Chromosomal origin of replication coordinates logically distinct types of bacterial genetic regulation

For a long time it has been hypothesized that bacterial gene regulation involves an intricate interplay of the transcriptional regulatory network (TRN) and the spatial organization of genes in the chromosome. Here we explore this hypothesis both on a structural and on a functional level. On the stru...

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Veröffentlicht in:	NPJ systems biology and applications 2020-02, Vol.6 (1), p.5-5, Article 5
Hauptverfasser:	Kosmidis, Kosmas, Jablonski, Kim Philipp, Muskhelishvili, Georgi, Hütt, Marc-Thorsten
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/208/2490 631/553/2711 Bacteria - genetics Bioinformatics Biomedical and Life Sciences Chromosomes Chromosomes, Bacterial - metabolism Coevolution Computational Biology/Bioinformatics Computer Appl. in Life Sciences DNA microarrays DNA, Bacterial - genetics Embedding Escherichia coli - genetics Escherichia coli Proteins - genetics Gene expression Gene Expression Regulation, Bacterial - genetics Gene regulation Gene Regulatory Networks - genetics Genetic control Learning algorithms Life Sciences Machine learning Regulatory Elements, Transcriptional - genetics Replication Origin - genetics Replication Origin - physiology Replication origins Ribonucleic acid RNA Systems Biology Transcription
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