Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4 + T Cell Subsets during Long-Term Combination Antiretroviral Therapy

The HIV reservoir, which comprises diverse proviruses integrated into the genomes of infected, primarily CD4 T cells, is the main barrier to developing an effective HIV cure. Our understanding of the genetics and dynamics of proviruses persisting within distinct CD4 T cell subsets, however, remains...

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Veröffentlicht in:	Journal of virology 2020-02, Vol.94 (5)
Hauptverfasser:	Jones, Bradley R, Miller, Rachel L, Kinloch, Natalie N, Tsai, Olivia, Rigsby, Hawley, Sudderuddin, Hanwei, Shahid, Aniqa, Ganase, Bruce, Brumme, Chanson J, Harris, Marianne, Poon, Art F Y, Brockman, Mark A, Fromentin, Rémi, Chomont, Nicolas, Joy, Jeffrey B, Brumme, Zabrina L
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Diversity and Evolution
Online-Zugang:	Volltext
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