Limitations of 6‐minute walk test reference values for spinal muscular atrophy
Introduction The 6‐minute walk test (6MWT) is a well‐established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease‐modifying therapies for SMA indicates a growing need for normative reference d...
Gespeichert in:
| Veröffentlicht in: | Muscle & nerve 2020-03, Vol.61 (3), p.375-382 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 382 |
|---|---|
| container_issue | 3 |
| container_start_page | 375 |
| container_title | Muscle & nerve |
| container_volume | 61 |
| creator | Goodwin, Ashley M. Cornett, Kayla M.D. McKay, Marnee J. Burns, Joshua Garber, Carol Ewing De Vivo, Darryl C. Montes, Jacqueline |
| description | Introduction
The 6‐minute walk test (6MWT) is a well‐established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease‐modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.
Methods
The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values.
Results
Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7 ± 18.2% to 67.6 ± 26.2% and 43.0 ± 17.9% to 59.5 ± 26.2%, respectively, and were significantly different (P |
| doi_str_mv | 10.1002/mus.26794 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7024648</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2331430544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4434-73fb4c243cd59110b62686550f152567f50a8b6215c950293cf258784cb90aeb3</originalsourceid><addsrcrecordid>eNp1kc1qFTEYhoNY7OnRhTcgATd2Me2X_8xGkOJP4RQFLbgLmTRjUzOT02Sm5ey8BK_RKzGHU4sVXAWShyfv970IPSdwRADo8TCXIypVyx-hBYFWNVy0-jFaAOG6kaz9uo8OSrkCAKKleoL2GdGaK4AF-rQKQ5jsFNJYcOqx_PXj5xDGefL41sbvePJlwtn3PvvReXxj4-wL7lPGZR1GG3H9283RZmynnNaXm6dor7ex-Gd35xKdv3v75eRDs_r4_vTkzapxnDPeKNZ33FHO3IVoCYFOUqmlENATQYVUvQCr6yURrhVAW-Z6KrTS3HUtWN-xJXq9867nbvAXzo9TttGscxhs3phkg3n4MoZL8y3dGAWUS66r4NWdIKfrOtRkhlCcj9GOPs3FUMYIZyBq3CV6-Q96leZcp99SQtQtA1eVOtxRLqdS6s7uwxAw257MsNVue6rsi7_T35N_iqnA8Q64DdFv_m8yZ-efd8rfl1WdqA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2355148047</pqid></control><display><type>article</type><title>Limitations of 6‐minute walk test reference values for spinal muscular atrophy</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Goodwin, Ashley M. ; Cornett, Kayla M.D. ; McKay, Marnee J. ; Burns, Joshua ; Garber, Carol Ewing ; De Vivo, Darryl C. ; Montes, Jacqueline</creator><creatorcontrib>Goodwin, Ashley M. ; Cornett, Kayla M.D. ; McKay, Marnee J. ; Burns, Joshua ; Garber, Carol Ewing ; De Vivo, Darryl C. ; Montes, Jacqueline</creatorcontrib><description>Introduction
The 6‐minute walk test (6MWT) is a well‐established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease‐modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.
Methods
The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values.
Results
Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7 ± 18.2% to 67.6 ± 26.2% and 43.0 ± 17.9% to 59.5 ± 26.2%, respectively, and were significantly different (P < 0.001).
Discussion
Results suggest significant variability between % predicted values derived from published reference equations in children and adults, despite adherence to 6MWT standardization.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26794</identifier><identifier>PMID: 31884700</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>6‐minute walk test ; Adolescent ; Atrophy ; Child ; Child, Preschool ; Control methods ; Fatigue tests ; Female ; Humans ; Male ; Mathematical analysis ; Muscular Atrophy, Spinal - diagnosis ; Muscular Atrophy, Spinal - physiopathology ; neuromuscular disease ; Neuromuscular diseases ; normative reference ; outcome measure ; Patients ; Pediatrics ; Reference Values ; Spinal muscular atrophy ; Standardization ; Thorax ; Walk Test - standards ; Walking</subject><ispartof>Muscle & nerve, 2020-03, Vol.61 (3), p.375-382</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4434-73fb4c243cd59110b62686550f152567f50a8b6215c950293cf258784cb90aeb3</citedby><cites>FETCH-LOGICAL-c4434-73fb4c243cd59110b62686550f152567f50a8b6215c950293cf258784cb90aeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26794$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26794$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31884700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goodwin, Ashley M.</creatorcontrib><creatorcontrib>Cornett, Kayla M.D.</creatorcontrib><creatorcontrib>McKay, Marnee J.</creatorcontrib><creatorcontrib>Burns, Joshua</creatorcontrib><creatorcontrib>Garber, Carol Ewing</creatorcontrib><creatorcontrib>De Vivo, Darryl C.</creatorcontrib><creatorcontrib>Montes, Jacqueline</creatorcontrib><title>Limitations of 6‐minute walk test reference values for spinal muscular atrophy</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction
The 6‐minute walk test (6MWT) is a well‐established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease‐modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.
Methods
The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values.
Results
Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7 ± 18.2% to 67.6 ± 26.2% and 43.0 ± 17.9% to 59.5 ± 26.2%, respectively, and were significantly different (P < 0.001).
Discussion
Results suggest significant variability between % predicted values derived from published reference equations in children and adults, despite adherence to 6MWT standardization.</description><subject>6‐minute walk test</subject><subject>Adolescent</subject><subject>Atrophy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Control methods</subject><subject>Fatigue tests</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Muscular Atrophy, Spinal - diagnosis</subject><subject>Muscular Atrophy, Spinal - physiopathology</subject><subject>neuromuscular disease</subject><subject>Neuromuscular diseases</subject><subject>normative reference</subject><subject>outcome measure</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Reference Values</subject><subject>Spinal muscular atrophy</subject><subject>Standardization</subject><subject>Thorax</subject><subject>Walk Test - standards</subject><subject>Walking</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1qFTEYhoNY7OnRhTcgATd2Me2X_8xGkOJP4RQFLbgLmTRjUzOT02Sm5ey8BK_RKzGHU4sVXAWShyfv970IPSdwRADo8TCXIypVyx-hBYFWNVy0-jFaAOG6kaz9uo8OSrkCAKKleoL2GdGaK4AF-rQKQ5jsFNJYcOqx_PXj5xDGefL41sbvePJlwtn3PvvReXxj4-wL7lPGZR1GG3H9283RZmynnNaXm6dor7ex-Gd35xKdv3v75eRDs_r4_vTkzapxnDPeKNZ33FHO3IVoCYFOUqmlENATQYVUvQCr6yURrhVAW-Z6KrTS3HUtWN-xJXq9867nbvAXzo9TttGscxhs3phkg3n4MoZL8y3dGAWUS66r4NWdIKfrOtRkhlCcj9GOPs3FUMYIZyBq3CV6-Q96leZcp99SQtQtA1eVOtxRLqdS6s7uwxAw257MsNVue6rsi7_T35N_iqnA8Q64DdFv_m8yZ-efd8rfl1WdqA</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Goodwin, Ashley M.</creator><creator>Cornett, Kayla M.D.</creator><creator>McKay, Marnee J.</creator><creator>Burns, Joshua</creator><creator>Garber, Carol Ewing</creator><creator>De Vivo, Darryl C.</creator><creator>Montes, Jacqueline</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202003</creationdate><title>Limitations of 6‐minute walk test reference values for spinal muscular atrophy</title><author>Goodwin, Ashley M. ; Cornett, Kayla M.D. ; McKay, Marnee J. ; Burns, Joshua ; Garber, Carol Ewing ; De Vivo, Darryl C. ; Montes, Jacqueline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4434-73fb4c243cd59110b62686550f152567f50a8b6215c950293cf258784cb90aeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>6‐minute walk test</topic><topic>Adolescent</topic><topic>Atrophy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Control methods</topic><topic>Fatigue tests</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mathematical analysis</topic><topic>Muscular Atrophy, Spinal - diagnosis</topic><topic>Muscular Atrophy, Spinal - physiopathology</topic><topic>neuromuscular disease</topic><topic>Neuromuscular diseases</topic><topic>normative reference</topic><topic>outcome measure</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Reference Values</topic><topic>Spinal muscular atrophy</topic><topic>Standardization</topic><topic>Thorax</topic><topic>Walk Test - standards</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodwin, Ashley M.</creatorcontrib><creatorcontrib>Cornett, Kayla M.D.</creatorcontrib><creatorcontrib>McKay, Marnee J.</creatorcontrib><creatorcontrib>Burns, Joshua</creatorcontrib><creatorcontrib>Garber, Carol Ewing</creatorcontrib><creatorcontrib>De Vivo, Darryl C.</creatorcontrib><creatorcontrib>Montes, Jacqueline</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodwin, Ashley M.</au><au>Cornett, Kayla M.D.</au><au>McKay, Marnee J.</au><au>Burns, Joshua</au><au>Garber, Carol Ewing</au><au>De Vivo, Darryl C.</au><au>Montes, Jacqueline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Limitations of 6‐minute walk test reference values for spinal muscular atrophy</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2020-03</date><risdate>2020</risdate><volume>61</volume><issue>3</issue><spage>375</spage><epage>382</epage><pages>375-382</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Introduction
The 6‐minute walk test (6MWT) is a well‐established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease‐modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.
Methods
The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values.
Results
Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7 ± 18.2% to 67.6 ± 26.2% and 43.0 ± 17.9% to 59.5 ± 26.2%, respectively, and were significantly different (P < 0.001).
Discussion
Results suggest significant variability between % predicted values derived from published reference equations in children and adults, despite adherence to 6MWT standardization.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31884700</pmid><doi>10.1002/mus.26794</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-639X |
| ispartof | Muscle & nerve, 2020-03, Vol.61 (3), p.375-382 |
| issn | 0148-639X 1097-4598 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7024648 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | 6‐minute walk test Adolescent Atrophy Child Child, Preschool Control methods Fatigue tests Female Humans Male Mathematical analysis Muscular Atrophy, Spinal - diagnosis Muscular Atrophy, Spinal - physiopathology neuromuscular disease Neuromuscular diseases normative reference outcome measure Patients Pediatrics Reference Values Spinal muscular atrophy Standardization Thorax Walk Test - standards Walking |
| title | Limitations of 6‐minute walk test reference values for spinal muscular atrophy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T11%3A12%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Limitations%20of%206%E2%80%90minute%20walk%20test%20reference%20values%20for%20spinal%20muscular%20atrophy&rft.jtitle=Muscle%20&%20nerve&rft.au=Goodwin,%20Ashley%20M.&rft.date=2020-03&rft.volume=61&rft.issue=3&rft.spage=375&rft.epage=382&rft.pages=375-382&rft.issn=0148-639X&rft.eissn=1097-4598&rft_id=info:doi/10.1002/mus.26794&rft_dat=%3Cproquest_pubme%3E2331430544%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2355148047&rft_id=info:pmid/31884700&rfr_iscdi=true |