cWHGYXLznrQx4y6QeY2kW2KHYRkJhI5scLPk_3eH4s7tIoGUMKUxNyGxJ2kE77P6Cv0DrktyYSAtJPQuXPfHDoLF58WTHnzCFzfrafHj44fvF5_Ly6-fvlycX5ZWKjmXXHLZIet70I3tLbe6lRwUUm4b3gNVutf56VpBW6mEVQoU01AJWmvBaSVOi_dH3-3SjtjZfOgJvNlOboRpbyI4c78S3NoMcWdqyhXndTZ4c2MwxZ8LptmMLln0HgLGJRnOtWBUN02T0df_oJu4TCGPd6C4YFwJcUcN4NG40Mfc1x5MzXnNKql5I3Smzh6g8tvh6GwM2Lu8f0_AjwI7xZQm7G9nZNQc0mWO6TI5XeY6XUZm0au_b-dW8idOGRBHIOVSGHC6G-k_tr8BqH3dgQ</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Nakagawa, Kenichiro</creator><creator>Hara, Ken</creator><creator>Fikree, Asma</creator><creator>Siddiqi, Shahab</creator><creator>Woodland, Philip</creator><creator>Masamune, Atsushi</creator><creator>Aziz, Qasim</creator><creator>Sifrim, Daniel</creator><creator>Yazaki, Etsuro</creator><general>Springer Singapore</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5315-4957</orcidid></search><sort><creationdate>20200301</creationdate><title>Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance</title><author>Nakagawa, Kenichiro ; Hara, Ken ; Fikree, Asma ; Siddiqi, Shahab ; Woodland, Philip ; Masamune, Atsushi ; Aziz, Qasim ; Sifrim, Daniel ; Yazaki, Etsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-2525de1ffa89cfc2c8b52a6e02c92fa068f8888db30b563c66a618a4307832043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Surgery</topic><topic>Analysis</topic><topic>Biopsy</topic><topic>Colorectal Surgery</topic><topic>Duodenum</topic><topic>Dyspepsia</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Jejunum</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Mucosa</topic><topic>Original Article—Alimentary Tract</topic><topic>Original —Alimentary Tract</topic><topic>Small intestine</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakagawa, Kenichiro</creatorcontrib><creatorcontrib>Hara, Ken</creatorcontrib><creatorcontrib>Fikree, Asma</creatorcontrib><creatorcontrib>Siddiqi, Shahab</creatorcontrib><creatorcontrib>Woodland, Philip</creatorcontrib><creatorcontrib>Masamune, Atsushi</creatorcontrib><creatorcontrib>Aziz, Qasim</creatorcontrib><creatorcontrib>Sifrim, Daniel</creatorcontrib><creatorcontrib>Yazaki, Etsuro</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakagawa, Kenichiro</au><au>Hara, Ken</au><au>Fikree, Asma</au><au>Siddiqi, Shahab</au><au>Woodland, Philip</au><au>Masamune, Atsushi</au><au>Aziz, Qasim</au><au>Sifrim, Daniel</au><au>Yazaki, Etsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>55</volume><issue>3</issue><spage>273</spage><epage>280</epage><pages>273-280</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure “in vivo” duodenal and jejunal baseline impedance (BI) and (b) to assess small bowel mucosal integrity in patients with functional dyspepsia (FD) and healthy controls (HC).
Methods
We recruited 16 patients with FD and 15 HC. All subjects underwent ambulatory duodeno-jejunal manometry combined with impedance (HRM/Z), BI were determined by measuring impedance immediately after the passage of nocturnal migrating motor complex (MMC) phase IIIs.
Results
The number of MMC phase IIIs in FD was significantly lower than that in HC (2.6 ± 1.4 vs 4.8 ± 1.7,
p
< 0.001). The BI in patients was significantly lower than that in HC in D1(164.2 ± 59.8 Ω in FD and 243.1 ± 40.5 Ω in HC,
p
= 0.0061), D2 (191.2 ± 34.1 and 256.5 ± 91.4 Ω,
p
= 0.01), D3 (214.0 ± 76.9 and 278.1 ± 45.3 Ω,
p
= 0.009), D4 (270.8 ± 54.2 and 351.8 ± 50.2 Ω,
p
< 0.001), and J1 (312.2 ± 55.4 and 379.3 ± 38.3 Ω,
p
= 0.001).
Conclusions
This is the first study reporting the duodenal and jejunal BI in vivo. The results have shown significantly lowered BI in the proximal small intestine in patients with FD compared to HC. Furthermore it suggests that measurements of small bowel BI could be used as a biomarker for diagnosis and follow up of patients with FD.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31468184</pmid><doi>10.1007/s00535-019-01614-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5315-4957</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of gastroenterology, 2020-03, Vol.55 (3), p.273-280 |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Abdominal Surgery Analysis Biopsy Colorectal Surgery Duodenum Dyspepsia Gastroenterology Hepatology Jejunum Medical research Medicine Medicine & Public Health Medicine, Experimental Mucosa Original Article—Alimentary Tract Original —Alimentary Tract Small intestine Surgical Oncology |
| title | Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance |
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