Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus

•Curcumin maintains better cognitive and mood function in a model of Gulf War Illness.•Curcumin alleviates neuroinflammation in a model of Gulf War Illness.•Curcumin enhances hippocampal neurogenesis in a model of Gulf War Illness.•Curcumin normalizes mitochondrial function in a model of Gulf War Il...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2018-03, Vol.69, p.499-514
Hauptverfasser:	Kodali, M., Hattiangady, B., Shetty, G.A., Bates, A., Shuai, B., Shetty, A.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affect - drug effects Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cognition - drug effects Curcumin Curcumin - pharmacology Curcumin - therapeutic use DEET Disease Models, Animal Gulf War Illness Hippocampal neurogenesis Hippocampus - drug effects Hippocampus - metabolism Inflammation - drug therapy Inflammation - metabolism Inflammation - psychology Male Memory impairment Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mood dysfunction Neurogenesis - drug effects Neuroinflammation Oxidative stress Oxidative Stress - drug effects Permethrin Persian Gulf Syndrome - chemically induced Persian Gulf Syndrome - drug therapy Persian Gulf Syndrome - metabolism Persian Gulf Syndrome - psychology Rats Reactive oxygen species
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