Poly(vinyl alcohol)-based nanofibrous electrospun scaffolds for tissue engineering applications
Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread i...
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| Veröffentlicht in: | Polymers 2019-12, Vol.12 (1), p.1-33 |
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| description | Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.
This research was funded by the Portuguese Foundation for Science and Technology (FCT), FEDER funds by means of Portugal 2020 Competitive Factors Operational Program (POCI) and the Portuguese Government (OE) in the form of the grants POCI-01-0145-FEDER-028074 and UID/CTM/00264/2019. |
| doi_str_mv | 10.3390/polym12010007 |
| format | Article |
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This research was funded by the Portuguese Foundation for Science and Technology (FCT), FEDER funds by means of Portugal 2020 Competitive Factors Operational Program (POCI) and the Portuguese Government (OE) in the form of the grants POCI-01-0145-FEDER-028074 and UID/CTM/00264/2019.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym12010007</identifier><identifier>PMID: 31861485</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Alcohol ; Aqueous solutions ; Biocompatibility ; Biodegradability ; Cartilage ; Crosslinking ; Electrospinning ; Electrospun scaffolds ; Engenharia dos Materiais ; Engenharia e Tecnologia ; Flexibility ; Mechanical properties ; Mechanical stability ; Morphology ; Poly(vinyl alcohol) ; Polymers ; Polyvinyl alcohol ; Review ; Scaffolding ; Scaffolds ; Science & Technology ; Solvents ; Substrates ; Tensile strength ; Thermal stability ; Tissue engineering ; Transplantation</subject><ispartof>Polymers, 2019-12, Vol.12 (1), p.1-33</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-b858234fe9f8256f042433108ee7518f2bdd52560a7ca910cee5e29b9e54d7de3</citedby><cites>FETCH-LOGICAL-c506t-b858234fe9f8256f042433108ee7518f2bdd52560a7ca910cee5e29b9e54d7de3</cites><orcidid>0000-0002-4354-0256</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023576/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023576/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31861485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teixeira, Marta Albertina</creatorcontrib><creatorcontrib>Amorim, M. T. Pessoa de</creatorcontrib><creatorcontrib>Felgueiras, Helena Prado</creatorcontrib><title>Poly(vinyl alcohol)-based nanofibrous electrospun scaffolds for tissue engineering applications</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.
This research was funded by the Portuguese Foundation for Science and Technology (FCT), FEDER funds by means of Portugal 2020 Competitive Factors Operational Program (POCI) and the Portuguese Government (OE) in the form of the grants POCI-01-0145-FEDER-028074 and UID/CTM/00264/2019.</description><subject>Alcohol</subject><subject>Aqueous solutions</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Cartilage</subject><subject>Crosslinking</subject><subject>Electrospinning</subject><subject>Electrospun scaffolds</subject><subject>Engenharia dos Materiais</subject><subject>Engenharia e Tecnologia</subject><subject>Flexibility</subject><subject>Mechanical properties</subject><subject>Mechanical stability</subject><subject>Morphology</subject><subject>Poly(vinyl alcohol)</subject><subject>Polymers</subject><subject>Polyvinyl alcohol</subject><subject>Review</subject><subject>Scaffolding</subject><subject>Scaffolds</subject><subject>Science & Technology</subject><subject>Solvents</subject><subject>Substrates</subject><subject>Tensile strength</subject><subject>Thermal stability</subject><subject>Tissue engineering</subject><subject>Transplantation</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkcFrFDEUh4NYbFl79CoDXuph9CWZJDMXQYpVoWAPeg6ZzMs2JZuMyczC_vembFtaT3nwPj7yfj9C3lH4xPkAn-cUDjvKgAKAekXOGCjedlzC62fzKTkv5a4S0AkpqXpDTjntJe16cUb0TVVc7H08hMYEm25T-NiOpuDURBOT82NOa2kwoF1yKvMam2KNcylMpXEpN4svZcUG49ZHxOzjtjHzHLw1i0-xvCUnzoSC5w_vhvy5-vb78kd7_ev7z8uv160VIJd27EXPeOdwcD0T0kHHOs4p9IhK0N6xcZpEXYBR1gwULKJANowDim5SE_IN-XL0zuu4w8liXLIJes5-Z_JBJ-P1y030t3qb9loB40LJKrh4EOT0d8Wy6J0vFkMwEWsCmnE2KK5kTXVDPvyH3qU1x3qeZkIAEyCGe2F7pGzNrWR0T5-hoO_b0y_aq_z75xc80Y9dVaA5AtkaM-uMe18WUzTtGdOSS6X4PxzropY</recordid><startdate>20191218</startdate><enddate>20191218</enddate><creator>Teixeira, Marta Albertina</creator><creator>Amorim, M. 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Pessoa de ; Felgueiras, Helena Prado</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-b858234fe9f8256f042433108ee7518f2bdd52560a7ca910cee5e29b9e54d7de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Aqueous solutions</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Cartilage</topic><topic>Crosslinking</topic><topic>Electrospinning</topic><topic>Electrospun scaffolds</topic><topic>Engenharia dos Materiais</topic><topic>Engenharia e Tecnologia</topic><topic>Flexibility</topic><topic>Mechanical properties</topic><topic>Mechanical stability</topic><topic>Morphology</topic><topic>Poly(vinyl alcohol)</topic><topic>Polymers</topic><topic>Polyvinyl alcohol</topic><topic>Review</topic><topic>Scaffolding</topic><topic>Scaffolds</topic><topic>Science & Technology</topic><topic>Solvents</topic><topic>Substrates</topic><topic>Tensile strength</topic><topic>Thermal stability</topic><topic>Tissue engineering</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teixeira, Marta Albertina</creatorcontrib><creatorcontrib>Amorim, M. 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T. Pessoa de</au><au>Felgueiras, Helena Prado</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poly(vinyl alcohol)-based nanofibrous electrospun scaffolds for tissue engineering applications</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2019-12-18</date><risdate>2019</risdate><volume>12</volume><issue>1</issue><spage>1</spage><epage>33</epage><pages>1-33</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.
This research was funded by the Portuguese Foundation for Science and Technology (FCT), FEDER funds by means of Portugal 2020 Competitive Factors Operational Program (POCI) and the Portuguese Government (OE) in the form of the grants POCI-01-0145-FEDER-028074 and UID/CTM/00264/2019.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>31861485</pmid><doi>10.3390/polym12010007</doi><tpages>33</tpages><orcidid>https://orcid.org/0000-0002-4354-0256</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alcohol Aqueous solutions Biocompatibility Biodegradability Cartilage Crosslinking Electrospinning Electrospun scaffolds Engenharia dos Materiais Engenharia e Tecnologia Flexibility Mechanical properties Mechanical stability Morphology Poly(vinyl alcohol) Polymers Polyvinyl alcohol Review Scaffolding Scaffolds Science & Technology Solvents Substrates Tensile strength Thermal stability Tissue engineering Transplantation |
| title | Poly(vinyl alcohol)-based nanofibrous electrospun scaffolds for tissue engineering applications |
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