HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical cancer research 2019-11, Vol.26 (4), p.793-803
Hauptverfasser: Courtney, Kevin D., Ma, Yuanqing, de Leon, Alberto Diaz, Christie, Alana, Xie, Zhiqun, Woolford, Layton, Singla, Nirmish, Joyce, Allison, Hill, Haley, Madhuranthakam, Ananth J., Yuan, Qing, Xi, Yin, Zhang, Yue, Chang, Jenny, Fatunde, Oluwatomilade, Arriaga, Yull, Frankel, Arthur, Kalva, Sanjeeva, Zhang, Song, McKenzie, Tiffani, Torras, Oscar Reig, Figlin, Robert A., Rini, Brian I., McKay, Renée M., Kapur, Payal, Wang, Tao, Pedrosa, Ivan, Brugarolas, James
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 803
container_issue 4
container_start_page 793
container_title Clinical cancer research
container_volume 26
creator Courtney, Kevin D.
Ma, Yuanqing
de Leon, Alberto Diaz
Christie, Alana
Xie, Zhiqun
Woolford, Layton
Singla, Nirmish
Joyce, Allison
Hill, Haley
Madhuranthakam, Ananth J.
Yuan, Qing
Xi, Yin
Zhang, Yue
Chang, Jenny
Fatunde, Oluwatomilade
Arriaga, Yull
Frankel, Arthur
Kalva, Sanjeeva
Zhang, Song
McKenzie, Tiffani
Torras, Oscar Reig
Figlin, Robert A.
Rini, Brian I.
McKay, Renée M.
Kapur, Payal
Wang, Tao
Pedrosa, Ivan
Brugarolas, James
description
doi_str_mv 10.1158/1078-0432.CCR-19-1459
format Article
fullrecord <record><control><sourceid>pubmedcentral</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7024660</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_7024660</sourcerecordid><originalsourceid>FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_70246603</originalsourceid><addsrcrecordid>eNqljs1OwzAQhH0A0fLzCEj7ALjY-e8FCRmq9lZVuUfbxDSLHDvYKT9vw6MSKRUSZ06zmhl9O4zdSrGQMi3upcgLLpI4Wii143LJZZIuz9j815-xyxBehZCJFMkFm8Uyj_Isz-fse71Z8QiU63qjP-GJQnA14UDO3kGJ_qAH2NiW9jRZaBt4rN-O5HUDOx0oDGhrDR80tLAto7hIxxKsyIeBk-XKYAgwPTlxnAeyoIxGD0obM2IsmulU6GuyrkPYjhu0HcI1O39BE_TNSa_Yw-q5VGveH_edbuqx49FUvacO_VflkKq_iaW2Orj3KhdRkmUi_jfgBxlUdtA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients</title><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Courtney, Kevin D. ; Ma, Yuanqing ; de Leon, Alberto Diaz ; Christie, Alana ; Xie, Zhiqun ; Woolford, Layton ; Singla, Nirmish ; Joyce, Allison ; Hill, Haley ; Madhuranthakam, Ananth J. ; Yuan, Qing ; Xi, Yin ; Zhang, Yue ; Chang, Jenny ; Fatunde, Oluwatomilade ; Arriaga, Yull ; Frankel, Arthur ; Kalva, Sanjeeva ; Zhang, Song ; McKenzie, Tiffani ; Torras, Oscar Reig ; Figlin, Robert A. ; Rini, Brian I. ; McKay, Renée M. ; Kapur, Payal ; Wang, Tao ; Pedrosa, Ivan ; Brugarolas, James</creator><creatorcontrib>Courtney, Kevin D. ; Ma, Yuanqing ; de Leon, Alberto Diaz ; Christie, Alana ; Xie, Zhiqun ; Woolford, Layton ; Singla, Nirmish ; Joyce, Allison ; Hill, Haley ; Madhuranthakam, Ananth J. ; Yuan, Qing ; Xi, Yin ; Zhang, Yue ; Chang, Jenny ; Fatunde, Oluwatomilade ; Arriaga, Yull ; Frankel, Arthur ; Kalva, Sanjeeva ; Zhang, Song ; McKenzie, Tiffani ; Torras, Oscar Reig ; Figlin, Robert A. ; Rini, Brian I. ; McKay, Renée M. ; Kapur, Payal ; Wang, Tao ; Pedrosa, Ivan ; Brugarolas, James</creatorcontrib><identifier>ISSN: 1078-0432</identifier><identifier>DOI: 10.1158/1078-0432.CCR-19-1459</identifier><identifier>PMID: 31727677</identifier><language>eng</language><ispartof>Clinical cancer research, 2019-11, Vol.26 (4), p.793-803</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27931,27932</link.rule.ids></links><search><creatorcontrib>Courtney, Kevin D.</creatorcontrib><creatorcontrib>Ma, Yuanqing</creatorcontrib><creatorcontrib>de Leon, Alberto Diaz</creatorcontrib><creatorcontrib>Christie, Alana</creatorcontrib><creatorcontrib>Xie, Zhiqun</creatorcontrib><creatorcontrib>Woolford, Layton</creatorcontrib><creatorcontrib>Singla, Nirmish</creatorcontrib><creatorcontrib>Joyce, Allison</creatorcontrib><creatorcontrib>Hill, Haley</creatorcontrib><creatorcontrib>Madhuranthakam, Ananth J.</creatorcontrib><creatorcontrib>Yuan, Qing</creatorcontrib><creatorcontrib>Xi, Yin</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Chang, Jenny</creatorcontrib><creatorcontrib>Fatunde, Oluwatomilade</creatorcontrib><creatorcontrib>Arriaga, Yull</creatorcontrib><creatorcontrib>Frankel, Arthur</creatorcontrib><creatorcontrib>Kalva, Sanjeeva</creatorcontrib><creatorcontrib>Zhang, Song</creatorcontrib><creatorcontrib>McKenzie, Tiffani</creatorcontrib><creatorcontrib>Torras, Oscar Reig</creatorcontrib><creatorcontrib>Figlin, Robert A.</creatorcontrib><creatorcontrib>Rini, Brian I.</creatorcontrib><creatorcontrib>McKay, Renée M.</creatorcontrib><creatorcontrib>Kapur, Payal</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Pedrosa, Ivan</creatorcontrib><creatorcontrib>Brugarolas, James</creatorcontrib><title>HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients</title><title>Clinical cancer research</title><issn>1078-0432</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqljs1OwzAQhH0A0fLzCEj7ALjY-e8FCRmq9lZVuUfbxDSLHDvYKT9vw6MSKRUSZ06zmhl9O4zdSrGQMi3upcgLLpI4Wii143LJZZIuz9j815-xyxBehZCJFMkFm8Uyj_Isz-fse71Z8QiU63qjP-GJQnA14UDO3kGJ_qAH2NiW9jRZaBt4rN-O5HUDOx0oDGhrDR80tLAto7hIxxKsyIeBk-XKYAgwPTlxnAeyoIxGD0obM2IsmulU6GuyrkPYjhu0HcI1O39BE_TNSa_Yw-q5VGveH_edbuqx49FUvacO_VflkKq_iaW2Orj3KhdRkmUi_jfgBxlUdtA</recordid><startdate>20191114</startdate><enddate>20191114</enddate><creator>Courtney, Kevin D.</creator><creator>Ma, Yuanqing</creator><creator>de Leon, Alberto Diaz</creator><creator>Christie, Alana</creator><creator>Xie, Zhiqun</creator><creator>Woolford, Layton</creator><creator>Singla, Nirmish</creator><creator>Joyce, Allison</creator><creator>Hill, Haley</creator><creator>Madhuranthakam, Ananth J.</creator><creator>Yuan, Qing</creator><creator>Xi, Yin</creator><creator>Zhang, Yue</creator><creator>Chang, Jenny</creator><creator>Fatunde, Oluwatomilade</creator><creator>Arriaga, Yull</creator><creator>Frankel, Arthur</creator><creator>Kalva, Sanjeeva</creator><creator>Zhang, Song</creator><creator>McKenzie, Tiffani</creator><creator>Torras, Oscar Reig</creator><creator>Figlin, Robert A.</creator><creator>Rini, Brian I.</creator><creator>McKay, Renée M.</creator><creator>Kapur, Payal</creator><creator>Wang, Tao</creator><creator>Pedrosa, Ivan</creator><creator>Brugarolas, James</creator><scope>5PM</scope></search><sort><creationdate>20191114</creationdate><title>HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients</title><author>Courtney, Kevin D. ; Ma, Yuanqing ; de Leon, Alberto Diaz ; Christie, Alana ; Xie, Zhiqun ; Woolford, Layton ; Singla, Nirmish ; Joyce, Allison ; Hill, Haley ; Madhuranthakam, Ananth J. ; Yuan, Qing ; Xi, Yin ; Zhang, Yue ; Chang, Jenny ; Fatunde, Oluwatomilade ; Arriaga, Yull ; Frankel, Arthur ; Kalva, Sanjeeva ; Zhang, Song ; McKenzie, Tiffani ; Torras, Oscar Reig ; Figlin, Robert A. ; Rini, Brian I. ; McKay, Renée M. ; Kapur, Payal ; Wang, Tao ; Pedrosa, Ivan ; Brugarolas, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_70246603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Courtney, Kevin D.</creatorcontrib><creatorcontrib>Ma, Yuanqing</creatorcontrib><creatorcontrib>de Leon, Alberto Diaz</creatorcontrib><creatorcontrib>Christie, Alana</creatorcontrib><creatorcontrib>Xie, Zhiqun</creatorcontrib><creatorcontrib>Woolford, Layton</creatorcontrib><creatorcontrib>Singla, Nirmish</creatorcontrib><creatorcontrib>Joyce, Allison</creatorcontrib><creatorcontrib>Hill, Haley</creatorcontrib><creatorcontrib>Madhuranthakam, Ananth J.</creatorcontrib><creatorcontrib>Yuan, Qing</creatorcontrib><creatorcontrib>Xi, Yin</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Chang, Jenny</creatorcontrib><creatorcontrib>Fatunde, Oluwatomilade</creatorcontrib><creatorcontrib>Arriaga, Yull</creatorcontrib><creatorcontrib>Frankel, Arthur</creatorcontrib><creatorcontrib>Kalva, Sanjeeva</creatorcontrib><creatorcontrib>Zhang, Song</creatorcontrib><creatorcontrib>McKenzie, Tiffani</creatorcontrib><creatorcontrib>Torras, Oscar Reig</creatorcontrib><creatorcontrib>Figlin, Robert A.</creatorcontrib><creatorcontrib>Rini, Brian I.</creatorcontrib><creatorcontrib>McKay, Renée M.</creatorcontrib><creatorcontrib>Kapur, Payal</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Pedrosa, Ivan</creatorcontrib><creatorcontrib>Brugarolas, James</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Courtney, Kevin D.</au><au>Ma, Yuanqing</au><au>de Leon, Alberto Diaz</au><au>Christie, Alana</au><au>Xie, Zhiqun</au><au>Woolford, Layton</au><au>Singla, Nirmish</au><au>Joyce, Allison</au><au>Hill, Haley</au><au>Madhuranthakam, Ananth J.</au><au>Yuan, Qing</au><au>Xi, Yin</au><au>Zhang, Yue</au><au>Chang, Jenny</au><au>Fatunde, Oluwatomilade</au><au>Arriaga, Yull</au><au>Frankel, Arthur</au><au>Kalva, Sanjeeva</au><au>Zhang, Song</au><au>McKenzie, Tiffani</au><au>Torras, Oscar Reig</au><au>Figlin, Robert A.</au><au>Rini, Brian I.</au><au>McKay, Renée M.</au><au>Kapur, Payal</au><au>Wang, Tao</au><au>Pedrosa, Ivan</au><au>Brugarolas, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients</atitle><jtitle>Clinical cancer research</jtitle><date>2019-11-14</date><risdate>2019</risdate><volume>26</volume><issue>4</issue><spage>793</spage><epage>803</epage><pages>793-803</pages><issn>1078-0432</issn><pmid>31727677</pmid><doi>10.1158/1078-0432.CCR-19-1459</doi></addata></record>
fulltext fulltext
identifier ISSN: 1078-0432
ispartof Clinical cancer research, 2019-11, Vol.26 (4), p.793-803
issn 1078-0432
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7024660
source American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
title HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T21%3A32%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HIF-2%20Complex%20Dissociation,%20Target%20Inhibition,%20and%20Acquired%20Resistance%20with%20PT2385,%20a%20First-in-Class%20HIF-2%20Inhibitor%20in%20Clear%20Cell%20Renal%20Cell%20Carcinoma%20Patients&rft.jtitle=Clinical%20cancer%20research&rft.au=Courtney,%20Kevin%20D.&rft.date=2019-11-14&rft.volume=26&rft.issue=4&rft.spage=793&rft.epage=803&rft.pages=793-803&rft.issn=1078-0432&rft_id=info:doi/10.1158/1078-0432.CCR-19-1459&rft_dat=%3Cpubmedcentral%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_7024660%3C/pubmedcentral%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/31727677&rfr_iscdi=true