Leptin, Ghrelin, and Leptin/Ghrelin Ratio in Critically Ill Patients
The objective of this study was to evaluate leptin, ghrelin, and leptin/ghrelin ratio in critically ill patients and association of leptin/ghrelin ratio with outcomes. This is a sub-study of the PermiT trial (ISRCTN68144998). A subset of 72 patients who were expected to stay >14 days in the Inten...
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| Veröffentlicht in: | Nutrients 2019-12, Vol.12 (1), p.36 |
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| creator | Arabi, Yaseen M Jawdat, Dunia Al-Dorzi, Hasan M Tamim, Hani Tamimi, Waleed Bouchama, Abderrezak Sadat, Musharaf Afesh, Lara Abdullah, Mashan L Mashaqbeh, Walid Sakhija, Maram Al-Dawood, Abdulaziz |
| description | The objective of this study was to evaluate leptin, ghrelin, and leptin/ghrelin ratio in critically ill patients and association of leptin/ghrelin ratio with outcomes. This is a sub-study of the PermiT trial (ISRCTN68144998). A subset of 72 patients who were expected to stay >14 days in the Intensive care unit were enrolled. Blood samples were collected on days 1, 3, 5, 7, and 14. Samples were analyzed for leptin and active ghrelin in addition to other hormones. Baseline leptin/ghrelin ratio was calculated, and patients were stratified into low and high leptin/ghrelin ratio based on the median value of 236. There was a considerable variation in baseline leptin level: Median 5.22 ng/mL (Q1, Q3: 1.26, 17.60). Ghrelin level was generally low: 10.61 pg/mL (Q1, Q3: 8.62, 25.36). Patients with high leptin/ghrelin ratio compared to patients with low leptin/ghrelin ratio were older, had higher body mass index and more likely to be diabetic. There were no differences in leptin/ghrelin ratio between patients who received permissive underfeeding and standard feeding. Multivariable logistic regression analysis showed that age and body mass index were significant independent predictors of high leptin-ghrelin ratio. Leptin-ghrelin ratio was not associated with 90-day mortality or other outcomes. Age and body mass index are predictors of high leptin/ghrelin ratio. Leptin/ghrelin ratio is not affected by permissive underfeeding and is not associated with mortality. |
| doi_str_mv | 10.3390/nu12010036 |
| format | Article |
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This is a sub-study of the PermiT trial (ISRCTN68144998). A subset of 72 patients who were expected to stay >14 days in the Intensive care unit were enrolled. Blood samples were collected on days 1, 3, 5, 7, and 14. Samples were analyzed for leptin and active ghrelin in addition to other hormones. Baseline leptin/ghrelin ratio was calculated, and patients were stratified into low and high leptin/ghrelin ratio based on the median value of 236. There was a considerable variation in baseline leptin level: Median 5.22 ng/mL (Q1, Q3: 1.26, 17.60). Ghrelin level was generally low: 10.61 pg/mL (Q1, Q3: 8.62, 25.36). Patients with high leptin/ghrelin ratio compared to patients with low leptin/ghrelin ratio were older, had higher body mass index and more likely to be diabetic. There were no differences in leptin/ghrelin ratio between patients who received permissive underfeeding and standard feeding. Multivariable logistic regression analysis showed that age and body mass index were significant independent predictors of high leptin-ghrelin ratio. Leptin-ghrelin ratio was not associated with 90-day mortality or other outcomes. Age and body mass index are predictors of high leptin/ghrelin ratio. Leptin/ghrelin ratio is not affected by permissive underfeeding and is not associated with mortality.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12010036</identifier><identifier>PMID: 31877773</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Appetite ; Body mass ; Body mass index ; Body size ; Confidence intervals ; Cytokines ; Diabetes mellitus ; Ghrelin ; Homeostasis ; Hormones ; Hospitals ; Laboratories ; Leptin ; Mortality ; Nervous system ; Pathogenesis ; Polypeptides ; Proteins ; Regression analysis ; Renal replacement therapy ; Sepsis ; Ventilators</subject><ispartof>Nutrients, 2019-12, Vol.12 (1), p.36</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-802576ea11c6c0a4fa688e1c8fe0263cd19aac3c42c7be859f587f2b5a630053</citedby><cites>FETCH-LOGICAL-c406t-802576ea11c6c0a4fa688e1c8fe0263cd19aac3c42c7be859f587f2b5a630053</cites><orcidid>0000-0002-4628-1536 ; 0000-0001-5735-6241 ; 0000-0002-3772-8949 ; 0000-0002-4145-1890</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020071/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020071/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31877773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arabi, Yaseen M</creatorcontrib><creatorcontrib>Jawdat, Dunia</creatorcontrib><creatorcontrib>Al-Dorzi, Hasan M</creatorcontrib><creatorcontrib>Tamim, Hani</creatorcontrib><creatorcontrib>Tamimi, Waleed</creatorcontrib><creatorcontrib>Bouchama, Abderrezak</creatorcontrib><creatorcontrib>Sadat, Musharaf</creatorcontrib><creatorcontrib>Afesh, Lara</creatorcontrib><creatorcontrib>Abdullah, Mashan L</creatorcontrib><creatorcontrib>Mashaqbeh, Walid</creatorcontrib><creatorcontrib>Sakhija, Maram</creatorcontrib><creatorcontrib>Al-Dawood, Abdulaziz</creatorcontrib><title>Leptin, Ghrelin, and Leptin/Ghrelin Ratio in Critically Ill Patients</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The objective of this study was to evaluate leptin, ghrelin, and leptin/ghrelin ratio in critically ill patients and association of leptin/ghrelin ratio with outcomes. 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Multivariable logistic regression analysis showed that age and body mass index were significant independent predictors of high leptin-ghrelin ratio. Leptin-ghrelin ratio was not associated with 90-day mortality or other outcomes. Age and body mass index are predictors of high leptin/ghrelin ratio. 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This is a sub-study of the PermiT trial (ISRCTN68144998). A subset of 72 patients who were expected to stay >14 days in the Intensive care unit were enrolled. Blood samples were collected on days 1, 3, 5, 7, and 14. Samples were analyzed for leptin and active ghrelin in addition to other hormones. Baseline leptin/ghrelin ratio was calculated, and patients were stratified into low and high leptin/ghrelin ratio based on the median value of 236. There was a considerable variation in baseline leptin level: Median 5.22 ng/mL (Q1, Q3: 1.26, 17.60). Ghrelin level was generally low: 10.61 pg/mL (Q1, Q3: 8.62, 25.36). Patients with high leptin/ghrelin ratio compared to patients with low leptin/ghrelin ratio were older, had higher body mass index and more likely to be diabetic. There were no differences in leptin/ghrelin ratio between patients who received permissive underfeeding and standard feeding. Multivariable logistic regression analysis showed that age and body mass index were significant independent predictors of high leptin-ghrelin ratio. Leptin-ghrelin ratio was not associated with 90-day mortality or other outcomes. Age and body mass index are predictors of high leptin/ghrelin ratio. Leptin/ghrelin ratio is not affected by permissive underfeeding and is not associated with mortality.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31877773</pmid><doi>10.3390/nu12010036</doi><orcidid>https://orcid.org/0000-0002-4628-1536</orcidid><orcidid>https://orcid.org/0000-0001-5735-6241</orcidid><orcidid>https://orcid.org/0000-0002-3772-8949</orcidid><orcidid>https://orcid.org/0000-0002-4145-1890</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Appetite Body mass Body mass index Body size Confidence intervals Cytokines Diabetes mellitus Ghrelin Homeostasis Hormones Hospitals Laboratories Leptin Mortality Nervous system Pathogenesis Polypeptides Proteins Regression analysis Renal replacement therapy Sepsis Ventilators |
| title | Leptin, Ghrelin, and Leptin/Ghrelin Ratio in Critically Ill Patients |
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