Antithrombotic effect of SP‐8008, a benzoic acid derivative, through the selective inhibition of shear stress‐induced platelet aggregation

Background and Purpose Bleeding is one of the most critical adverse effects of antithrombotic drugs, and many efforts have been made to discover novel antiplatelet agents without bleeding complications. Shear stress‐induced platelet aggregation (SIPA), where the interaction of von Willebrand factor...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	British journal of pharmacology 2020-02, Vol.177 (4), p.929-944
Hauptverfasser:	Ngo, Thien, Kim, Keunyoung, Bian, Yiying, Nam, Gibeom, Park, Hyun‐Ju, Lee, Kiho, Cho, Geum‐Sil, Ryu, Jei‐Man, Lim, Kyung‐Min, Chung, Jin‐Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiplatelet therapy Benzoic acid Bleeding Calcium (intracellular) Flow cytometry Molecular modelling Platelet aggregation Research Paper Research Papers Shear stress Side effects Thrombosis Toxicity Von Willebrand factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!