Prognostic Values of LDH and CRP in Cervical Cancer
Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis. Based on pre-radiotherapy LDH and CRP med...
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| Veröffentlicht in: | OncoTargets and therapy 2020-02, Vol.13, p.1255-1263 |
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| creator | Wang, Han Wang, Meng-Sen Zhou, Yong-Heng Shi, Jian-Ping Wang, Wen-Jie |
| description | Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis.
Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group. Then, based on pre-/post-radiotherapy LDH and CRP ratios, we divided patients into four groups: high LDH and CRP ratio group, high LDH ratio group, high CRP ratio group, and low LDH and CRP ratio group. Kaplan-Meier (KM) curves were constructed to show overall survival (OS). A multivariate Cox regression model was employed to identify the independent risk factors.
High pre-radiotherapy LDH and CRP levels and increased pre-/post-radiotherapy LDH and CRP ratios were correlated with worst OS compared with the other three groups.
LDH and CRP were correlated with outcomes in patients with locally advanced cervical cancer. |
| doi_str_mv | 10.2147/OTT.S235027 |
| format | Article |
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Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group. Then, based on pre-/post-radiotherapy LDH and CRP ratios, we divided patients into four groups: high LDH and CRP ratio group, high LDH ratio group, high CRP ratio group, and low LDH and CRP ratio group. Kaplan-Meier (KM) curves were constructed to show overall survival (OS). A multivariate Cox regression model was employed to identify the independent risk factors.
High pre-radiotherapy LDH and CRP levels and increased pre-/post-radiotherapy LDH and CRP ratios were correlated with worst OS compared with the other three groups.
LDH and CRP were correlated with outcomes in patients with locally advanced cervical cancer.</description><identifier>ISSN: 1178-6930</identifier><identifier>EISSN: 1178-6930</identifier><identifier>DOI: 10.2147/OTT.S235027</identifier><identifier>PMID: 32103993</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>C-reactive protein ; Cancer metastasis ; Cervical cancer ; EDTA ; Enzymes ; Inflammation ; Original Research ; Prognosis ; Radiotherapy ; Risk factors ; Tumors</subject><ispartof>OncoTargets and therapy, 2020-02, Vol.13, p.1255-1263</ispartof><rights>2020 Wang et al.</rights><rights>COPYRIGHT 2020 Dove Medical Press Limited</rights><rights>2020 Wang et al. 2020 Wang et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-547ac51d1bf33bfdfa36386978822d3c834d9116f2dd3f6dbf8983912236ede63</citedby><orcidid>0000-0002-5214-1476</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023883/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023883/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32103993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Wang, Meng-Sen</creatorcontrib><creatorcontrib>Zhou, Yong-Heng</creatorcontrib><creatorcontrib>Shi, Jian-Ping</creatorcontrib><creatorcontrib>Wang, Wen-Jie</creatorcontrib><title>Prognostic Values of LDH and CRP in Cervical Cancer</title><title>OncoTargets and therapy</title><addtitle>Onco Targets Ther</addtitle><description>Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis.
Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group. Then, based on pre-/post-radiotherapy LDH and CRP ratios, we divided patients into four groups: high LDH and CRP ratio group, high LDH ratio group, high CRP ratio group, and low LDH and CRP ratio group. Kaplan-Meier (KM) curves were constructed to show overall survival (OS). A multivariate Cox regression model was employed to identify the independent risk factors.
High pre-radiotherapy LDH and CRP levels and increased pre-/post-radiotherapy LDH and CRP ratios were correlated with worst OS compared with the other three groups.
LDH and CRP were correlated with outcomes in patients with locally advanced cervical cancer.</description><subject>C-reactive protein</subject><subject>Cancer metastasis</subject><subject>Cervical cancer</subject><subject>EDTA</subject><subject>Enzymes</subject><subject>Inflammation</subject><subject>Original Research</subject><subject>Prognosis</subject><subject>Radiotherapy</subject><subject>Risk factors</subject><subject>Tumors</subject><issn>1178-6930</issn><issn>1178-6930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNptkd1LIzEUxYOsqOv65PsysCAL0m6S28lkXgQZd1UoKFp9DWk-2ixpUpOpsP_9RlqlBclDws3vnss9B6FTgoeUjJpfd5PJ8JFCjWmzh44IafiAtYC_bL0P0dec_2LMGKejA3QIlGBoWzhCcJ_iLMTcO1U9S78yuYq2Gl_dVDLoqnu4r1yoOpNenZK-6mRQJn1D-1b6bE429zF6-vN70t0MxnfXt93leKBqSvpBPWqkqokmUwswtdpKYMBZ23BOqQbFYaRbQpilWoNlemp5y6EllAIz2jA4Rhdr3eVqujBamdAn6cUyuYVM_0SUTuz-BDcXs_gqGkyBcygCPzcCKb6U1XqxcFkZ72UwcZVFGcQYQF23Bf2xRmfSG-GCjUVRveHikhEOuCnuFWr4CVWONgunYjDWlfpOw9lWw9xI389z9KvexZB3wfM1qFLMORn7sSbB4i1mUWIWm5gL_X3bmQ_2PVf4D6Nonrw</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Wang, Han</creator><creator>Wang, Meng-Sen</creator><creator>Zhou, Yong-Heng</creator><creator>Shi, Jian-Ping</creator><creator>Wang, Wen-Jie</creator><general>Dove Medical Press Limited</general><general>Dove</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5214-1476</orcidid></search><sort><creationdate>20200201</creationdate><title>Prognostic Values of LDH and CRP in Cervical Cancer</title><author>Wang, Han ; Wang, Meng-Sen ; Zhou, Yong-Heng ; Shi, Jian-Ping ; Wang, Wen-Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-547ac51d1bf33bfdfa36386978822d3c834d9116f2dd3f6dbf8983912236ede63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>C-reactive protein</topic><topic>Cancer metastasis</topic><topic>Cervical cancer</topic><topic>EDTA</topic><topic>Enzymes</topic><topic>Inflammation</topic><topic>Original Research</topic><topic>Prognosis</topic><topic>Radiotherapy</topic><topic>Risk factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Wang, Meng-Sen</creatorcontrib><creatorcontrib>Zhou, Yong-Heng</creatorcontrib><creatorcontrib>Shi, Jian-Ping</creatorcontrib><creatorcontrib>Wang, Wen-Jie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>OncoTargets and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Han</au><au>Wang, Meng-Sen</au><au>Zhou, Yong-Heng</au><au>Shi, Jian-Ping</au><au>Wang, Wen-Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Values of LDH and CRP in Cervical Cancer</atitle><jtitle>OncoTargets and therapy</jtitle><addtitle>Onco Targets Ther</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>13</volume><spage>1255</spage><epage>1263</epage><pages>1255-1263</pages><issn>1178-6930</issn><eissn>1178-6930</eissn><abstract>Cervical cancer is one of the deadliest tumors among women in China. C-reactive protein (CRP), an indicator of inflammation, and lactate dehydrogenase (LDH), an enzyme ubiquitously expressed in cells, both play important roles in tumor growth and metastasis.
Based on pre-radiotherapy LDH and CRP median levels, we divided patients into four groups: high LDH and CRP group, high LDH group, high CRP group, and low LDH and CRP group. Then, based on pre-/post-radiotherapy LDH and CRP ratios, we divided patients into four groups: high LDH and CRP ratio group, high LDH ratio group, high CRP ratio group, and low LDH and CRP ratio group. Kaplan-Meier (KM) curves were constructed to show overall survival (OS). A multivariate Cox regression model was employed to identify the independent risk factors.
High pre-radiotherapy LDH and CRP levels and increased pre-/post-radiotherapy LDH and CRP ratios were correlated with worst OS compared with the other three groups.
LDH and CRP were correlated with outcomes in patients with locally advanced cervical cancer.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>32103993</pmid><doi>10.2147/OTT.S235027</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5214-1476</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | C-reactive protein Cancer metastasis Cervical cancer EDTA Enzymes Inflammation Original Research Prognosis Radiotherapy Risk factors Tumors |
| title | Prognostic Values of LDH and CRP in Cervical Cancer |
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